Successful Control of Dasatinib-related Chylothorax by the Japanese Herbal Medicine "Goreisan"

• Published in: Internal Medicine Vol. 58; no. 21; pp. 3139 - 3141
• Main Authors: Sasaki, Hisashi, Kimizuka, Yoshifumi, Ogata, Hiraku, Okada, Yosuke, Ota, Shinichiro, Sano, Tomoya, Watanabe, Chie, Maki, Yohei, Yamamoto, Takayuki, Tagami, Yoichi, Miyata, Jun, Hayashi, Nobuyoshi, Fujikura, Yuji, Kawana, Akihiko
• Format: Journal Article
• Language: English
• Published: Japan The Japanese Society of Internal Medicine 01.11.2019; Japan Science and Technology Agency
• Subjects: Adult; Aged; Aged, 80 and over; Antineoplastic Agents - adverse effects; aquaporin; Case Report; Chronic myeloid leukemia; chylothorax; Chylothorax - chemically induced; Chylothorax - diagnostic imaging; Chylothorax - drug therapy; dasatinib; Dasatinib - adverse effects; Diuretics; Female; Goreisan; Herbal medicine; Humans; Internal medicine; Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy; Male; Medicine, Kampo; Middle Aged; Myeloid leukemia; Phytotherapy; Plant Extracts - therapeutic use; Pleural Effusion - chemically induced; Pleural Effusion - diagnostic imaging; Radiography, Thoracic; Steroid hormones; Water flow; chronic myeloid leukemia; Goreisan; dasatinib; aquaporin; chylothorax

Dasatinib-related chylothorax is a rare adverse event, and the mechanism underlying its occurrence is still not fully understood. We herein report the case of a 73-year-old woman with chronic myeloid leukemia (CML) who developed dasatinib-related chylothorax refractory to conventional treatments, ex...