Speedy A–Cdk2 binding mediates initial telomere–nuclear envelope attachment during meiotic prophase I independent of Cdk2 activation

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 114; no. 3; pp. 592 - 597
• Main Authors: Tu, Zhaowei, Bayazit, Mustafa Bilal, Liu, Hongbin, Zhang, Jingjing, Busayavalasa, Kiran, Risal, Sanjiv, Shao, Jingchen, Satyanarayana, Ande, Coppola, Vincenzo, Tessarollo, Lino, Singh, Meenakshi, Zheng, Chunwei, Han, Chunsheng, Chen, Zijiang, Kaldis, Philipp, Gustafsson, Jan-Åke, Liu, Kui
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 17.01.2017
• Subjects: Animals; arrest; Biochemistry and Molecular Biology; Biokemi och molekylärbiologi; Biological Sciences; Cdk2; Cell Cycle Proteins - deficiency; Cell Cycle Proteins - genetics; Cell Cycle Proteins - metabolism; cell-cycle regulator; Cells; Chemical Sciences; Chromosomes; Cyclin-Dependent Kinase 2 - chemistry; Cyclin-Dependent Kinase 2 - metabolism; Cyclin-dependent kinases; dynamics; Enzyme Activation; Female; germ cells; Kemi; localization; Male; mammalian meiosis; Medicin och hälsovetenskap; meiosis; Meiotic Prophase I - physiology; Mice; Mice, Inbred C57BL; Mice, Knockout; Nuclear Envelope - metabolism; oocytes; Oocytes - cytology; Oocytes - metabolism; proliferation; protein; Protein Interaction Domains and Motifs; Rodents; Science & Technology - Other Topics; Speedy A; Spermatocytes - cytology; Spermatocytes - metabolism; telomere; Telomere - metabolism; Speedy A; meiosis; germ cells; Cdk2; telomere

Telomere attachment to the nuclear envelope (NE) is a prerequisite for chromosome movement during meiotic prophase I that is required for pairing of homologous chromosomes, synapsis, and homologous recombination. Here we show that Speedy A, a noncanonical activator of cyclin-dependent kinases (Cdks)...