Low-dose in vivo protection and neutralization across SARS-CoV-2 variants by monoclonal antibody combinations

• Published in: Nature immunology Vol. 22; no. 12; pp. 1503 - 1514
• Main Authors: Dussupt, Vincent, Sankhala, Rajeshwer S., Mendez-Rivera, Letzibeth, Townsley, Samantha M., Schmidt, Fabian, Wieczorek, Lindsay, Lal, Kerri G., Donofrio, Gina C., Tran, Ursula, Jackson, Nathaniel D., Zaky, Weam I., Zemil, Michelle, Tritsch, Sarah R., Chen, Wei-Hung, Martinez, Elizabeth J., Ahmed, Aslaa, Choe, Misook, Chang, William C., Hajduczki, Agnes, Jian, Ningbo, Peterson, Caroline E., Rees, Phyllis A., Rutkowska, Magdalena, Slike, Bonnie M., Selverian, Christopher N., Swafford, Isabella, Teng, I-Ting, Thomas, Paul V., Zhou, Tongqing, Smith, Clayton J., Currier, Jeffrey R., Kwong, Peter D., Rolland, Morgane, Davidson, Edgar, Doranz, Benjamin J., Mores, Christopher N., Hatziioannou, Theodora, Reiley, William W., Bieniasz, Paul D., Paquin-Proulx, Dominic, Gromowski, Gregory D., Polonis, Victoria R., Michael, Nelson L., Modjarrad, Kayvon, Joyce, M. Gordon, Krebs, Shelly J.
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.12.2021; Nature Publishing Group; Nature Research, Springer Nature
• Subjects: 60 APPLIED LIFE SCIENCES; 631/250/2499; 631/250/255/2514; 692/420/2780/2152/2153/1291; ACE2; Amino Acid Sequence; Angiotensin; Angiotensin-converting enzyme 2; Animals; antibodies; Antibodies, Monoclonal - administration & dosage; Antibodies, Monoclonal - immunology; Antibodies, Monoclonal - metabolism; Antibodies, Neutralizing - chemistry; Antibodies, Neutralizing - immunology; Antibodies, Neutralizing - metabolism; Antibodies, Viral - immunology; Antibodies, Viral - metabolism; antimicrobial responses; Binding Sites - genetics; Biomedical and Life Sciences; Biomedicine; Coronaviruses; COVID-19; COVID-19 - immunology; COVID-19 - metabolism; COVID-19 - prevention & control; Disease Models, Animal; Dosage and administration; Dose-Response Relationship, Drug; Drug therapy, Combination; Epitope Mapping; Epitopes - chemistry; Epitopes - immunology; Epitopes - metabolism; Humans; Immunology; Inactivation; Infectious Diseases; Methods; Mice, Transgenic; Monoclonal antibodies; Neutralization; Neutralization Tests; Peptidyl-dipeptidase A; Protein Binding; Protein Conformation; SARS-CoV-2 - genetics; SARS-CoV-2 - immunology; SARS-CoV-2 - metabolism; Sequence Homology, Amino Acid; Severe acute respiratory syndrome coronavirus 2; Spike glycoprotein; Spike Glycoprotein, Coronavirus - genetics; Spike Glycoprotein, Coronavirus - immunology; Spike Glycoprotein, Coronavirus - metabolism; Spike protein; Survival Analysis; viral infection; United States

Prevention of viral escape and increased coverage against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern require therapeutic monoclonal antibodies (mAbs) targeting multiple sites of vulnerability on the coronavirus spike glycoprotein. Here we identify several potent...