Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis

Alcoholic hepatitis (AH) is a life-threatening condition characterized by profound hepatocellular dysfunction for which targeted treatments are urgently needed. Identification of molecular drivers is hampered by the lack of suitable animal models. By performing RNA sequencing in livers from patients...

Full description

Saved in:
Bibliographic Details
Published inNature communications Vol. 10; no. 1; pp. 3126 - 19
Main Authors Argemi, Josepmaria, Latasa, Maria U., Atkinson, Stephen R., Blokhin, Ilya O., Massey, Veronica, Gue, Joel P., Cabezas, Joaquin, Lozano, Juan J., Van Booven, Derek, Bell, Aaron, Cao, Sheng, Vernetti, Lawrence A., Arab, Juan P., Ventura-Cots, Meritxell, Edmunds, Lia R., Fondevila, Constantino, Stärkel, Peter, Dubuquoy, Laurent, Louvet, Alexandre, Odena, Gemma, Gomez, Juan L., Aragon, Tomas, Altamirano, Jose, Caballeria, Juan, Jurczak, Michael J., Taylor, D. Lansing, Berasain, Carmen, Wahlestedt, Claes, Monga, Satdarshan P., Morgan, Marsha Y., Sancho-Bru, Pau, Mathurin, Philippe, Furuya, Shinji, Lackner, Carolin, Rusyn, Ivan, Shah, Vijay H., Thursz, Mark R., Mann, Jelena, Avila, Matias A., Bataller, Ramon
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 16.07.2019
Nature Publishing Group
Nature Portfolio
SeriesNature Communications
Subjects
13/1
13/109
13/51
13/89
14
38/15
38/91
45/61
631/114/2114
692/4020/4021/1607/1608
692/4020/4021/288/2032
Adult
Aged
Alcoholic beverages
Animal models
Animals
Biopsy
Chromatin Assembly and Disassembly
Chromatin remodeling
Deoxyribonucleic acid
Disease Progression
DNA
DNA Methylation
Epigenesis, Genetic
Epigenetics
Female
Gene expression
Gene Expression Profiling
Gene Expression Regulation
Gene polymorphism
Gene sequencing
Hepatitis
Hepatitis, Alcoholic - genetics
Hepatitis, Alcoholic - pathology
Hepatocyte nuclear factor 4
Hepatocyte Nuclear Factor 4 - genetics
Hepatocyte Nuclear Factor 4 - metabolism
Hepatocytes
Hepatocytes - pathology
Humanities and Social Sciences
Humans
Life Sciences
Liver
Liver - cytology
Liver - pathology
Liver diseases
Male
Middle Aged
multidisciplinary
Phenotypes
Polymorphism, Genetic
Ribonucleic acid
RNA
Science
Sequence Analysis, RNA
Transcription factors
Transcriptomes
Transforming Growth Factor beta1 - genetics
Transforming Growth Factor beta1 - metabolism
Transforming growth factor-b1
Transforming Growth Factor beta1
RNA
Humans
Liver
Middle Aged
Gene Expression Regulation
Chromatin Assembly and Disassembly
Genetic
Male
Gene Expression Profiling
Disease Progression
Hepatitis
DNA Methylation
Animals
Hepatocytes
Biopsy
Alcoholic
Adult
Female
Aged
Epigenesis
Hepatocyte Nuclear Factor 4
Sequence Analysis
Polymorphism
Online AccessGet full text

Cover

Abstract Alcoholic hepatitis (AH) is a life-threatening condition characterized by profound hepatocellular dysfunction for which targeted treatments are urgently needed. Identification of molecular drivers is hampered by the lack of suitable animal models. By performing RNA sequencing in livers from patients with different phenotypes of alcohol-related liver disease (ALD), we show that development of AH is characterized by defective activity of liver-enriched transcription factors (LETFs). TGF β 1 is a key upstream transcriptome regulator in AH and induces the use of HNF4 α P2 promoter in hepatocytes, which results in defective metabolic and synthetic functions. Gene polymorphisms in LETFs including HNF4 α are not associated with the development of AH. In contrast, epigenetic studies show that AH livers have profound changes in DNA methylation state and chromatin remodeling, affecting HNF4 α -dependent gene expression. We conclude that targeting TGF β 1 and epigenetic drivers that modulate HNF4 α -dependent gene expression could be beneficial to improve hepatocellular function in patients with AH. Alcoholic hepatitis, a common cause of liver failure, lacks effective treatment. Here, the authors show altered hepatic HNF4a isoform expression and hypermethylation of its target genes in patients. HNF4a dysregulation is improved in vitro by TGFb or PPARg modulation suggesting potential therapeutic avenues.
AbstractList Alcoholic hepatitis (AH) is a life-threatening condition characterized by profound hepatocellular dysfunction for which targeted treatments are urgently needed. Identification of molecular drivers is hampered by the lack of suitable animal models. By performing RNA sequencing in livers from patients with different phenotypes of alcohol-related liver disease (ALD), we show that development of AH is characterized by defective activity of liver-enriched transcription factors (LETFs). TGFβ1 is a key upstream transcriptome regulator in AH and induces the use of HNF4α P2 promoter in hepatocytes, which results in defective metabolic and synthetic functions. Gene polymorphisms in LETFs including HNF4α are not associated with the development of AH. In contrast, epigenetic studies show that AH livers have profound changes in DNA methylation state and chromatin remodeling, affecting HNF4α-dependent gene expression. We conclude that targeting TGFβ1 and epigenetic drivers that modulate HNF4α-dependent gene expression could be beneficial to improve hepatocellular function in patients with AH.
Alcoholic hepatitis (AH) is a life-threatening condition characterized by profound hepatocellular dysfunction for which targeted treatments are urgently needed. Identification of molecular drivers is hampered by the lack of suitable animal models. By performing RNA sequencing in livers from patients with different phenotypes of alcohol-related liver disease (ALD), we show that development of AH is characterized by defective activity of liver-enriched transcription factors (LETFs). TGFβ1 is a key upstream transcriptome regulator in AH and induces the use of HNF4α P2 promoter in hepatocytes, which results in defective metabolic and synthetic functions. Gene polymorphisms in LETFs including HNF4α are not associated with the development of AH. In contrast, epigenetic studies show that AH livers have profound changes in DNA methylation state and chromatin remodeling, affecting HNF4α-dependent gene expression. We conclude that targeting TGFβ1 and epigenetic drivers that modulate HNF4α-dependent gene expression could be beneficial to improve hepatocellular function in patients with AH.Alcoholic hepatitis (AH) is a life-threatening condition characterized by profound hepatocellular dysfunction for which targeted treatments are urgently needed. Identification of molecular drivers is hampered by the lack of suitable animal models. By performing RNA sequencing in livers from patients with different phenotypes of alcohol-related liver disease (ALD), we show that development of AH is characterized by defective activity of liver-enriched transcription factors (LETFs). TGFβ1 is a key upstream transcriptome regulator in AH and induces the use of HNF4α P2 promoter in hepatocytes, which results in defective metabolic and synthetic functions. Gene polymorphisms in LETFs including HNF4α are not associated with the development of AH. In contrast, epigenetic studies show that AH livers have profound changes in DNA methylation state and chromatin remodeling, affecting HNF4α-dependent gene expression. We conclude that targeting TGFβ1 and epigenetic drivers that modulate HNF4α-dependent gene expression could be beneficial to improve hepatocellular function in patients with AH.
Alcoholic hepatitis (AH) is a life-threatening condition characterized by profound hepatocellular dysfunction for which targeted treatments are urgently needed. Identification of molecular drivers is hampered by the lack of suitable animal models. By performing RNA sequencing in livers from patients with different phenotypes of alcohol-related liver disease (ALD), we show that development of AH is characterized by defective activity of liver-enriched transcription factors (LETFs). TGF β 1 is a key upstream transcriptome regulator in AH and induces the use of HNF4 α P2 promoter in hepatocytes, which results in defective metabolic and synthetic functions. Gene polymorphisms in LETFs including HNF4 α are not associated with the development of AH. In contrast, epigenetic studies show that AH livers have profound changes in DNA methylation state and chromatin remodeling, affecting HNF4 α -dependent gene expression. We conclude that targeting TGF β 1 and epigenetic drivers that modulate HNF4 α -dependent gene expression could be beneficial to improve hepatocellular function in patients with AH. Alcoholic hepatitis, a common cause of liver failure, lacks effective treatment. Here, the authors show altered hepatic HNF4a isoform expression and hypermethylation of its target genes in patients. HNF4a dysregulation is improved in vitro by TGFb or PPARg modulation suggesting potential therapeutic avenues.
Alcoholic hepatitis, a common cause of liver failure, lacks effective treatment. Here, the authors show altered hepatic HNF4a isoform expression and hypermethylation of its target genes in patients. HNF4a dysregulation is improved in vitro by TGFb or PPARg modulation suggesting potential therapeutic avenues.
Alcoholic hepatitis (AH) is a life-threatening condition characterized by profound hepatocellular dysfunction for which targeted treatments are urgently needed. Identification of molecular drivers is hampered by the lack of suitable animal models. By performing RNA sequencing in livers from patients with different phenotypes of alcohol-related liver disease (ALD), we show that development of AH is characterized by defective activity of liver-enriched transcription factors (LETFs). TGFβ1 is a key upstream transcriptome regulator in AH and induces the use of HNF4α P2 promoter in hepatocytes, which results in defective metabolic and synthetic functions. Gene polymorphisms in LETFs including HNF4α are not associated with the development of AH. In contrast, epigenetic studies show that AH livers have profound changes in DNA methylation state and chromatin remodeling, affecting HNF4α-dependent gene expression. We conclude that targeting TGFβ1 and epigenetic drivers that modulate HNF4α-dependent gene expression could be beneficial to improve hepatocellular function in patients with AH.Alcoholic hepatitis, a common cause of liver failure, lacks effective treatment. Here, the authors show altered hepatic HNF4a isoform expression and hypermethylation of its target genes in patients. HNF4a dysregulation is improved in vitro by TGFb or PPARg modulation suggesting potential therapeutic avenues.
Alcoholic hepatitis (AH) is a life-threatening condition characterized by profound hepatocellular dysfunction for which targeted treatments are urgently needed. Identification of molecular drivers is hampered by the lack of suitable animal models. By performing RNA sequencing in livers from patients with different phenotypes of alcohol-related liver disease (ALD), we show that development of AH is characterized by defective activity of liver-enriched transcription factors (LETFs). TGF β 1 is a key upstream transcriptome regulator in AH and induces the use of HNF4 α P2 promoter in hepatocytes, which results in defective metabolic and synthetic functions. Gene polymorphisms in LETFs including HNF4 α are not associated with the development of AH. In contrast, epigenetic studies show that AH livers have profound changes in DNA methylation state and chromatin remodeling, affecting HNF4 α -dependent gene expression. We conclude that targeting TGF β 1 and epigenetic drivers that modulate HNF4 α -dependent gene expression could be beneficial to improve hepatocellular function in patients with AH.
ArticleNumber 3126
Author Mathurin, Philippe
Sancho-Bru, Pau
Blokhin, Ilya O.
Dubuquoy, Laurent
Gomez, Juan L.
Arab, Juan P.
Shah, Vijay H.
Odena, Gemma
Altamirano, Jose
Massey, Veronica
Edmunds, Lia R.
Furuya, Shinji
Monga, Satdarshan P.
Wahlestedt, Claes
Rusyn, Ivan
Argemi, Josepmaria
Aragon, Tomas
Jurczak, Michael J.
Thursz, Mark R.
Lozano, Juan J.
Ventura-Cots, Meritxell
Caballeria, Juan
Morgan, Marsha Y.
Avila, Matias A.
Atkinson, Stephen R.
Gue, Joel P.
Louvet, Alexandre
Cabezas, Joaquin
Bell, Aaron
Latasa, Maria U.
Lackner, Carolin
Van Booven, Derek
Vernetti, Lawrence A.
Bataller, Ramon
Berasain, Carmen
Fondevila, Constantino
Cao, Sheng
Stärkel, Peter
Taylor, D. Lansing
Mann, Jelena
Author_xml – sequence: 1
  givenname: Josepmaria
  orcidid: 0000-0003-1696-7753
  surname: Argemi
  fullname: Argemi, Josepmaria
  organization: Division of Gastroenterology, Hepatology and Nutrition, Pittsburgh Liver Research Center, University of Pittsburgh Medical Center (UPMC), Liver Unit, Clínica Universidad de Navarra, University of Navarra
– sequence: 2
  givenname: Maria U.
  orcidid: 0000-0002-0878-1337
  surname: Latasa
  fullname: Latasa, Maria U.
  organization: Hepatology Program, Center for Applied Medical Research (CIMA), University of Navarra
– sequence: 3
  givenname: Stephen R.
  surname: Atkinson
  fullname: Atkinson, Stephen R.
  organization: Division of Digestive Diseases, Department of Surgery and Cancer, Imperial College London
– sequence: 4
  givenname: Ilya O.
  surname: Blokhin
  fullname: Blokhin, Ilya O.
  organization: Center for Therapeutic Innovation and Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine
– sequence: 5
  givenname: Veronica
  surname: Massey
  fullname: Massey, Veronica
  organization: Division of Gastroenterology and Hepatology, Departments of Medicine and Nutrition and Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill
– sequence: 6
  givenname: Joel P.
  surname: Gue
  fullname: Gue, Joel P.
  organization: Division of Gastroenterology, Hepatology and Nutrition, Pittsburgh Liver Research Center, University of Pittsburgh Medical Center (UPMC)
– sequence: 7
  givenname: Joaquin
  orcidid: 0000-0003-0012-484X
  surname: Cabezas
  fullname: Cabezas, Joaquin
  organization: Division of Gastroenterology and Hepatology, Departments of Medicine and Nutrition and Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Departament of Hepatology, Marqués de Valdecilla University Hospital
– sequence: 8
  givenname: Juan J.
  surname: Lozano
  fullname: Lozano, Juan J.
  organization: Centro de Investigacion Biomedica en Red, Enfermedades Hepáticas y Digestivas (CIBERehd), Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)
– sequence: 9
  givenname: Derek
  surname: Van Booven
  fullname: Van Booven, Derek
  organization: John P. Hussman Institute of Human Genomics. Miller School of Medicine, University of Miami
– sequence: 10
  givenname: Aaron
  orcidid: 0000-0001-6648-0834
  surname: Bell
  fullname: Bell, Aaron
  organization: Departments of Pathology and Medicine, Pittsburgh Liver Research Center, University of Pittsburgh School of Medicine
– sequence: 11
  givenname: Sheng
  surname: Cao
  fullname: Cao, Sheng
  organization: Division of Gastroenterology and Hepatology, Mayo Clinic
– sequence: 12
  givenname: Lawrence A.
  surname: Vernetti
  fullname: Vernetti, Lawrence A.
  organization: University of Pittsburgh Drug Discovery Institute, Department of Computational & Systems Biology, University of Pittsburgh
– sequence: 13
  givenname: Juan P.
  orcidid: 0000-0002-8561-396X
  surname: Arab
  fullname: Arab, Juan P.
  organization: Division of Gastroenterology and Hepatology, Mayo Clinic, Departamento de Gastroenterologia, Escuela de Medicina, Pontificia Universidad Catolica de Chile
– sequence: 14
  givenname: Meritxell
  orcidid: 0000-0001-9513-2855
  surname: Ventura-Cots
  fullname: Ventura-Cots, Meritxell
  organization: Division of Gastroenterology, Hepatology and Nutrition, Pittsburgh Liver Research Center, University of Pittsburgh Medical Center (UPMC)
– sequence: 15
  givenname: Lia R.
  surname: Edmunds
  fullname: Edmunds, Lia R.
  organization: Department of Medicine, Division of Endocrinology and Metabolism, Center for Metabolic and Mitochondrial Medicine, University of Pittsburgh
– sequence: 16
  givenname: Constantino
  surname: Fondevila
  fullname: Fondevila, Constantino
  organization: Liver Transplant Unit, Department of Surgery, Hospital Clinic, University of Barcelona
– sequence: 17
  givenname: Peter
  orcidid: 0000-0003-2938-4442
  surname: Stärkel
  fullname: Stärkel, Peter
  organization: Service d’Hépato-gastroentérologie, Cliniques Universitaires Saint-Luc and Laboratory of Hepatogastroenterology, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain
– sequence: 18
  givenname: Laurent
  orcidid: 0000-0003-3596-5497
  surname: Dubuquoy
  fullname: Dubuquoy, Laurent
  organization: Service des Maladies de l’appareil digestif, CHU Lille. Inserm LIRIC - UMR995, University of Lille
– sequence: 19
  givenname: Alexandre
  surname: Louvet
  fullname: Louvet, Alexandre
  organization: Service des Maladies de l’appareil digestif, CHU Lille. Inserm LIRIC - UMR995, University of Lille
– sequence: 20
  givenname: Gemma
  surname: Odena
  fullname: Odena, Gemma
  organization: Division of Gastroenterology and Hepatology, Departments of Medicine and Nutrition and Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill
– sequence: 21
  givenname: Juan L.
  surname: Gomez
  fullname: Gomez, Juan L.
  organization: Departments of Pathology and Medicine, Pittsburgh Liver Research Center, University of Pittsburgh School of Medicine
– sequence: 22
  givenname: Tomas
  surname: Aragon
  fullname: Aragon, Tomas
  organization: Department of Gene Therapy and Regulation, Center for Applied Medical Research, University of Navarra
– sequence: 23
  givenname: Jose
  surname: Altamirano
  fullname: Altamirano, Jose
  organization: Liver Unit, Department of Internal Medicine, Vall d’Hebron Institut de Recerca. Internal Medicine Department, Hospital Quiron Salud
– sequence: 24
  givenname: Juan
  surname: Caballeria
  fullname: Caballeria, Juan
  organization: Centro de Investigacion Biomedica en Red, Enfermedades Hepáticas y Digestivas (CIBERehd), Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)
– sequence: 25
  givenname: Michael J.
  orcidid: 0000-0002-6335-6915
  surname: Jurczak
  fullname: Jurczak, Michael J.
  organization: Department of Medicine, Division of Endocrinology and Metabolism, Center for Metabolic and Mitochondrial Medicine, University of Pittsburgh
– sequence: 26
  givenname: D. Lansing
  surname: Taylor
  fullname: Taylor, D. Lansing
  organization: University of Pittsburgh Drug Discovery Institute, Department of Computational & Systems Biology, University of Pittsburgh
– sequence: 27
  givenname: Carmen
  orcidid: 0000-0001-7075-2476
  surname: Berasain
  fullname: Berasain, Carmen
  organization: Hepatology Program, Center for Applied Medical Research (CIMA), University of Navarra, Centro de Investigacion Biomedica en Red, Enfermedades Hepáticas y Digestivas (CIBERehd)
– sequence: 28
  givenname: Claes
  orcidid: 0000-0003-4471-5916
  surname: Wahlestedt
  fullname: Wahlestedt, Claes
  organization: Center for Therapeutic Innovation and Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine
– sequence: 29
  givenname: Satdarshan P.
  orcidid: 0000-0002-8437-3378
  surname: Monga
  fullname: Monga, Satdarshan P.
  organization: Departments of Pathology and Medicine, Pittsburgh Liver Research Center, University of Pittsburgh School of Medicine
– sequence: 30
  givenname: Marsha Y.
  surname: Morgan
  fullname: Morgan, Marsha Y.
  organization: UCL Institute for Liver and Digestive Health, Division of Medicine, Royal Free Campus, University College London
– sequence: 31
  givenname: Pau
  orcidid: 0000-0001-5569-9259
  surname: Sancho-Bru
  fullname: Sancho-Bru, Pau
  organization: Centro de Investigacion Biomedica en Red, Enfermedades Hepáticas y Digestivas (CIBERehd), Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)
– sequence: 32
  givenname: Philippe
  surname: Mathurin
  fullname: Mathurin, Philippe
  organization: Service des Maladies de l’appareil digestif, CHU Lille. Inserm LIRIC - UMR995, University of Lille
– sequence: 33
  givenname: Shinji
  surname: Furuya
  fullname: Furuya, Shinji
  organization: Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University
– sequence: 34
  givenname: Carolin
  surname: Lackner
  fullname: Lackner, Carolin
  organization: Medical University of Graz, Institute of Pathology
– sequence: 35
  givenname: Ivan
  surname: Rusyn
  fullname: Rusyn, Ivan
  organization: Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University
– sequence: 36
  givenname: Vijay H.
  surname: Shah
  fullname: Shah, Vijay H.
  organization: Division of Gastroenterology and Hepatology, Mayo Clinic
– sequence: 37
  givenname: Mark R.
  surname: Thursz
  fullname: Thursz, Mark R.
  organization: Division of Digestive Diseases, Department of Surgery and Cancer, Imperial College London
– sequence: 38
  givenname: Jelena
  surname: Mann
  fullname: Mann, Jelena
  organization: Newcastle Fibrosis Research Group, Institute of Cellular Medicine, Faculty of Medical Sciences, Newcastle University
– sequence: 39
  givenname: Matias A.
  surname: Avila
  fullname: Avila, Matias A.
  organization: Hepatology Program, Center for Applied Medical Research (CIMA), University of Navarra, Centro de Investigacion Biomedica en Red, Enfermedades Hepáticas y Digestivas (CIBERehd)
– sequence: 40
  givenname: Ramon
  orcidid: 0000-0001-6570-3557
  surname: Bataller
  fullname: Bataller, Ramon
  email: bataller@pitt.edu
  organization: Division of Gastroenterology, Hepatology and Nutrition, Pittsburgh Liver Research Center, University of Pittsburgh Medical Center (UPMC), Division of Gastroenterology and Hepatology, Departments of Medicine and Nutrition and Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill
BackLink https://www.ncbi.nlm.nih.gov/pubmed/31311938$$D View this record in MEDLINE/PubMed
https://hal.univ-lille.fr/hal-03113100$$DView record in HAL
BookMark eNp9kkFv1DAQhSNUREvpH-CAInGBQ8BjO7FzQaoKZSut4AJny3Emu15542AnK_j3OE0L7R6aiyP7e8-emfcyO-l9j1n2GsgHIEx-jBx4JQoCdQFACC_Ys-yMEg4FCMpOHvyfZhcx7kj6WA2S8xfZKQMGUDN5lu0-Y4dmtAfMV9-uuXbDVhctDti32I_5BnvM8fcQMEbr-1zHXOdtSHjIfZdvcdCjN-jc5HTIO23dFDC3CXTGb72zZmHsaOOr7HmnXcSLu_U8-3n95cfVqlh__3pzdbkuTFXJsRC60ZJy0LVoeCUbKUQnCBem0YxBxytDOqBVSQWypm2pMQ2R0CIRLZOCd-w8u1l8W693agh2r8Mf5bVVtxs-bJQOozUOFekaAaSirYGS65rUCJJBUzcdB0pZm7w-LV7D1OyxNaknQbtHpo9PertVG39QVcVKJlgyeL8YbI9kq8u1mvdImgRLAzxAYt_dXRb8rwnjqPY2zs3VPfopKkrLmlWUlzKhb4_QnZ9Cn9qqqBAlMMkkfZKipRQESjFf--Zhjf9eeR-SBMgFMMHHGLBTxo5ppn4u2ToFRM2RVEskVYqkuo2kmsunR9J79ydFbBHFBPcbDP-f_YTqL9bU8Ok
CitedBy_id crossref_primary_10_3390_cancers13061265
crossref_primary_10_1089_dna_2022_0669
crossref_primary_10_1172_JCI157780
crossref_primary_10_1055_a_2349_7236
crossref_primary_10_1136_egastro_2023_100046
crossref_primary_10_3390_cells9051237
crossref_primary_10_1136_egastro_2024_100166
crossref_primary_10_1097_HEP_0000000000000373
crossref_primary_10_1055_s_0041_1725023
crossref_primary_10_1021_acsnano_4c02987
crossref_primary_10_3748_wjg_v29_i17_2551
crossref_primary_10_1016_j_jhep_2021_05_041
crossref_primary_10_3390_jox12040019
crossref_primary_10_1002_hep4_1763
crossref_primary_10_1111_acer_14234
crossref_primary_10_1016_j_jcmgh_2022_09_013
crossref_primary_10_1002_hep_32115
crossref_primary_10_1016_j_jhep_2020_12_005
crossref_primary_10_1515_almed_2021_0023
crossref_primary_10_3390_cells9102185
crossref_primary_10_1146_annurev_pathmechdis_031521_030435
crossref_primary_10_3390_cells11243983
crossref_primary_10_1097_HEP_0000000000000303
crossref_primary_10_12688_f1000research_20394_1
crossref_primary_10_1097_HEP_0000000000000024
crossref_primary_10_1002_hep4_1505
crossref_primary_10_1038_s44321_024_00130_1
crossref_primary_10_1016_j_intimp_2024_113162
crossref_primary_10_1016_j_molmet_2023_101804
crossref_primary_10_1097_HEP_0000000000000381
crossref_primary_10_1016_j_ajpath_2022_08_009
crossref_primary_10_1038_s41598_023_47238_x
crossref_primary_10_1136_gutjnl_2024_334094
crossref_primary_10_1016_j_jhep_2023_04_013
crossref_primary_10_1111_cas_15686
crossref_primary_10_1097_HC9_0000000000000510
crossref_primary_10_3390_cells8111419
crossref_primary_10_1016_j_ifacol_2023_01_032
crossref_primary_10_1016_j_livres_2022_01_003
crossref_primary_10_1038_s41467_021_27385_3
crossref_primary_10_1096_fj_202101506RRR
crossref_primary_10_1097_HEP_0000000000000354
crossref_primary_10_1016_j_jhep_2022_09_001
crossref_primary_10_1038_s41398_020_01163_z
crossref_primary_10_1016_j_jcmgh_2023_11_009
crossref_primary_10_1016_j_mce_2024_112407
crossref_primary_10_15698_mic2024_08_836
crossref_primary_10_1016_j_jhepr_2024_101118
crossref_primary_10_3390_ijms23052636
crossref_primary_10_1002_hep_31046
crossref_primary_10_1016_j_jhepr_2022_100466
crossref_primary_10_1155_2023_4399998
crossref_primary_10_15252_embr_202357020
crossref_primary_10_1097_HC9_0000000000000450
crossref_primary_10_1016_j_jhep_2022_03_025
crossref_primary_10_1038_s42003_024_06288_1
crossref_primary_10_1038_s41598_020_72172_7
crossref_primary_10_1172_JCI131919
crossref_primary_10_3389_fendo_2023_1226173
crossref_primary_10_1007_s12072_022_10473_x
crossref_primary_10_1136_bmj_2023_077090
crossref_primary_10_14309_ajg_0000000000002275
crossref_primary_10_1002_hep_32029
crossref_primary_10_1016_j_jhep_2021_08_011
crossref_primary_10_1055_a_2097_0660
crossref_primary_10_1136_gutjnl_2021_324295
crossref_primary_10_1172_JCI176345
crossref_primary_10_1136_gutjnl_2023_331741
crossref_primary_10_1097_HC9_0000000000000564
crossref_primary_10_1096_fj_202101398R
crossref_primary_10_1097_HC9_0000000000000284
crossref_primary_10_1002_hep4_1956
crossref_primary_10_1172_jci_insight_174127
crossref_primary_10_1016_j_jhepr_2023_100918
crossref_primary_10_1038_s42003_023_04571_1
crossref_primary_10_1002_hep4_1563
crossref_primary_10_1016_j_cld_2024_06_005
crossref_primary_10_1111_acer_14954
crossref_primary_10_2139_ssrn_4168546
crossref_primary_10_1016_j_jhepr_2025_101338
crossref_primary_10_1152_ajpcell_00281_2022
crossref_primary_10_1016_j_jcmgh_2020_01_013
crossref_primary_10_1016_j_celrep_2022_111775
crossref_primary_10_1194_jlr_RA119000446
crossref_primary_10_1016_j_ajpath_2021_02_008
crossref_primary_10_1097_HEP_0000000000000986
crossref_primary_10_1002_med_21881
crossref_primary_10_1515_almed_2021_0068
crossref_primary_10_1002_biof_1794
crossref_primary_10_3390_ijms24097791
crossref_primary_10_1038_s41401_022_00920_8
crossref_primary_10_1111_liv_15326
crossref_primary_10_1172_jci_insight_159775
crossref_primary_10_1053_j_gastro_2020_12_008
crossref_primary_10_3390_biom11020281
crossref_primary_10_3389_fendo_2023_1266527
crossref_primary_10_1055_a_1713_3796
crossref_primary_10_3390_metabo12121157
crossref_primary_10_1111_acer_14700
crossref_primary_10_1038_s42003_023_05055_y
crossref_primary_10_1016_j_jcmgh_2024_01_021
crossref_primary_10_1002_hep_32326
crossref_primary_10_1002_hep_32203
crossref_primary_10_1016_j_ajpath_2022_04_004
crossref_primary_10_1097_HEP_0000000000000675
crossref_primary_10_7554_eLife_76554
crossref_primary_10_1038_s42003_022_03319_7
crossref_primary_10_1016_j_bios_2022_114767
crossref_primary_10_1016_j_jcmgh_2023_12_009
crossref_primary_10_1073_pnas_1911870117
crossref_primary_10_1056_EVIDoa2400243
crossref_primary_10_1016_j_biopha_2023_115923
crossref_primary_10_1111_acer_14338
crossref_primary_10_1186_s12916_021_01917_6
crossref_primary_10_1016_j_phrs_2021_105846
crossref_primary_10_1016_j_lfs_2021_119328
crossref_primary_10_1056_NEJMra2207599
crossref_primary_10_1002_ctd2_18
crossref_primary_10_1186_s13036_024_00428_1
crossref_primary_10_1111_apt_18274
crossref_primary_10_3350_cmh_2022_0017
crossref_primary_10_3350_cmh_2024_0709
crossref_primary_10_7554_eLife_71310
crossref_primary_10_1111_liv_15701
crossref_primary_10_3390_biom14040404
crossref_primary_10_1016_j_cgh_2023_02_017
crossref_primary_10_1016_j_cmet_2023_11_010
crossref_primary_10_1042_CS20230522
crossref_primary_10_1038_s41586_025_08677_w
crossref_primary_10_1080_14656566_2024_2409941
crossref_primary_10_3390_cells13221893
Cites_doi 10.1093/nar/gkx1126
10.1016/j.alcohol.2012.05.005
10.1093/nar/gkm427
10.1186/s13742-015-0047-8
10.1093/bioinformatics/btr260
10.1016/S0168-8278(00)80122-1
10.1124/dmd.105.006759
10.1136/gutjnl-2014-308410
10.4161/15592294.2014.971608
10.1371/journal.pcbi.1004219
10.1007/s00018-015-1970-7
10.1038/ng.2354
10.1002/hep.27353
10.1053/j.gastro.2011.09.002
10.1038/355457a0
10.1038/nprot.2016.095
10.1038/nature13270
10.1002/hep.20701
10.1186/s12864-017-4371-5
10.1186/1756-8935-8-6
10.1128/MCB.17.4.1913
10.1038/35093050
10.1056/NEJMoa1105703
10.1016/j.jhep.2016.08.011
10.1371/journal.pone.0060335
10.1172/JCI73137
10.1128/MCB.16.4.1824
10.1038/gt.2010.41
10.1074/jbc.M105490200
10.1093/nar/gkh131
10.1038/ng.3417
10.1177/1087057103255988
10.1371/journal.pone.0025168
10.1016/j.jhep.2016.11.011
10.1002/hep4.1172
10.1101/gad.4.12b.2353
10.1074/jbc.M807497200
10.1007/s00394-015-1098-4
10.1016/S0168-8278(16)01634-2
10.1093/nar/gkr1291
10.1152/ajpgi.00094.2004
10.1128/MCB.00030-15
10.1186/1471-2105-15-280
10.1053/j.gastro.2014.01.018
10.1074/jbc.M207545200
10.1053/j.gastro.2017.09.022
10.1016/S0140-6736(14)61838-9
10.1093/nar/gkx1067
10.1038/srep35610
10.1093/nar/gkv007
10.1038/nprot.2015.123
10.1002/hep.29887
10.1016/S0140-6736(06)67924-5
10.1073/pnas.1518393112
10.1093/database/bav067
10.1016/S0014-5793(03)00174-1
10.1016/S0925-4773(01)00521-4
10.1007/s005340070034
10.1186/1471-2105-12-323
10.1128/MCB.21.4.1393-1403.2001
10.1016/j.jhep.2010.12.023
10.1073/pnas.1419161111
10.1038/nmeth0410-248
10.1002/hep.25614
10.1073/pnas.0909781107
10.1056/NEJMoa1412278
10.1093/bioinformatics/bti394
10.1038/ng.2653
10.1074/jbc.M405312200
10.1093/bioinformatics/btu049
10.1111/j.1530-0277.1989.tb00276.x
10.3892/ijo.2011.897
10.1073/pnas.1106799109
10.1016/j.compbiomed.2014.12.003
10.1101/gr.108803.110
10.1093/toxsci/kfy292
10.1002/0471141755.ph1430s66
ContentType Journal Article
Copyright The Author(s) 2019. corrected publication 2023
2019. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
The Author(s) 2019. corrected publication 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Attribution
The Author(s) 2019
Copyright_xml – notice: The Author(s) 2019. corrected publication 2023
– notice: 2019. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
– notice: The Author(s) 2019. corrected publication 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
– notice: Attribution
– notice: The Author(s) 2019
DBID C6C
AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
3V.
7QL
7QP
7QR
7SN
7SS
7ST
7T5
7T7
7TM
7TO
7X7
7XB
88E
8AO
8FD
8FE
8FG
8FH
8FI
8FJ
8FK
ABUWG
AEUYN
AFKRA
ARAPS
AZQEC
BBNVY
BENPR
BGLVJ
BHPHI
C1K
CCPQU
DWQXO
FR3
FYUFA
GHDGH
GNUQQ
H94
HCIFZ
K9.
LK8
M0S
M1P
M7P
P5Z
P62
P64
PHGZM
PHGZT
PIMPY
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQQKQ
PQUKI
PRINS
RC3
SOI
7X8
1XC
VOOES
5PM
DOA
DOI 10.1038/s41467-019-11004-3
DatabaseName Springer Nature OA Free Journals
CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
ProQuest Central (Corporate)
Bacteriology Abstracts (Microbiology B)
Calcium & Calcified Tissue Abstracts
Chemoreception Abstracts
Ecology Abstracts
Entomology Abstracts (Full archive)
Environment Abstracts
Immunology Abstracts
Industrial and Applied Microbiology Abstracts (Microbiology A)
Nucleic Acids Abstracts
Oncogenes and Growth Factors Abstracts
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
ProQuest Pharma Collection
Technology Research Database
ProQuest SciTech Collection
ProQuest Technology Collection
ProQuest Natural Science Collection
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest One Sustainability
ProQuest Central UK/Ireland
Advanced Technologies & Aerospace Collection
ProQuest Central Essentials
Biological Science Collection
ProQuest Central
Technology Collection
Natural Science Collection
Environmental Sciences and Pollution Management
ProQuest One
ProQuest Central Korea
Engineering Research Database
Proquest Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
AIDS and Cancer Research Abstracts
SciTech Premium Collection
ProQuest Health & Medical Complete (Alumni)
ProQuest Biological Science Collection
ProQuest Health & Medical Collection
PML(ProQuest Medical Library)
Biological Science Database
Advanced Technologies & Aerospace Database
ProQuest Advanced Technologies & Aerospace Collection
Biotechnology and BioEngineering Abstracts
ProQuest Central Premium
ProQuest One Academic (New)
Publicly Available Content Database
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
ProQuest One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Applied & Life Sciences
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
Genetics Abstracts
Environment Abstracts
MEDLINE - Academic
Hyper Article en Ligne (HAL)
Hyper Article en Ligne (HAL) (Open Access)
PubMed Central (Full Participant titles)
DOAJ Directory of Open Access Journals
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
Publicly Available Content Database
ProQuest Central Student
Oncogenes and Growth Factors Abstracts
ProQuest Advanced Technologies & Aerospace Collection
ProQuest Central Essentials
Nucleic Acids Abstracts
SciTech Premium Collection
ProQuest Central China
Environmental Sciences and Pollution Management
ProQuest One Applied & Life Sciences
ProQuest One Sustainability
Health Research Premium Collection
Natural Science Collection
Health & Medical Research Collection
Biological Science Collection
Chemoreception Abstracts
Industrial and Applied Microbiology Abstracts (Microbiology A)
ProQuest Central (New)
ProQuest Medical Library (Alumni)
Advanced Technologies & Aerospace Collection
ProQuest Biological Science Collection
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
ProQuest Technology Collection
Health Research Premium Collection (Alumni)
Biological Science Database
Ecology Abstracts
ProQuest Hospital Collection (Alumni)
Biotechnology and BioEngineering Abstracts
Entomology Abstracts
ProQuest Health & Medical Complete
ProQuest One Academic UKI Edition
Engineering Research Database
ProQuest One Academic
Calcium & Calcified Tissue Abstracts
ProQuest One Academic (New)
Technology Collection
Technology Research Database
ProQuest One Academic Middle East (New)
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest One Health & Nursing
ProQuest Natural Science Collection
ProQuest Pharma Collection
ProQuest Central
ProQuest Health & Medical Research Collection
Genetics Abstracts
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
Bacteriology Abstracts (Microbiology B)
AIDS and Cancer Research Abstracts
ProQuest SciTech Collection
Advanced Technologies & Aerospace Database
ProQuest Medical Library
Immunology Abstracts
Environment Abstracts
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList MEDLINE
MEDLINE - Academic


Publicly Available Content Database

Publicly Available Content Database
CrossRef
Database_xml – sequence: 1
  dbid: C6C
  name: Springer Nature OA Free Journals
  url: http://www.springeropen.com/
  sourceTypes: Publisher
– sequence: 2
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 3
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 4
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 5
  dbid: 8FG
  name: ProQuest Technology Collection
  url: https://search.proquest.com/technologycollection1
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
EISSN 2041-1723
EndPage 19
ExternalDocumentID oai_doaj_org_article_0fb71062dc154a909e1831b9bf41223d
PMC6635373
oai_HAL_hal_03113100v1
31311938
10_1038_s41467_019_11004_3
Genre Research Support, Non-U.S. Gov't
Journal Article
Research Support, N.I.H., Extramural
GrantInformation_xml – fundername: U.S. Department of Health & Human Services | NIH | National Institute on Alcohol Abuse and Alcoholism (NIAAA)
  grantid: U01AA021908; R01AA023781; UO1AA018663
  funderid: https://doi.org/10.13039/100000027
– fundername: RCUK | Medical Research Council (MRC)
  grantid: MK/K001949/1
  funderid: https://doi.org/10.13039/501100000265
– fundername: Hepacare Project (Fundacion La Caixa) Fond de la recherche scientifique médicale (FRSM T.0217.18) Miguel Servet (CPII16/00041) NIH T32 DK007052 “Una manera de hacer Europa” program, European Regional Development Fund (ERDF)
– fundername: DH | NIHR | Health Technology Assessment Programme (NIHR Health Technology Assessment Programme)
  grantid: 08-14-44
  funderid: https://doi.org/10.13039/501100000664
– fundername: Environmental Protection Agency (EPA)
  grantid: STAR 83573601
  funderid: https://doi.org/10.13039/501100001589
– fundername: Fonds De La Recherche Scientifique - FNRS (Belgian National Fund for Scientific Research)
  grantid: J.0146.17
  funderid: https://doi.org/10.13039/501100002661
– fundername: Ministry of Economy and Competitiveness | Instituto de Salud Carlos III (Institute of Health Carlos III)
  grantid: PI17/00673
  funderid: https://doi.org/10.13039/501100004587
– fundername: NCATS NIH HHS
  grantid: UH3 TR000503
– fundername: Medical Research Council
  grantid: MR/M003132/1
– fundername: Medical Research Council
  grantid: MR/R014019/1
– fundername: NIDDK NIH HHS
  grantid: P30 DK120531
– fundername: NIAAA NIH HHS
  grantid: R37 AA021171
– fundername: NIDDK NIH HHS
  grantid: T32 DK007052
– fundername: NIAAA NIH HHS
  grantid: U01 AA021908
– fundername: Medical Research Council
  grantid: MR/K001949/1
– fundername: NIDDK NIH HHS
  grantid: R01 DK101426
– fundername: NIDDK NIH HHS
  grantid: R01 DK062277
– fundername: ;
– fundername: ;
  grantid: PI17/00673
– fundername: ;
  grantid: 08-14-44
– fundername: ;
  grantid: MK/K001949/1
– fundername: ;
  grantid: U01AA021908; R01AA023781; UO1AA018663
– fundername: ;
  grantid: J.0146.17
– fundername: ;
  grantid: STAR 83573601
GroupedDBID ---
0R~
39C
3V.
53G
5VS
70F
7X7
88E
8AO
8FE
8FG
8FH
8FI
8FJ
AAHBH
AAJSJ
ABUWG
ACGFO
ACGFS
ACIWK
ACMJI
ACPRK
ACSMW
ADBBV
ADFRT
ADMLS
ADRAZ
AENEX
AEUYN
AFKRA
AFRAH
AHMBA
AJTQC
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AMTXH
AOIJS
ARAPS
ASPBG
AVWKF
AZFZN
BBNVY
BCNDV
BENPR
BGLVJ
BHPHI
BPHCQ
BVXVI
C6C
CCPQU
DIK
EBLON
EBS
EE.
EMOBN
F5P
FEDTE
FYUFA
GROUPED_DOAJ
HCIFZ
HMCUK
HVGLF
HYE
HZ~
KQ8
LK8
M1P
M48
M7P
M~E
NAO
O9-
OK1
P2P
P62
PIMPY
PQQKQ
PROAC
PSQYO
RNS
RNT
RNTTT
RPM
SNYQT
SV3
TSG
UKHRP
AASML
AAYXX
CITATION
PHGZM
PHGZT
CGR
CUY
CVF
ECM
EIF
NPM
PJZUB
PPXIY
PQGLB
7QL
7QP
7QR
7SN
7SS
7ST
7T5
7T7
7TM
7TO
7XB
8FD
8FK
AARCD
AZQEC
C1K
DWQXO
FR3
GNUQQ
H94
K9.
P64
PKEHL
PQEST
PQUKI
PRINS
RC3
SOI
7X8
1XC
VOOES
5PM
PUEGO
ID FETCH-LOGICAL-c668t-7aba8241a97b468b877f7047cba331f46c0f126527e3bdd2ccb081de07d3874f3
IEDL.DBID DOA
ISSN 2041-1723
IngestDate Wed Aug 27 01:20:32 EDT 2025
Thu Aug 21 14:12:02 EDT 2025
Thu May 22 06:34:40 EDT 2025
Fri Jul 11 00:21:35 EDT 2025
Wed Aug 13 11:33:34 EDT 2025
Wed Aug 13 09:28:56 EDT 2025
Mon Jul 21 06:03:00 EDT 2025
Thu Apr 24 23:02:29 EDT 2025
Tue Jul 01 04:08:40 EDT 2025
Fri Feb 21 02:40:14 EST 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 1
Keywords Transforming Growth Factor beta1
RNA
Humans
Liver
Middle Aged
Gene Expression Regulation
Chromatin Assembly and Disassembly
Genetic
Male
Gene Expression Profiling
Disease Progression
Hepatitis
DNA Methylation
Animals
Hepatocytes
Biopsy
Alcoholic
Adult
Female
Aged
Epigenesis
Hepatocyte Nuclear Factor 4
Sequence Analysis
Polymorphism
Language English
License Attribution: http://creativecommons.org/licenses/by
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c668t-7aba8241a97b468b877f7047cba331f46c0f126527e3bdd2ccb081de07d3874f3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
ORCID 0000-0001-7075-2476
0000-0003-4471-5916
0000-0001-5569-9259
0000-0002-8437-3378
0000-0001-6648-0834
0000-0001-9513-2855
0000-0002-6335-6915
0000-0002-8561-396X
0000-0001-6570-3557
0000-0003-2938-4442
0000-0002-0878-1337
0000-0003-1696-7753
0000-0003-0012-484X
0000-0003-3596-5497
0000-0003-3447-2025
0000-0002-5293-007X
0000-0002-9809-4388
OpenAccessLink https://doaj.org/article/0fb71062dc154a909e1831b9bf41223d
PMID 31311938
PQID 2258701571
PQPubID 546298
PageCount 19
ParticipantIDs doaj_primary_oai_doaj_org_article_0fb71062dc154a909e1831b9bf41223d
pubmedcentral_primary_oai_pubmedcentral_nih_gov_6635373
hal_primary_oai_HAL_hal_03113100v1
proquest_miscellaneous_2259362458
proquest_journals_2775138382
proquest_journals_2258701571
pubmed_primary_31311938
crossref_citationtrail_10_1038_s41467_019_11004_3
crossref_primary_10_1038_s41467_019_11004_3
springer_journals_10_1038_s41467_019_11004_3
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2019-07-16
PublicationDateYYYYMMDD 2019-07-16
PublicationDate_xml – month: 07
  year: 2019
  text: 2019-07-16
  day: 16
PublicationDecade 2010
PublicationPlace London
PublicationPlace_xml – name: London
– name: England
PublicationSeriesTitle Nature Communications
PublicationTitle Nature communications
PublicationTitleAbbrev Nat Commun
PublicationTitleAlternate Nat Commun
PublicationYear 2019
Publisher Nature Publishing Group UK
Nature Publishing Group
Nature Portfolio
Publisher_xml – name: Nature Publishing Group UK
– name: Nature Publishing Group
– name: Nature Portfolio
References Shen (CR29) 2012; 40
Aryee (CR60) 2014; 30
Torres-Padilla, Weiss (CR27) 2003; 539
Pan, Chen, Huang, Yao, Ma (CR45) 2013; 8
Ritchie (CR54) 2015; 43
Shukla, Lim (CR11) 2013; 35
Weng, Wu, Lee, Hsu, Cheng (CR9) 2015; 64
Buch (CR7) 2015; 47
Leon, McCambridge (CR1) 2006; 367
Kuo (CR19) 1992; 355
Vuong (CR18) 2015; 35
Fu (CR37) 2001; 276
Peters (CR61) 2015; 8
Malik, Karathanasis (CR30) 1996; 16
Cardenas (CR43) 2014; 9
Liberzon (CR56) 2011; 27
Spath, Weiss (CR21) 1997; 17
CR70
(CR79) 2013; 45
Ungefroren, Sebens, Groth, Gieseler, Fandrich (CR35) 2011; 38
Gao, Bataller (CR4) 2011; 141
Yan (CR64) 2014; 15
Torres-Padilla, Fougere-Deschatrette, Weiss (CR26) 2001; 109
Mellinger, Shedden, Winder, Tapper, Adams, Fontana, Volk, Blow, Lok (CR5) 2018; 68
Hines, Wheeler (CR12) 2004; 287
Li (CR39) 2011; 55
Mathurin (CR48) 2011; 365
Berasain, Avila (CR23) 2015; 72
Zhang (CR44) 2011; 6
Briancon (CR32) 2004; 279
Chellappa (CR34) 2012; 109
Kleiner (CR49) 2005; 41
Ernst, Bar-Joseph (CR55) 2006
Williams (CR2) 2014; 384
Fan, Meng, Laterra, Rosen (CR36) 2009; 284
Dobin (CR51) 2013
Nishikawa (CR24) 2015; 125
Avila (CR25) 2000; 33
Guzman-Lepe (CR47) 2018; 2
Inokuchi (CR33) 2010; 107
Case, Deaton (CR3) 2015; 112
Tammen (CR10) 2017; 56
Zhong (CR63) 2017; 18
Stickel, Moreno, Hampe, Morgan (CR6) 2017; 66
Wu (CR38) 2010; 17
Shen (CR58) 2014; 111
Pertea, Kim, Pertea, Leek, Salzberg (CR59) 2016; 11
Chang (CR75) 2015; 4
Apweiler (CR81) 2004; 32
Khan, Fornes, Stigliani, Gheorghe, Castro-Mondragon, van der Lee, Bessy, Chèneby, Kulkarni, Tan, Baranasic, Arenillas, Sandelin, Vandepoele, Lenhard, Ballester, Wasserman, Parcy, Mathelier (CR62) 2017; 46
Aninat (CR65) 2006; 34
Lackner (CR50) 2017; 66
Kono (CR71) 2000; 7
Ho Sui, Fulton, Arenillas, Kwon, Wasserman (CR57) 2007; 35
Medvedeva (CR46) 2015; 2015
Sancho-Bru (CR15) 2012; 55
de Leeuw, Mooij, Heskes, Posthuma (CR80) 2015; 11
Hayhurst, Lee, Lambert, Ward, Gonzalez (CR22) 2001; 21
Yoon (CR67) 2001; 413
Satishchandran (CR40) 2018; 154
Dubois-Pot-Schneider (CR31) 2014; 60
Nanji, Mendenhall, French (CR72) 1989; 13
Adzhubei (CR78) 2010; 7
Dubuquoy (CR17) 2015; 64
Howie, Fuchsberger, Stephens, Marchini, Abecasis (CR76) 2012; 44
Torres-Padilla, Sladek, Weiss (CR28) 2002; 277
CR69
Atkinson, Morgan, Thursz (CR73) 2016; 64
Thursz, Forrest, Ryder (CR74) 2015; 373
Thursz (CR13) 2015; 372
Sladek, Zhong, Lai, Darnell (CR20) 1990; 4
Li, Dewey (CR52) 2011; 12
Di (CR66) 2003; 8
Madiraju (CR68) 2014; 510
Vaser, Adusumalli, Leng, Sikic, Ng (CR77) 2016; 11
Odena (CR16) 2016; 6
Culhane, Thioulouse, Perriere, Higgins (CR53) 2005; 21
Altamirano (CR14) 2014; 146
Chou (CR41) 2018; 46
Zahs (CR8) 2012; 46
Matsumura (CR42) 2011; 21
S Buch (11004_CR7) 2015; 47
GP Hayhurst (11004_CR22) 2001; 21
ME Ritchie (11004_CR54) 2015; 43
S Fan (11004_CR36) 2009; 284
J Altamirano (11004_CR14) 2014; 146
A Dobin (11004_CR51) 2013
CC Chang (11004_CR75) 2015; 4
R Vaser (11004_CR77) 2016; 11
ME Torres-Padilla (11004_CR26) 2001; 109
N Briancon (11004_CR32) 2004; 279
CH Chou (11004_CR41) 2018; 46
R Williams (11004_CR2) 2014; 384
MJ Aryee (11004_CR60) 2014; 30
P Mathurin (11004_CR48) 2011; 365
S Inokuchi (11004_CR33) 2010; 107
S Shen (11004_CR58) 2014; 111
C Berasain (11004_CR23) 2015; 72
B Gao (11004_CR4) 2011; 141
FM Sladek (11004_CR20) 1990; 4
R Apweiler (11004_CR81) 2004; 32
11004_CR69
P Sancho-Bru (11004_CR15) 2012; 55
MA Avila (11004_CR25) 2000; 33
H Ungefroren (11004_CR35) 2011; 38
JC Yoon (11004_CR67) 2001; 413
IA Adzhubei (11004_CR78) 2010; 7
X Pan (11004_CR45) 2013; 8
MR Thursz (11004_CR13) 2015; 372
GF Spath (11004_CR21) 1997; 17
SJ Ho Sui (11004_CR57) 2007; 35
AA Nanji (11004_CR72) 1989; 13
H Cardenas (11004_CR43) 2014; 9
ME Torres-Padilla (11004_CR27) 2003; 539
Jessica L. Mellinger (11004_CR5) 2018; 68
Aziz Khan (11004_CR62) 2017; 46
N Matsumura (11004_CR42) 2011; 21
Consortium, G.T. (11004_CR79) 2013; 45
ZY Li (11004_CR39) 2011; 55
CJ Kuo (11004_CR19) 1992; 355
LM Vuong (11004_CR18) 2015; 35
A Zahs (11004_CR8) 2012; 46
J Ernst (11004_CR55) 2006
B Howie (11004_CR76) 2012; 44
IN Hines (11004_CR12) 2004; 287
S Shen (11004_CR29) 2012; 40
AC Culhane (11004_CR53) 2005; 21
DA Leon (11004_CR1) 2006; 367
AK Madiraju (11004_CR68) 2014; 510
SWMA Atkinson (11004_CR73) 2016; 64
L Dubuquoy (11004_CR17) 2015; 64
H Dubois-Pot-Schneider (11004_CR31) 2014; 60
F Stickel (11004_CR6) 2017; 66
G Odena (11004_CR16) 2016; 6
JT Weng (11004_CR9) 2015; 64
Q Zhang (11004_CR44) 2011; 6
M Pertea (11004_CR59) 2016; 11
J Guzman-Lepe (11004_CR47) 2018; 2
SD Shukla (11004_CR11) 2013; 35
H Yan (11004_CR64) 2014; 15
C Lackner (11004_CR50) 2017; 66
CA de Leeuw (11004_CR80) 2015; 11
B Li (11004_CR52) 2011; 12
L Di (11004_CR66) 2003; 8
SA Tammen (11004_CR10) 2017; 56
ME Torres-Padilla (11004_CR28) 2002; 277
A Liberzon (11004_CR56) 2011; 27
J Zhong (11004_CR63) 2017; 18
A Case (11004_CR3) 2015; 112
TJ Peters (11004_CR61) 2015; 8
YA Medvedeva (11004_CR46) 2015; 2015
C Aninat (11004_CR65) 2006; 34
11004_CR70
A Satishchandran (11004_CR40) 2018; 154
S Malik (11004_CR30) 1996; 16
DE Kleiner (11004_CR49) 2005; 41
M Fu (11004_CR37) 2001; 276
K Chellappa (11004_CR34) 2012; 109
CW Wu (11004_CR38) 2010; 17
H Kono (11004_CR71) 2000; 7
T Nishikawa (11004_CR24) 2015; 125
MR Thursz (11004_CR74) 2015; 373
36765087 - Nat Commun. 2023 Feb 10;14(1):757. doi: 10.1038/s41467-023-36548-3.
References_xml – volume: 46
  start-page: D260
  issue: D1
  year: 2017
  end-page: D266
  ident: CR62
  article-title: JASPAR 2018: update of the open-access database of transcription factor binding profiles and its web framework
  publication-title: Nucleic Acids Research
  doi: 10.1093/nar/gkx1126
– ident: CR70
– volume: 46
  start-page: 783
  year: 2012
  end-page: 787
  ident: CR8
  article-title: Alcohol and epigenetic changes: summary of the 2011 Alcohol and Immunology Research Interest Group (AIRIG) meeting
  publication-title: Alcohol
  doi: 10.1016/j.alcohol.2012.05.005
– volume: 35
  start-page: W245
  year: 2007
  end-page: W252
  ident: CR57
  article-title: oPOSSUM: integrated tools for analysis of regulatory motif over-representation
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkm427
– volume: 4
  year: 2015
  ident: CR75
  article-title: Second-generation PLINK: rising to the challenge of larger and richer datasets
  publication-title: Gigascience
  doi: 10.1186/s13742-015-0047-8
– volume: 27
  start-page: 1739
  year: 2011
  end-page: 1740
  ident: CR56
  article-title: Molecular signatures database (MSigDB) 3.0
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btr260
– volume: 33
  start-page: 907
  year: 2000
  end-page: 914
  ident: CR25
  article-title: Reduced mRNA abundance of the main enzymes involved in methionine metabolism in human liver cirrhosis and hepatocellular carcinoma
  publication-title: J. Hepatol.
  doi: 10.1016/S0168-8278(00)80122-1
– volume: 34
  start-page: 75
  year: 2006
  end-page: 83
  ident: CR65
  article-title: Expression of cytochromes P450, conjugating enzymes and nuclear receptors in human hepatoma HepaRG cells
  publication-title: Drug Metab. Dispos.
  doi: 10.1124/dmd.105.006759
– volume: 64
  start-page: 1949
  year: 2015
  end-page: 1960
  ident: CR17
  article-title: Progenitor cell expansion and impaired hepatocyte regeneration in explanted livers from alcoholic hepatitis
  publication-title: Gut
  doi: 10.1136/gutjnl-2014-308410
– volume: 9
  start-page: 1461
  year: 2014
  end-page: 1472
  ident: CR43
  article-title: TGF-beta induces global changes in DNA methylation during the epithelial-to-mesenchymal transition in ovarian cancer cells
  publication-title: Epigenetics
  doi: 10.4161/15592294.2014.971608
– volume: 11
  start-page: e1004219
  year: 2015
  ident: CR80
  article-title: MAGMA: generalized gene-set analysis of GWAS data
  publication-title: PLoS Comput Biol.
  doi: 10.1371/journal.pcbi.1004219
– volume: 72
  start-page: 3831
  year: 2015
  end-page: 3851
  ident: CR23
  article-title: Regulation of hepatocyte identity and quiescence
  publication-title: Cell Mol. Life Sci.
  doi: 10.1007/s00018-015-1970-7
– volume: 44
  start-page: 955
  year: 2012
  end-page: 959
  ident: CR76
  article-title: Fast and accurate genotype imputation in genome-wide association studies through pre-phasing
  publication-title: Nat. Genet
  doi: 10.1038/ng.2354
– volume: 60
  start-page: 2077
  year: 2014
  end-page: 2090
  ident: CR31
  article-title: Inflammatory cytokines promote the retrodifferentiation of tumor-derived hepatocyte-like cells to progenitor cells
  publication-title: Hepatology
  doi: 10.1002/hep.27353
– volume: 141
  start-page: 1572
  year: 2011
  end-page: 1585
  ident: CR4
  article-title: Alcoholic liver disease: pathogenesis and new therapeutic targets
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2011.09.002
– volume: 355
  start-page: 457
  year: 1992
  end-page: 461
  ident: CR19
  article-title: A transcriptional hierarchy involved in mammalian cell-type specification
  publication-title: Nature
  doi: 10.1038/355457a0
– volume: 11
  start-page: 1650
  year: 2016
  end-page: 1667
  ident: CR59
  article-title: Transcript-level expression analysis of RNA-seq experiments with HISAT, StringTie and Ballgown
  publication-title: Nat. Protoc.
  doi: 10.1038/nprot.2016.095
– volume: 510
  start-page: 542
  year: 2014
  end-page: 546
  ident: CR68
  article-title: Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase
  publication-title: Nature
  doi: 10.1038/nature13270
– volume: 41
  start-page: 1313
  year: 2005
  end-page: 1321
  ident: CR49
  article-title: Design and validation of a histological scoring system for nonalcoholic fatty liver disease
  publication-title: Hepatology
  doi: 10.1002/hep.20701
– volume: 18
  year: 2017
  ident: CR63
  article-title: Purification of nanogram-range immunoprecipitated DNA in ChIP-seq application
  publication-title: BMC Genom.
  doi: 10.1186/s12864-017-4371-5
– volume: 8
  start-page: 6
  year: 2015
  ident: CR61
  article-title: De novo identification of differentially methylated regions in the human genome
  publication-title: Epigenetics Chromatin
  doi: 10.1186/1756-8935-8-6
– volume: 35
  start-page: 47
  year: 2013
  end-page: 55
  ident: CR11
  article-title: Epigenetic effects of ethanol on the liver and gastrointestinal system
  publication-title: Alcohol Res.
– volume: 17
  start-page: 1913
  year: 1997
  end-page: 1922
  ident: CR21
  article-title: Hepatocyte nuclear factor 4 expression overcomes repression of the hepatic phenotype in dedifferentiated hepatoma cells
  publication-title: Mol. Cell Biol.
  doi: 10.1128/MCB.17.4.1913
– volume: 413
  start-page: 131
  year: 2001
  end-page: 138
  ident: CR67
  article-title: Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1
  publication-title: Nature
  doi: 10.1038/35093050
– volume: 365
  start-page: 1790
  year: 2011
  end-page: 1800
  ident: CR48
  article-title: Early liver transplantation for severe alcoholic hepatitis
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa1105703
– volume: 66
  start-page: 195
  year: 2017
  end-page: 211
  ident: CR6
  article-title: The genetics of alcohol dependence and alcohol-related liver disease
  publication-title: J. Hepatol.
  doi: 10.1016/j.jhep.2016.08.011
– volume: 8
  start-page: e60335
  year: 2013
  ident: CR45
  article-title: Transforming growth factor beta1 induces the expression of collagen type I by DNA methylation in cardiac fibroblasts
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0060335
– volume: 125
  start-page: 1533
  year: 2015
  end-page: 1544
  ident: CR24
  article-title: Resetting the transcription factor network reverses terminal chronic hepatic failure
  publication-title: J. Clin. Invest.
  doi: 10.1172/JCI73137
– volume: 16
  start-page: 1824
  year: 1996
  end-page: 1831
  ident: CR30
  article-title: TFIIB-directed transcriptional activation by the orphan nuclear receptor hepatocyte nuclear factor 4
  publication-title: Mol. Cell Biol.
  doi: 10.1128/MCB.16.4.1824
– volume: 17
  start-page: 790
  year: 2010
  end-page: 798
  ident: CR38
  article-title: PPARgamma is essential for protection against nonalcoholic steatohepatitis
  publication-title: Gene Ther.
  doi: 10.1038/gt.2010.41
– volume: 276
  start-page: 45888
  year: 2001
  end-page: 45894
  ident: CR37
  article-title: Peroxisome proliferator-activated receptor gamma inhibits transforming growth factor beta-induced connective tissue growth factor expression in human aortic smooth muscle cells by interfering with Smad3
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M105490200
– volume: 32
  start-page: D115
  year: 2004
  end-page: D119
  ident: CR81
  article-title: UniProt: the Universal Protein knowledgebase
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkh131
– volume: 47
  start-page: 1443
  year: 2015
  end-page: 1448
  ident: CR7
  article-title: A genome-wide association study confirms PNPLA3 and identifies TM6SF2 and MBOAT7 as risk loci for alcohol-related cirrhosis
  publication-title: Nat. Genet.
  doi: 10.1038/ng.3417
– volume: 8
  start-page: 453
  year: 2003
  end-page: 462
  ident: CR66
  article-title: Optimization of a higher throughput microsomal stability screening assay for profiling drug discovery candidates
  publication-title: J. Biomol. Screen
  doi: 10.1177/1087057103255988
– volume: 6
  start-page: e25168
  year: 2011
  ident: CR44
  article-title: TGF-beta regulates DNA methyltransferase expression in prostate cancer, correlates with aggressive capabilities, and predicts disease recurrence
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0025168
– volume: 66
  start-page: 610
  year: 2017
  end-page: 618
  ident: CR50
  article-title: Histological parameters and alcohol abstinence determine long-term prognosis in patients with alcoholic liver disease
  publication-title: J. Hepatol.
  doi: 10.1016/j.jhep.2016.11.011
– volume: 2
  start-page: 582
  year: 2018
  end-page: 594
  ident: CR47
  article-title: Liver-enriched transcription factor expression relates to chronic hepatic failure in humans
  publication-title: Hepatol. Commun.
  doi: 10.1002/hep4.1172
– start-page: 15
  year: 2013
  end-page: 21
  ident: CR51
  article-title: STAR: ultrafast universal RNA-seq aligner
  publication-title: Bioinformatics
– volume: 4
  start-page: 2353
  year: 1990
  end-page: 2365
  ident: CR20
  article-title: Liver-enriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily
  publication-title: Genes Dev.
  doi: 10.1101/gad.4.12b.2353
– volume: 284
  start-page: 7561
  year: 2009
  end-page: 7577
  ident: CR36
  article-title: Role of Src signal transduction pathways in scatter factor-mediated cellular protection
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M807497200
– start-page: 191
  year: 2006
  ident: CR55
  article-title: STEM: a tool for the analysis of short time series gene expression data
  publication-title: BMC Bioinformatics
– volume: 56
  start-page: 535
  year: 2017
  end-page: 544
  ident: CR10
  article-title: Hepatic DNA hydroxymethylation is site-specifically altered by chronic alcohol consumption and aging
  publication-title: Eur. J. Nutr.
  doi: 10.1007/s00394-015-1098-4
– volume: 64
  start-page: 1
  year: 2016
  ident: CR73
  article-title: Genome-wide association study identifies PNPLA3 and SLC38A4 as risk loci for alcoholic hepatitis
  publication-title: J. Hepatol.
  doi: 10.1016/S0168-8278(16)01634-2
– volume: 40
  start-page: e61
  year: 2012
  ident: CR29
  article-title: MATS: a Bayesian framework for flexible detection of differential alternative splicing from RNA-Seq data
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkr1291
– volume: 287
  start-page: G310
  year: 2004
  end-page: G314
  ident: CR12
  article-title: Recent advances in alcoholic liver disease III. Role of the innate immune response in alcoholic hepatitis
  publication-title: Am. J. Physiol. Gastrointest. Liver Physiol.
  doi: 10.1152/ajpgi.00094.2004
– volume: 35
  start-page: 3471
  year: 2015
  end-page: 3490
  ident: CR18
  article-title: Differential effects of hepatocyte nuclear factor 4Alpha isoforms on tumor growth and T-cell factor 4/AP-1 interactions in human colorectal cancer cells
  publication-title: Mol. Cell Biol.
  doi: 10.1128/MCB.00030-15
– volume: 15
  year: 2014
  ident: CR64
  article-title: HiChIP: a high-throughput pipeline for integrative analysis of ChIP-Seq data
  publication-title: BMC Bioinf.
  doi: 10.1186/1471-2105-15-280
– volume: 146
  start-page: 1231
  year: 2014
  end-page: 1239
  ident: CR14
  article-title: A histologic scoring system for prognosis of patients with alcoholic hepatitis
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2014.01.018
– volume: 277
  start-page: 44677
  year: 2002
  end-page: 44687
  ident: CR28
  article-title: Developmentally regulated N-terminal variants of the nuclear receptor hepatocyte nuclear factor 4alpha mediate multiple interactions through coactivator and corepressor-histone deacetylase complexes
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M207545200
– volume: 154
  start-page: 238
  year: 2018
  end-page: 252
  ident: CR40
  article-title: MicroRNA 122, regulated by GRLH2, protects livers of mice and patients from ethanol-induced liver disease
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2017.09.022
– volume: 384
  start-page: 1953
  year: 2014
  end-page: 1997
  ident: CR2
  article-title: Addressing liver disease in the UK: a blueprint for attaining excellence in health care and reducing premature mortality from lifestyle issues of excess consumption of alcohol, obesity, and viral hepatitis
  publication-title: Lancet
  doi: 10.1016/S0140-6736(14)61838-9
– volume: 46
  start-page: D296
  year: 2018
  end-page: D302
  ident: CR41
  article-title: miRTarBase update 2018: a resource for experimentally validated microRNA-target interactions
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkx1067
– volume: 6
  year: 2016
  ident: CR16
  article-title: LPS-TLR4 pathway mediates ductular cell expansion in alcoholic hepatitis
  publication-title: Sci. Rep.
  doi: 10.1038/srep35610
– volume: 43
  start-page: e47
  year: 2015
  ident: CR54
  article-title: limma powers differential expression analyses for RNA-sequencing and microarray studies
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkv007
– volume: 11
  start-page: 1
  year: 2016
  end-page: 9
  ident: CR77
  article-title: SIFT missense predictions for genomes
  publication-title: Nat. Protoc.
  doi: 10.1038/nprot.2015.123
– volume: 68
  start-page: 872
  issue: 3
  year: 2018
  end-page: 882
  ident: CR5
  article-title: The high burden of alcoholic cirrhosis in privately insured persons in the United States
  publication-title: Hepatology
  doi: 10.1002/hep.29887
– volume: 367
  start-page: 52
  year: 2006
  end-page: 56
  ident: CR1
  article-title: Liver cirrhosis mortality rates in Britain from 1950 to 2002: an analysis of routine data
  publication-title: Lancet
  doi: 10.1016/S0140-6736(06)67924-5
– volume: 112
  start-page: 15078
  year: 2015
  end-page: 15083
  ident: CR3
  article-title: Rising morbidity and mortality in midlife among white non-Hispanic Americans in the 21st century
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1518393112
– ident: CR69
– volume: 2015
  start-page: bav067
  year: 2015
  ident: CR46
  article-title: EpiFactors: a comprehensive database of human epigenetic factors and complexes
  publication-title: Database
  doi: 10.1093/database/bav067
– volume: 539
  start-page: 19
  year: 2003
  end-page: 23
  ident: CR27
  article-title: Effects of interactions of hepatocyte nuclear factor 4alpha isoforms with coactivators and corepressors are promoter-specific
  publication-title: FEBS Lett.
  doi: 10.1016/S0014-5793(03)00174-1
– volume: 109
  start-page: 183
  year: 2001
  end-page: 193
  ident: CR26
  article-title: Expression of HNF4alpha isoforms in mouse liver development is regulated by sequential promoter usage and constitutive 3’ end splicing
  publication-title: Mech. Dev.
  doi: 10.1016/S0925-4773(01)00521-4
– volume: 7
  start-page: 395
  year: 2000
  end-page: 400
  ident: CR71
  article-title: Development of an intragastric enteral model in the mouse: studies of alcohol-induced liver disease using knockout technology
  publication-title: J. Hepatobiliary Pancreat. Surg.
  doi: 10.1007/s005340070034
– volume: 12
  year: 2011
  ident: CR52
  article-title: RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome
  publication-title: BMC Bioinf.
  doi: 10.1186/1471-2105-12-323
– volume: 21
  start-page: 1393
  year: 2001
  end-page: 1403
  ident: CR22
  article-title: Hepatocyte nuclear factor 4alpha (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis
  publication-title: Mol. Cell Biol.
  doi: 10.1128/MCB.21.4.1393-1403.2001
– volume: 55
  start-page: 602
  year: 2011
  end-page: 611
  ident: CR39
  article-title: Positive regulation of hepatic miR-122 expression by HNF4alpha
  publication-title: J. Hepatol.
  doi: 10.1016/j.jhep.2010.12.023
– volume: 111
  start-page: E5593
  year: 2014
  end-page: E5601
  ident: CR58
  article-title: rMATS: robust and flexible detection of differential alternative splicing from replicate RNA-Seq data
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1419161111
– volume: 373
  start-page: 282
  year: 2015
  end-page: 283
  ident: CR74
  article-title: Prednisolone or pentoxifylline for alcoholic hepatitis
  publication-title: N. Engl. J. Med.
– volume: 7
  start-page: 248
  year: 2010
  end-page: 249
  ident: CR78
  article-title: A method and server for predicting damaging missense mutations
  publication-title: Nat. Methods
  doi: 10.1038/nmeth0410-248
– volume: 55
  start-page: 1931
  year: 2012
  end-page: 1941
  ident: CR15
  article-title: Liver progenitor cell markers correlate with liver damage and predict short-term mortality in patients with alcoholic hepatitis
  publication-title: Hepatology
  doi: 10.1002/hep.25614
– volume: 107
  start-page: 844
  year: 2010
  end-page: 849
  ident: CR33
  article-title: Disruption of TAK1 in hepatocytes causes hepatic injury, inflammation, fibrosis, and carcinogenesis
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.0909781107
– volume: 372
  start-page: 1619
  year: 2015
  end-page: 1628
  ident: CR13
  article-title: Prednisolone or pentoxifylline for alcoholic hepatitis
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa1412278
– volume: 21
  start-page: 2789
  year: 2005
  end-page: 2790
  ident: CR53
  article-title: MADE4: an R package for multivariate analysis of gene expression data
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/bti394
– volume: 45
  start-page: 580
  year: 2013
  end-page: 585
  ident: CR79
  article-title: The Genotype-Tissue Expression (GTEx) project
  publication-title: Nat. Genet
  doi: 10.1038/ng.2653
– volume: 279
  start-page: 33398
  year: 2004
  end-page: 33408
  ident: CR32
  article-title: Expression of the alpha7 isoform of hepatocyte nuclear factor (HNF) 4 is activated by HNF6/OC-2 and HNF1 and repressed by HNF4alpha1 in the liver
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M405312200
– volume: 30
  start-page: 1363
  year: 2014
  end-page: 1369
  ident: CR60
  article-title: Minfi: a flexible and comprehensive Bioconductor package for the analysis of Infinium DNA methylation microarrays
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btu049
– volume: 13
  start-page: 15
  year: 1989
  end-page: 19
  ident: CR72
  article-title: Beef fat prevents alcoholic liver disease in the rat
  publication-title: Alcohol Clin. Exp. Res.
  doi: 10.1111/j.1530-0277.1989.tb00276.x
– volume: 38
  start-page: 797
  year: 2011
  end-page: 805
  ident: CR35
  article-title: Differential roles of Src in transforming growth factor-ss regulation of growth arrest, epithelial-to-mesenchymal transition and cell migration in pancreatic ductal adenocarcinoma cells
  publication-title: Int J. Oncol.
  doi: 10.3892/ijo.2011.897
– volume: 109
  start-page: 2302
  year: 2012
  end-page: 2307
  ident: CR34
  article-title: Src tyrosine kinase phosphorylation of nuclear receptor HNF4alpha correlates with isoform-specific loss of HNF4alpha in human colon cancer
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1106799109
– volume: 64
  start-page: 299
  year: 2015
  end-page: 306
  ident: CR9
  article-title: Integrative epigenetic profiling analysis identifies DNA methylation changes associated with chronic alcohol consumption
  publication-title: Comput. Biol. Med.
  doi: 10.1016/j.compbiomed.2014.12.003
– volume: 21
  start-page: 74
  year: 2011
  end-page: 82
  ident: CR42
  article-title: Epigenetic suppression of the TGF-beta pathway revealed by transcriptome profiling in ovarian cancer
  publication-title: Genome Res.
  doi: 10.1101/gr.108803.110
– volume: 365
  start-page: 1790
  year: 2011
  ident: 11004_CR48
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa1105703
– volume: 12
  year: 2011
  ident: 11004_CR52
  publication-title: BMC Bioinf.
  doi: 10.1186/1471-2105-12-323
– start-page: 191
  volume-title: BMC Bioinformatics
  year: 2006
  ident: 11004_CR55
– volume: 45
  start-page: 580
  year: 2013
  ident: 11004_CR79
  publication-title: Nat. Genet
  doi: 10.1038/ng.2653
– volume: 109
  start-page: 2302
  year: 2012
  ident: 11004_CR34
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1106799109
– volume: 40
  start-page: e61
  year: 2012
  ident: 11004_CR29
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkr1291
– volume: 6
  start-page: e25168
  year: 2011
  ident: 11004_CR44
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0025168
– volume: 47
  start-page: 1443
  year: 2015
  ident: 11004_CR7
  publication-title: Nat. Genet.
  doi: 10.1038/ng.3417
– volume: 8
  start-page: e60335
  year: 2013
  ident: 11004_CR45
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0060335
– volume: 2015
  start-page: bav067
  year: 2015
  ident: 11004_CR46
  publication-title: Database
  doi: 10.1093/database/bav067
– volume: 56
  start-page: 535
  year: 2017
  ident: 11004_CR10
  publication-title: Eur. J. Nutr.
  doi: 10.1007/s00394-015-1098-4
– start-page: 15
  volume-title: Bioinformatics
  year: 2013
  ident: 11004_CR51
– volume: 2
  start-page: 582
  year: 2018
  ident: 11004_CR47
  publication-title: Hepatol. Commun.
  doi: 10.1002/hep4.1172
– volume: 7
  start-page: 395
  year: 2000
  ident: 11004_CR71
  publication-title: J. Hepatobiliary Pancreat. Surg.
  doi: 10.1007/s005340070034
– volume: 141
  start-page: 1572
  year: 2011
  ident: 11004_CR4
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2011.09.002
– volume: 107
  start-page: 844
  year: 2010
  ident: 11004_CR33
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.0909781107
– volume: 32
  start-page: D115
  year: 2004
  ident: 11004_CR81
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkh131
– volume: 373
  start-page: 282
  year: 2015
  ident: 11004_CR74
  publication-title: N. Engl. J. Med.
– volume: 55
  start-page: 1931
  year: 2012
  ident: 11004_CR15
  publication-title: Hepatology
  doi: 10.1002/hep.25614
– volume: 154
  start-page: 238
  year: 2018
  ident: 11004_CR40
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2017.09.022
– ident: 11004_CR69
  doi: 10.1093/toxsci/kfy292
– ident: 11004_CR70
  doi: 10.1002/0471141755.ph1430s66
– volume: 18
  year: 2017
  ident: 11004_CR63
  publication-title: BMC Genom.
  doi: 10.1186/s12864-017-4371-5
– volume: 16
  start-page: 1824
  year: 1996
  ident: 11004_CR30
  publication-title: Mol. Cell Biol.
  doi: 10.1128/MCB.16.4.1824
– volume: 510
  start-page: 542
  year: 2014
  ident: 11004_CR68
  publication-title: Nature
  doi: 10.1038/nature13270
– volume: 13
  start-page: 15
  year: 1989
  ident: 11004_CR72
  publication-title: Alcohol Clin. Exp. Res.
  doi: 10.1111/j.1530-0277.1989.tb00276.x
– volume: 21
  start-page: 1393
  year: 2001
  ident: 11004_CR22
  publication-title: Mol. Cell Biol.
  doi: 10.1128/MCB.21.4.1393-1403.2001
– volume: 64
  start-page: 1
  year: 2016
  ident: 11004_CR73
  publication-title: J. Hepatol.
  doi: 10.1016/S0168-8278(16)01634-2
– volume: 539
  start-page: 19
  year: 2003
  ident: 11004_CR27
  publication-title: FEBS Lett.
  doi: 10.1016/S0014-5793(03)00174-1
– volume: 43
  start-page: e47
  year: 2015
  ident: 11004_CR54
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkv007
– volume: 66
  start-page: 195
  year: 2017
  ident: 11004_CR6
  publication-title: J. Hepatol.
  doi: 10.1016/j.jhep.2016.08.011
– volume: 384
  start-page: 1953
  year: 2014
  ident: 11004_CR2
  publication-title: Lancet
  doi: 10.1016/S0140-6736(14)61838-9
– volume: 68
  start-page: 872
  issue: 3
  year: 2018
  ident: 11004_CR5
  publication-title: Hepatology
  doi: 10.1002/hep.29887
– volume: 7
  start-page: 248
  year: 2010
  ident: 11004_CR78
  publication-title: Nat. Methods
  doi: 10.1038/nmeth0410-248
– volume: 46
  start-page: 783
  year: 2012
  ident: 11004_CR8
  publication-title: Alcohol
  doi: 10.1016/j.alcohol.2012.05.005
– volume: 277
  start-page: 44677
  year: 2002
  ident: 11004_CR28
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M207545200
– volume: 367
  start-page: 52
  year: 2006
  ident: 11004_CR1
  publication-title: Lancet
  doi: 10.1016/S0140-6736(06)67924-5
– volume: 112
  start-page: 15078
  year: 2015
  ident: 11004_CR3
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1518393112
– volume: 4
  year: 2015
  ident: 11004_CR75
  publication-title: Gigascience
  doi: 10.1186/s13742-015-0047-8
– volume: 8
  start-page: 6
  year: 2015
  ident: 11004_CR61
  publication-title: Epigenetics Chromatin
  doi: 10.1186/1756-8935-8-6
– volume: 55
  start-page: 602
  year: 2011
  ident: 11004_CR39
  publication-title: J. Hepatol.
  doi: 10.1016/j.jhep.2010.12.023
– volume: 64
  start-page: 299
  year: 2015
  ident: 11004_CR9
  publication-title: Comput. Biol. Med.
  doi: 10.1016/j.compbiomed.2014.12.003
– volume: 60
  start-page: 2077
  year: 2014
  ident: 11004_CR31
  publication-title: Hepatology
  doi: 10.1002/hep.27353
– volume: 30
  start-page: 1363
  year: 2014
  ident: 11004_CR60
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btu049
– volume: 66
  start-page: 610
  year: 2017
  ident: 11004_CR50
  publication-title: J. Hepatol.
  doi: 10.1016/j.jhep.2016.11.011
– volume: 72
  start-page: 3831
  year: 2015
  ident: 11004_CR23
  publication-title: Cell Mol. Life Sci.
  doi: 10.1007/s00018-015-1970-7
– volume: 21
  start-page: 74
  year: 2011
  ident: 11004_CR42
  publication-title: Genome Res.
  doi: 10.1101/gr.108803.110
– volume: 9
  start-page: 1461
  year: 2014
  ident: 11004_CR43
  publication-title: Epigenetics
  doi: 10.4161/15592294.2014.971608
– volume: 355
  start-page: 457
  year: 1992
  ident: 11004_CR19
  publication-title: Nature
  doi: 10.1038/355457a0
– volume: 109
  start-page: 183
  year: 2001
  ident: 11004_CR26
  publication-title: Mech. Dev.
  doi: 10.1016/S0925-4773(01)00521-4
– volume: 6
  year: 2016
  ident: 11004_CR16
  publication-title: Sci. Rep.
  doi: 10.1038/srep35610
– volume: 17
  start-page: 1913
  year: 1997
  ident: 11004_CR21
  publication-title: Mol. Cell Biol.
  doi: 10.1128/MCB.17.4.1913
– volume: 46
  start-page: D260
  issue: D1
  year: 2017
  ident: 11004_CR62
  publication-title: Nucleic Acids Research
  doi: 10.1093/nar/gkx1126
– volume: 41
  start-page: 1313
  year: 2005
  ident: 11004_CR49
  publication-title: Hepatology
  doi: 10.1002/hep.20701
– volume: 372
  start-page: 1619
  year: 2015
  ident: 11004_CR13
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa1412278
– volume: 35
  start-page: W245
  year: 2007
  ident: 11004_CR57
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkm427
– volume: 8
  start-page: 453
  year: 2003
  ident: 11004_CR66
  publication-title: J. Biomol. Screen
  doi: 10.1177/1087057103255988
– volume: 4
  start-page: 2353
  year: 1990
  ident: 11004_CR20
  publication-title: Genes Dev.
  doi: 10.1101/gad.4.12b.2353
– volume: 276
  start-page: 45888
  year: 2001
  ident: 11004_CR37
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M105490200
– volume: 284
  start-page: 7561
  year: 2009
  ident: 11004_CR36
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M807497200
– volume: 11
  start-page: 1
  year: 2016
  ident: 11004_CR77
  publication-title: Nat. Protoc.
  doi: 10.1038/nprot.2015.123
– volume: 287
  start-page: G310
  year: 2004
  ident: 11004_CR12
  publication-title: Am. J. Physiol. Gastrointest. Liver Physiol.
  doi: 10.1152/ajpgi.00094.2004
– volume: 279
  start-page: 33398
  year: 2004
  ident: 11004_CR32
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M405312200
– volume: 21
  start-page: 2789
  year: 2005
  ident: 11004_CR53
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/bti394
– volume: 35
  start-page: 3471
  year: 2015
  ident: 11004_CR18
  publication-title: Mol. Cell Biol.
  doi: 10.1128/MCB.00030-15
– volume: 125
  start-page: 1533
  year: 2015
  ident: 11004_CR24
  publication-title: J. Clin. Invest.
  doi: 10.1172/JCI73137
– volume: 11
  start-page: e1004219
  year: 2015
  ident: 11004_CR80
  publication-title: PLoS Comput Biol.
  doi: 10.1371/journal.pcbi.1004219
– volume: 64
  start-page: 1949
  year: 2015
  ident: 11004_CR17
  publication-title: Gut
  doi: 10.1136/gutjnl-2014-308410
– volume: 46
  start-page: D296
  year: 2018
  ident: 11004_CR41
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkx1067
– volume: 15
  year: 2014
  ident: 11004_CR64
  publication-title: BMC Bioinf.
  doi: 10.1186/1471-2105-15-280
– volume: 146
  start-page: 1231
  year: 2014
  ident: 11004_CR14
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2014.01.018
– volume: 38
  start-page: 797
  year: 2011
  ident: 11004_CR35
  publication-title: Int J. Oncol.
  doi: 10.3892/ijo.2011.897
– volume: 111
  start-page: E5593
  year: 2014
  ident: 11004_CR58
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1419161111
– volume: 33
  start-page: 907
  year: 2000
  ident: 11004_CR25
  publication-title: J. Hepatol.
  doi: 10.1016/S0168-8278(00)80122-1
– volume: 27
  start-page: 1739
  year: 2011
  ident: 11004_CR56
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btr260
– volume: 34
  start-page: 75
  year: 2006
  ident: 11004_CR65
  publication-title: Drug Metab. Dispos.
  doi: 10.1124/dmd.105.006759
– volume: 44
  start-page: 955
  year: 2012
  ident: 11004_CR76
  publication-title: Nat. Genet
  doi: 10.1038/ng.2354
– volume: 11
  start-page: 1650
  year: 2016
  ident: 11004_CR59
  publication-title: Nat. Protoc.
  doi: 10.1038/nprot.2016.095
– volume: 35
  start-page: 47
  year: 2013
  ident: 11004_CR11
  publication-title: Alcohol Res.
– volume: 17
  start-page: 790
  year: 2010
  ident: 11004_CR38
  publication-title: Gene Ther.
  doi: 10.1038/gt.2010.41
– volume: 413
  start-page: 131
  year: 2001
  ident: 11004_CR67
  publication-title: Nature
  doi: 10.1038/35093050
– reference: 36765087 - Nat Commun. 2023 Feb 10;14(1):757. doi: 10.1038/s41467-023-36548-3.
SSID ssj0000391844
Score 2.6100173
Snippet Alcoholic hepatitis (AH) is a life-threatening condition characterized by profound hepatocellular dysfunction for which targeted treatments are urgently...
Alcoholic hepatitis, a common cause of liver failure, lacks effective treatment. Here, the authors show altered hepatic HNF4a isoform expression and...
SourceID doaj
pubmedcentral
hal
proquest
pubmed
crossref
springer
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 3126
SubjectTerms 13/1
13/109
13/51
13/89
14
38/15
38/91
45/61
631/114/2114
692/4020/4021/1607/1608
692/4020/4021/288/2032
Adult
Aged
Alcoholic beverages
Animal models
Animals
Biopsy
Chromatin Assembly and Disassembly
Chromatin remodeling
Deoxyribonucleic acid
Disease Progression
DNA
DNA Methylation
Epigenesis, Genetic
Epigenetics
Female
Gene expression
Gene Expression Profiling
Gene Expression Regulation
Gene polymorphism
Gene sequencing
Hepatitis
Hepatitis, Alcoholic - genetics
Hepatitis, Alcoholic - pathology
Hepatocyte nuclear factor 4
Hepatocyte Nuclear Factor 4 - genetics
Hepatocyte Nuclear Factor 4 - metabolism
Hepatocytes
Hepatocytes - pathology
Humanities and Social Sciences
Humans
Life Sciences
Liver
Liver - cytology
Liver - pathology
Liver diseases
Male
Middle Aged
multidisciplinary
Phenotypes
Polymorphism, Genetic
Ribonucleic acid
RNA
Science
Sequence Analysis, RNA
Transcription factors
Transcriptomes
Transforming Growth Factor beta1 - genetics
Transforming Growth Factor beta1 - metabolism
Transforming growth factor-b1
SummonAdditionalLinks – databaseName: Health & Medical Collection
  dbid: 7X7
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9QwELagCIkL4k1KQQZxA6tx7MTOCZXHaoWgJyrtzbJjm90KJWU3reDfM-NkUy2FXm3HcjyvT_b4G0JeBwlhAsyG6cYLBt4vZ64KjnlblTaXUflUOuHrcTU_kZ8X5WI8cNuMaZVbn5gcte8aPCM_BL0D1eKl4u_OfjKsGoW3q2MJjZvkFlKXYUqXWqjpjAXZz7WU41uZXOjDjUyeAXANS1xpTOzEo0TbD1FmiUmRVxHn1cTJv25PU1Ca3SN3RzRJjwbx3yc3QvuA3B7qS_5-SE4_hjg4NDo_nsn0rpZty972FHQn0PBrTIVtqd1QS_0aMzVoF-kSIlXf4ck-pqrSaFeYwk5XMHCoq7tqhjFIi_SInMw-ffswZ2NxBdZUle6Zss5qCN-2Vk5W2mmlosqlapwVgkdZNXnkRVUWKgjnfdE0DtCDD7nyQisZxWOy13ZteEqoC0KGPMbaO_AHXtoiKs5tGZxCh1BmhG-32DQj8zgWwPhh0g240GYQiwGxmCQWIzLyZvrmbODduHb0e5TcNBI5s1NDt_5uRhM0eXSgilXhG4CNts7rAO6Mu9pFyQEk-Yy8ArnvzDE_-mKwDTwfx5uQC56Rg61amNHaN-ZSN__drVTJhRa6yMjLqRvMGCVo29CdpylqwBKy1Bl5MijZtBKBlEi1gB61o347S93taVfLRBWOeFIo2J-3W0W9XNb_t3P_-p98Ru4UeXr7xnh1QPb69Xl4DtCsdy-S_f0B4zE0iw
  priority: 102
  providerName: ProQuest
– databaseName: Scholars Portal Journals: Open Access
  dbid: M48
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwELZKERIXxJtAQQZxA0McO7ZzQKg8VitEe2Kl3iw7truLqgR2U9T-e8ZOsii05cQ1tiNrHt98icczCL30HMIEuA1RtWME0C8nVnhLnBGlyXmQLrVOODgU8wX_clQe7aCx3dEgwM2ln3axn9RiffLm7Of5e3D4d_2VcfV2w5O7A1khqQAaYdfQdYhMMjrqwUD3EzKzCj5o-HB35vKlk_iUyvhD1FnGJMmLDPRiIuVfp6kpSM1uo1sDu8T7vTncQTu-uYtu9P0mz--h75986AEOzw9nPN2zJWMb3A6DLXnsz4bU2AabDTbYrWPmBm4DXkLk6tr4pz-mruJgVjGlHa9gYt9nd1X3c2KZpPtoMfv87eOcDM0WSC2E6og01igQmqmk5UJZJWWQOZe1NYzRwEWdB1qIspCeWeeKurbAJpzPpWNK8sAeoN2mbfwjhK1n3OchVM4CPjhuiiApNaW3MgJEmSE6iljXQyXy2BDjRKcTcaZ0rxYNatFJLZpl6NV2zY--Dsc_Z3-ImtvOjDW004N2fawHl9R5sGCaonA10EhT5ZUHeKO2soFTIE0uQy9A75N3zPe_6vgMkJDGk5FfNEN7o1no0Xg1YCTAIC3lFcNSlpQppooMPd8Og1tHDZrGt6fpFRVwC16qDD3sjWy7ExZLJFUMRuTE_CZbnY40q2UqHR75JZMgn9ejof7Z1tXifPw_xPkE3SzydGOOULGHdrv1qX8KhK6zz5KX_gbUxURP
  priority: 102
  providerName: Scholars Portal
– databaseName: Springer Nature OA Free Journals
  dbid: C6C
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3fj9QgECbnGRNfjL-tngaNb0qEQoE-nqubjdF78pJ7I1DA3YtpzW7P6H_vQNs19TwTX8vQEGbmm2kZvkHoZRAQJsBtiG48J4B-lDgZHPFWVpaKqHxunfDpRK5OxYez6uwAldNdmFy0nyktM0xP1WFvdiK7NCQkJJOcEX4NXU_U7cmqF3Kx_6-SGM-1EOP9GMr1X6bOYlCm6ofIsk6FkJezzMvFkn-cmOZAtLyNbo0ZJD4e1nwHHYT2Lrox9JT8eQ-dvwtxADG8OlmKfJeWTK1uewz2EnD4MZa_ttjusMV-m6ozcBfxGqJT36W_-ak8FUe7SWXreAOCQy_dTTPIJCqk--h0-f7zYkXGhgqkkVL3RFlnNYRsWysnpHZaqaioUI2znLMoZEMjK2VVqsCd92XTOMgYfKDKc9jryB-gw7ZrwyOEXeAi0Bhr7wADvLBlVIzZKjiVQKAqEJu22DQj23hqevHV5FNvrs2gFgNqMVkthhfo1X7Ot4Fr45_Sb5Pm9pKJJzs_6LZfzGg3hkYH5idL30CqaGtaB4Aw5moXBYPEyBfoBeh99o7V8UeTngHasXT68Z0V6GgyCzN6-M4ADgLUsUpdMaxUxeDrX5cFer4fBtdNGrRt6C7yK2rIH0SlC_RwMLL9SniiQao5jKiZ-c2WOh9pN-tMD55ySK5gf15Phvp7WVdv5-P_E3-CbpY0338jTB6hw357EZ5Ceta7Z9kffwGRbTJF
  priority: 102
  providerName: Springer Nature
Title Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis
URI https://link.springer.com/article/10.1038/s41467-019-11004-3
https://www.ncbi.nlm.nih.gov/pubmed/31311938
https://www.proquest.com/docview/2258701571
https://www.proquest.com/docview/2775138382
https://www.proquest.com/docview/2259362458
https://hal.univ-lille.fr/hal-03113100
https://pubmed.ncbi.nlm.nih.gov/PMC6635373
https://doaj.org/article/0fb71062dc154a909e1831b9bf41223d
Volume 10
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3fb9MwELZgCIkXxO9ljMog3sBaHDu289iVlapiFQIm9c2yY1stQilauwn-e85OWhamwQsvqWS7lnV3_r5LfL5D6LXnQBOwbYiqHSOAfjmxwlvijChNzoN0qXTC6UxMzvh0Xs6vlPqKMWFteuBWcEd5sDCBKFwNZG-qvPJghNRWNnAK1OYi-gLnXXmZShjMKnh14d0tmZypozVPmAAeDUlZ0gjrMVFK2A_8sojhkNd9zeshk3-cmyY6Gj9A9zs_Eg_b9T9Et3zzCN1tK0v-fIy-vvOhhTI8mY15ulFLtgVvNxisxmP_owuCbbBZY4PdeYzRwKuAF8BRm1X8ph-DVHEwyxi8jpcwsK2ou6zbMTEh0hN0Nj75MpqQrqwCqYVQGyKNNQqI21TScqGskjLInMvaGsZo4KLOAy1EWUjPrHNFXVvwG5zPpWNK8sCeor1m1fh9hK1n3OchVM4CEjhuiiApNaW3MkJBmSG6FbGuu5zjsfTFN53OvpnSrVo0qEUntWiWoTe7_3xvM278dfRx1NxuZMyWnRrAhnRnQ_pfNpShV6D33hyT4Qcd2wDzaDwDuaQZOtyahe72-VoDGgLg0VLe0C1lSZliqsjQy103bOCoQdP41UWaogIvgpcqQ89aI9uthMVkSBWDHtkzv95S-z3NcpGShEdPkkmQz9utof5e1s3iPPgf4nyO7hV5uhtHqDhEe5vzC_8CXLeNHaDbci7hqcbvB-jOcDj9PIXf45PZx0_QOhKjQdrH8Dzl6hcixkLw
linkProvider Directory of Open Access Journals
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3fb9MwELbGEIIXxG8CAwyCJ7AWx07sPCA0GFXHuj5tUt-MHdu0CCWj7YD9U_yNnJ2kUxnsba-xY7m-77675s53CL10HMwEqA2RlWUE2C8lpnCGWF3kOuVe2Ng64WBcDI_4p0k-2UC_-7swIa2y58RI1LapwjfybcAdQIvmgr47_k5C16gQXe1baLSw2HenP-Ev2-Lt3i7I91WWDT4efhiSrqsAqYpCLonQRkuwW7oUhhfSSCG8SLmojGaMel5UqadZkWfCMWNtVlUGzKZ1qbBMCu4ZrHsFXQXDmwaNEhOx-qYTqq1Lzru7OSmT2wsemQj8KBJrsxG2Zv9imwCwatOQhHnewz2fqPlXtDYawcEtdLPzXvFOC7fbaMPVd9C1tp_l6V30ddf5lkDxcDzg8R4v6dvsLjFg1WH3q0u9rbFeYI3tPGSG4MbjKVjGZRMiCSE1Fns9CynzeAYT2z6-s6qdE8ow3UNHl3Ls99Fm3dTuIcLGMe5S70trgH8s15kXlOrcGREIKE8Q7Y9YVV2l89Bw45uKEXcmVSsWBWJRUSyKJej16p3jts7HhbPfB8mtZoYa3fFBM_-iOpVXqTcA_SKzFbipukxLB_RJTWk8p-CU2QS9ALmvrTHcGanwDJiWhsjLD5qgrR4WqmOXhTrThX8PC5FTJpnMEvR8NQy0ESSoa9ecxCVK8F14LhP0oAXZaicslGAqGYyINfitbXV9pJ5NY2ny4L8yAefzpgfq2bb-f5yPLv6Rz9D14eHBSI32xvuP0Y0sjffuCC220OZyfuKegFu4NE-jLmL0-bKV_w8t3HEy
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3fb9MwELbGEIgXxG8CAwyCJ7Aax07sPCA0KFXHRsUDk_bm2bFNi1Ay2g7Yv8Zfx9lJOpXB3vYaO5br--67a-58h9Bzx8FMgNoQWVlGgP1SYgpniNVFrlPuhY2tEz5OivE-_3CQH2yg3_1dmJBW2XNiJGrbVOEb-QBwB9CiuaAD36VFfBqO3hx9J6GDVIi09u00WojsupOf8Pdt8XpnCLJ-kWWj95_fjUnXYYBURSGXRGijJdgwXQrDC2mkEF6kXFRGM0Y9L6rU06zIM-GYsTarKgMm1LpUWCYF9wzWvYQuC5bToGPiQKy-74TK65Lz7p5OyuRgwSMrgU9FYp02wtZsYWwZABZuGhIyz3q7Z5M2_4rcRoM4uoGud54s3m6hdxNtuPoWutL2tjy5jb4OnW_JFI8nIx7v9JK-5e4SA24ddr-6NNwa6wXW2M5DlghuPJ6ClVw2IaoQ0mSx17OQPo9nMLHt6Tur2jmhJNMdtH8hx34XbdZN7e4jbBzjLvW-tAa4yHKdeUGpzp0RgYzyBNH-iFXVVT0PzTe-qRh9Z1K1YlEgFhXFoliCXq7eOWprfpw7-22Q3GpmqNcdHzTzL6pTf5V6A2pQZLYCl1WXaemASqkpjecUHDSboGcg97U1xtt7KjwD1qUhCvODJmirh4XqmGahTvXi38NCADYlk1mCnq6GgUKCBHXtmuO4RAl-DM9lgu61IFvthIVyTCWDEbEGv7Wtro_Us2ksUx58WSbgfF71QD3d1v-P88H5P_IJugpqr_Z2JrsP0bUsjVfwCC220OZyfuwegYe4NI-jKmJ0eNG6_weqLnVo
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Defective+HNF4alpha-dependent+gene+expression+as+a+driver+of+hepatocellular+failure+in+alcoholic+hepatitis&rft.jtitle=Nature+communications&rft.au=Josepmaria+Argemi&rft.au=Maria+U.+Latasa&rft.au=Stephen+R.+Atkinson&rft.au=Ilya+O.+Blokhin&rft.date=2019-07-16&rft.pub=Nature+Portfolio&rft.eissn=2041-1723&rft.volume=10&rft.issue=1&rft.spage=1&rft.epage=19&rft_id=info:doi/10.1038%2Fs41467-019-11004-3&rft.externalDBID=DOA&rft.externalDocID=oai_doaj_org_article_0fb71062dc154a909e1831b9bf41223d
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2041-1723&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2041-1723&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2041-1723&client=summon