Third-party fecal microbiota transplantation following allo-HCT reconstitutes microbiome diversity

• Published in: Blood advances Vol. 2; no. 7; pp. 745 - 753
• Main Authors: DeFilipp, Zachariah, Peled, Jonathan U., Li, Shuli, Mahabamunuge, Jasmin, Dagher, Zeina, Slingerland, Ann E., Del Rio, Candice, Valles, Betsy, Kempner, Maria E., Smith, Melissa, Brown, Jami, Dey, Bimalangshu R., El-Jawahri, Areej, McAfee, Steven L., Spitzer, Thomas R., Ballen, Karen K., Sung, Anthony D., Dalton, Tara E., Messina, Julia A., Dettmer, Katja, Liebisch, Gerhard, Oefner, Peter, Taur, Ying, Pamer, Eric G., Holler, Ernst, Mansour, Michael K., van den Brink, Marcel R.M., Hohmann, Elizabeth, Jenq, Robert R., Chen, Yi-Bin
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 10.04.2018; American Society of Hematology; Elsevier
• Subjects: Adult; Aged; Allografts; Bacteremia - etiology; Fecal Microbiota Transplantation - methods; Fecal Microbiota Transplantation - mortality; Female; Gastrointestinal Tract - pathology; Graft vs Host Disease - etiology; Graft vs Host Disease - pathology; Hematopoietic Stem Cell Transplantation - methods; Humans; Male; Microbiota - genetics; Middle Aged; Pilot Projects; Survival Analysis; Transplantation

We hypothesized that third-party fecal microbiota transplantation (FMT) may restore intestinal microbiome diversity after allogeneic hematopoietic cell transplantation (allo-HCT). In this open-label single-group pilot study, 18 subjects were enrolled before allo-HCT and planned to receive third-part...