Safety and tolerability of chikungunya virus-like particle vaccine in healthy adults: a phase 1 dose-escalation trial - Chang, Lee-Jah; Dowd, Kimberly A; Mendoza, Floreliz H; Saunders, Jamie G; Sitar, Sandra; Plummer, Sarah H; Yamshchikov, Galina; Sarwar, Uzma N; Hu, Zonghui; Enama, Mary E; Bailer, Robert T; Koup, Richard A; et al. (The Lancet (British edition), 2014)
Keywords: Adolescent; Adult; Allergies; Antibodies, Neutralizing - analysis; Biological and medical sciences; Biomedical research; Chikungunya virus; Chikungunya virus - immunology; Clinical trials; Enzyme-Linked Immunosorbent Assay; Female; General aspects; Humans; Immune system; Immune Tolerance; Immunogenicity; Infectious diseases; Internal Medicine; Male; Medical sciences; Middle Aged; Safety; Vaccination; Vaccines; Vector-borne diseases; Viral infections; Viral Vaccines - administration & dosage; Viruses; USA; ISEW, Southeast Asia; ASW, Caribbean Sea; Africa; Human; Healthy subject; Virus like particle; Vaccination; Togaviridae; Vaccine; Virus; Medicine; Increasing dose; Chikungunya virus; Phase I trial; Alphavirus; Adult; Safety