Low-dose in vivo protection and neutralization across SARS-CoV-2 variants by monoclonal antibody combinations - Dussupt, Vincent; Sankhala, Rajeshwer S.; Mendez-Rivera, Letzibeth; Townsley, Samantha M.; Schmidt, Fabian; Wieczorek, Lindsay; Lal, Kerri G.; Donofrio, Gina C.; Tran, Ursula; Jackson, Nathaniel D.; Zaky, Weam I.; Zemil, Michelle; et al. (Nature immunology, 2021)
Keywords: 60 APPLIED LIFE SCIENCES; 631/250/2499; 631/250/255/2514; 692/420/2780/2152/2153/1291; ACE2; Amino Acid Sequence; Angiotensin; Angiotensin-converting enzyme 2; Animals; antibodies; Antibodies, Monoclonal - administration & dosage; Antibodies, Monoclonal - immunology; Antibodies, Monoclonal - metabolism; Antibodies, Neutralizing - chemistry; Antibodies, Neutralizing - immunology; Antibodies, Neutralizing - metabolism; Antibodies, Viral - immunology; Antibodies, Viral - metabolism; antimicrobial responses; Binding Sites - genetics; Biomedical and Life Sciences; Biomedicine; Coronaviruses; COVID-19; COVID-19 - immunology; COVID-19 - metabolism; COVID-19 - prevention & control; Disease Models, Animal; Dosage and administration; Dose-Response Relationship, Drug; Drug therapy, Combination; Epitope Mapping; Epitopes - chemistry; Epitopes - immunology; Epitopes - metabolism; Humans; Immunology; Inactivation; Infectious Diseases; Methods; Mice, Transgenic; Monoclonal antibodies; Neutralization; Neutralization Tests; Peptidyl-dipeptidase A; Protein Binding; Protein Conformation; SARS-CoV-2 - genetics; SARS-CoV-2 - immunology; SARS-CoV-2 - metabolism; Sequence Homology, Amino Acid; Severe acute respiratory syndrome coronavirus 2; Spike glycoprotein; Spike Glycoprotein, Coronavirus - genetics; Spike Glycoprotein, Coronavirus - immunology; Spike Glycoprotein, Coronavirus - metabolism; Spike protein; Survival Analysis; viral infection; United States