Immunometabolism at the interface between macrophages and pathogens

• Published in: Nature reviews. Immunology Vol. 19; no. 5; pp. 291 - 304
• Main Authors: Russell, David G., Huang, Lu, VanderVen, Brian C.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.05.2019; Nature Publishing Group
• Subjects: 631/250/2499; 631/250/2504/342/1726; 631/326/41/2533; 631/443/319; Animals; Bacterial diseases; Bacterial infections; Biomedical and Life Sciences; Biomedicine; Cell metabolism; Environmental effects; Heterogeneity; Host-Pathogen Interactions - immunology; Humans; Immune response; Immunity - immunology; Immunologic research; Immunology; Infection; Infections; Macrophages; Macrophages - immunology; Macrophages - metabolism; Metabolism; Metabolism - immunology; Microorganisms; Pathogenic microorganisms; Pathogens; Physiological aspects; Review Article; Technology

It is generally regarded that the progression of an infection within host macrophages is the consequence of a failed immune response. However, recent appreciation of macrophage heterogeneity, with respect to both development and metabolism, indicates that the reality is more complex. Different linea...