Synergistic stimulation of type I interferons during influenza virus coinfection promotes Streptococcus pneumoniae colonization in mice

• Published in: The Journal of clinical investigation Vol. 121; no. 9; pp. 3657 - 3665
• Main Authors: Nakamura, Shigeki, Davis, Kimberly M., Weiser, Jeffrey N.
• Format: Journal Article
• Language: English
• Published: United States American Society for Clinical Investigation 01.09.2011
• Subjects: Animals; Bacteria; Biomedical research; Cells, Cultured; Chemokine CCL2 - immunology; Chemokines; Diagnosis; Dosage and administration; Drug therapy; Female; Flow cytometry; Genetic aspects; Influenza; Interferon; Interferon Type I - immunology; Macrophages; Macrophages - cytology; Macrophages - immunology; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mortality; Neutrophils; Nod2 Signaling Adaptor Protein - genetics; Nod2 Signaling Adaptor Protein - metabolism; Organisms; Orthomyxoviridae - immunology; Orthomyxoviridae - pathogenicity; Orthomyxoviridae Infections - complications; Orthomyxoviridae Infections - immunology; Orthomyxoviridae Infections - microbiology; Orthomyxoviridae Infections - virology; Pandemics; Pattern recognition; Pneumococcal Infections - etiology; Pneumococcal Infections - immunology; Pneumococcal Infections - microbiology; Pneumococcal Infections - virology; Pneumonia; Pneumonia, Pneumococcal; Streptococcus infections; Streptococcus pneumoniae - immunology; Streptococcus pneumoniae - pathogenicity; Trachea - immunology; Trachea - microbiology; Trachea - virology; Viral infections; Japan

Pneumococcal infection of the respiratory tract is often secondary to recent influenza virus infection and accounts for much of the morbidity and mortality during seasonal and pandemic influenza. Here, we show that coinfection of the upper respiratory tract of mice with influenza virus and pneumococ...