High Prevalence and Disease Correlation of Autoantibodies Against p40 Encoded by Long Interspersed Nuclear Elements in Systemic Lupus Erythematosus

• Published in: Arthritis & rheumatology (Hoboken, N.J.) Vol. 72; no. 1; pp. 89 - 99
• Main Authors: Carter, Victoria, LaCava, John, Taylor, Martin S., Liang, Shu Ying, Mustelin, Cecilia, Ukadike, Kennedy C., Bengtsson, Anders, Lood, Christian, Mustelin, Tomas
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.01.2020
• Subjects: Age Factors; Antibodies; Antibodies, Antinuclear - immunology; Autoantibodies; Autoantibodies - immunology; Autoantigens; Autoimmune diseases; Autoimmunity; Case-Control Studies; Chronic conditions; Clinical Medicine; Complement C1q - immunology; Complement C3 - immunology; Complement component C1q; Complement component C3; Deoxyribonucleic acid; Disease control; DNA; DNA-Binding Proteins - immunology; Endonuclease; Enzyme-linked immunosorbent assay; Humans; Immune response; Immune system; Immunoblotting; Immunoglobulin G; Immunoglobulins; Interferon; Klinisk medicin; Long Interspersed Nucleotide Elements - immunology; Lupus; Lupus Erythematosus, Systemic - immunology; Lupus Nephritis - immunology; Medical and Health Sciences; Medicin och hälsovetenskap; Nephritis; p40 Protein; Pathogenesis; Patients; Proteins; Remission; Ribonucleic acid; RNA; RNA-binding protein; RNA-directed DNA polymerase; Scleroderma; Scleroderma, Systemic - immunology; Severity of Illness Index; Systemic lupus erythematosus; Systemic sclerosis

Objective Long interspersed nuclear element 1 (LINE‐1) encodes 2 proteins, the RNA binding protein p40 and endonuclease and reverse transcriptase (open‐reading frame 2p [ORF2p]), which are both required for LINE‐1 to retrotranspose. In cells expressing LINE‐1, these proteins assemble with LINE‐1 RNA...