The sphingosine-1-phosphate transporter Spns2 expressed on endothelial cells regulates lymphocyte trafficking in mice

• Published in: The Journal of clinical investigation Vol. 122; no. 4; pp. 1416 - 1426
• Main Authors: Fukuhara, Shigetomo, Simmons, Szandor, Kawamura, Shunsuke, Inoue, Asuka, Orba, Yasuko, Tokudome, Takeshi, Sunden, Yuji, Arai, Yuji, Moriwaki, Kazumasa, Ishida, Junji, Uemura, Akiyoshi, Kiyonari, Hiroshi, Abe, Takaya, Fukamizu, Akiyoshi, Hirashima, Masanori, Sawa, Hirofumi, Aoki, Junken, Ishii, Masaru, Mochizuki, Naoki
• Format: Journal Article
• Language: English
• Published: United States American Society for Clinical Investigation 01.04.2012
• Subjects: Animals; Anion Transport Proteins - deficiency; Anion Transport Proteins - genetics; Anion Transport Proteins - physiology; Autoimmune diseases; B-Lymphocyte Subsets - cytology; Biological Transport; Biomedical research; Blood; Blood platelets; Bone marrow; Cell Movement - physiology; Cells, Cultured - secretion; Chimera; Endothelial Cells - metabolism; Endothelium; Gene expression; Genetic aspects; Genetic regulation; Hematology; Hemoglobin; Kinases; Lymphatic system; Lymphocyte Count; Lymphocytes; Lymphocytes, Null - cytology; Lymphoid Tissue - cytology; Lymphopoiesis; Lysophospholipids - blood; Lysophospholipids - metabolism; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Knockout; Physiology; Properties; Specific Pathogen-Free Organisms; Sphingosine; Sphingosine - analogs & derivatives; Sphingosine - blood; Sphingosine - metabolism; T-Lymphocyte Subsets - cytology; Thymocytes - cytology; Thymus gland; Transendothelial and Transepithelial Migration - physiology; Japan

The bioactive lysophospholipid mediator sphingosine-1-phosphate (S1P) promotes the egress of newly formed T cells from the thymus and the release of immature B cells from the bone marrow. It has remained unclear, however, where and how S1P is released. Here, we show that in mice, the S1P transporter...