Immunocompromised and immunocompetent mouse models for head and neck squamous cell carcinoma

• Published in: OncoTargets and therapy Vol. 9; no. Issue 1; pp. 545 - 555
• Main Authors: Lei, Zhen-Ge, Ren, Xiao-Hua, Wang, Sha-Sha, Liang, Xin-Hua, Tang, Ya-Ling
• Format: Journal Article
• Language: English
• Published: New Zealand Dove Medical Press Limited 01.01.2016; Taylor & Francis Ltd; Dove Medical Press
• Subjects: Animal research models; Cancer research; Cancer therapies; Care and treatment; Development and progression; Diabetes; Diagnosis; Esophagus; Genetic aspects; Genetic engineering; Genotypes; Head & neck cancer; Head and neck cancer; Head and neck squamous cell carcinoma (HNSCC); Health aspects; Hospitals; Human papillomavirus; Immunocompetence; Immunocompetent models; Immunocompromised host; Immunocompromised models; Inflammation; Laboratories; Maxillofacial surgery; Medical prognosis; Medical research; Metastasis; Mouse models; Physiological aspects; Radiation therapy; Review; Rodents; Squamous cell carcinoma; Surgery; Transgenic animals; Transgenic models; Tumorigenesis; Tumors; China; mouse models; immunocompetent models; transgenic models; HNSCC; immunocompromised models; head and neck squamous cell carcinoma
• ISSN: 1178-6930; 1178-6930
• DOI: 10.2147/OTT.S95633

Mouse models can closely mimic human oral squamous epithelial carcinogenesis, greatly expand the in vivo research possibilities, and play a critical role in the development of diagnosis, monitoring, and treatment of head and neck squamous cell carcinoma. With the development of the recent research on the contribution of immunity/inflammation to cancer initiation and progression, mouse models have been divided into two categories, namely, immunocompromised and immunocompetent mouse models. And thus, this paper will review these two kinds of models applied in head and neck squamous cell carcinoma to provide a platform to understand the complicated histological, molecular, and genetic changes of oral squamous epithelial tumorigenesis.