Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human

• Published in: Nature (London) Vol. 483; no. 7389; pp. 350 - 354
• Main Authors: Ichimura, Atsuhiko, Hirasawa, Akira, Poulain-Godefroy, Odile, Bonnefond, Amélie, Hara, Takafumi, Yengo, Loïc, Kimura, Ikuo, Leloire, Audrey, Liu, Ning, Iida, Keiko, Choquet, Hélène, Besnard, Philippe, Lecoeur, Cécile, Vivequin, Sidonie, Ayukawa, Kumiko, Takeuchi, Masato, Ozawa, Kentaro, Tauber, Maithé, Maffeis, Claudio, Morandi, Anita, Buzzetti, Raffaella, Elliott, Paul, Pouta, Anneli, Jarvelin, Marjo-Riitta, Körner, Antje, Kiess, Wieland, Pigeyre, Marie, Caiazzo, Roberto, Van Hul, Wim, Van Gaal, Luc, Horber, Fritz, Balkau, Beverley, Lévy-Marchal, Claire, Rouskas, Konstantinos, Kouvatsi, Anastasia, Hebebrand, Johannes, Hinney, Anke, Scherag, Andre, Pattou, François, Meyre, David, Koshimizu, Taka-aki, Wolowczuk, Isabelle, Tsujimoto, Gozoh, Froguel, Philippe
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 15.03.2012; Nature Publishing Group
• Subjects: 631/208/2489/144; 631/443/319; 631/443/319/1642/393; Adipocytes - metabolism; Adipocytes - pathology; Adipogenesis; Adipose Tissue - metabolism; Adipose Tissue - pathology; Animals; Biological and medical sciences; Calcium Signaling; Causes of; Cell Differentiation; Diet, High-Fat; DNA Mutational Analysis; Energy Metabolism; Europe - ethnology; Exons - genetics; Fatty Liver - complications; Fatty Liver - genetics; Fundamental and applied biological sciences. Psychology; Gene Expression Regulation; Glucagon-Like Peptide 1 - metabolism; Glucose - metabolism; Glucose Intolerance - complications; Humanities and Social Sciences; Humans; Insulin - metabolism; Insulin Resistance; letter; Lipogenesis; Liver - metabolism; Macrophages - metabolism; Medical sciences; Metabolic diseases; Mice; multidisciplinary; Mutation - genetics; Obesity; Obesity - complications; Obesity - genetics; Obesity - metabolism; Obesity - pathology; Physiological aspects; Receptors, G-Protein-Coupled - deficiency; Receptors, G-Protein-Coupled - genetics; Receptors, G-Protein-Coupled - metabolism; Science; Science (multidisciplinary); Signal Transduction - genetics; Vertebrates: nervous system and sense organs; White People - genetics; Europe; France; Finland; Appetite; Human; Obesity; Pancreatic hormone; Digestive system; Rodentia; Nutrition disorder; Homeostasis; Lipids; Free fatty acid; Feeding; Vertebrata; Mammalia; Mouse; Animal; Fat; Unsaturated fatty acid; Nutrient; Nutritional status; Food; G protein; Biological receptor

Mice deficient in the lipid sensor GPR120 develop obesity, glucose intolerance and fatty liver when fed a high-fat diet, and a loss-of-function variant in the GPR120 gene strongly contributes to increased obesity in human. A signal for obesity The G-protein-coupled receptor GPR120 is a receptor for...