ISG20: an enigmatic antiviral RNase targeting multiple viruses

• Published in: FEBS open bio Vol. 12; no. 6; pp. 1096 - 1111
• Main Authors: Deymier, Séverine, Louvat, Camille, Fiorini, Francesca, Cimarelli, Andrea
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.06.2022; Wiley Open Access/Elsevier; John Wiley and Sons Inc; Wiley
• Subjects: Amino acids; Antiviral Agents - pharmacology; antiviral proteins; Apoptosis; Chromosomes; Dengue fever; DNA; Enzymes; epitranscriptomic modifications; Estrogens; eukaryotic cells; Exoribonucleases - genetics; Genes; Hepatitis B; Infections; Interferon; Interferons - metabolism; ISG20; Kinases; Life Sciences; mechanism of action; Molecular modelling; Pathogens; Pattern recognition; Prokaryotes; prokaryotic cells; Proteins; Review; Reviews; Ribonuclease; ribonucleases; RNA; RNA polymerase; RNA, Viral - genetics; RNase; translational inhibition; virus inhibition; Virus Replication - physiology; Viruses; Viruses - genetics; Viruses - metabolism; West Nile virus; ISG20; translational inhibition; virus inhibition; epitranscriptomic modifications; interferon; RNase; ISG20, RNase, epitranscriptomic modifications, interferon, translational inhibition, virus inhibition

Interferon‐stimulated gene 20 kDa protein (ISG20) is a relatively understudied antiviral protein capable of inhibiting a broad spectrum of viruses. ISG20 exhibits strong RNase properties, and it belongs to the large family of DEDD exonucleases, present in both prokaryotes and eukaryotes. ISG20 was i...