Successful Control of Dasatinib-related Chylothorax by the Japanese Herbal Medicine "Goreisan"

Dasatinib-related chylothorax is a rare adverse event, and the mechanism underlying its occurrence is still not fully understood. We herein report the case of a 73-year-old woman with chronic myeloid leukemia (CML) who developed dasatinib-related chylothorax refractory to conventional treatments, ex...

Full description

Saved in:
Bibliographic Details
Published inInternal Medicine Vol. 58; no. 21; pp. 3139 - 3141
Main Authors Sasaki, Hisashi, Kimizuka, Yoshifumi, Ogata, Hiraku, Okada, Yosuke, Ota, Shinichiro, Sano, Tomoya, Watanabe, Chie, Maki, Yohei, Yamamoto, Takayuki, Tagami, Yoichi, Miyata, Jun, Hayashi, Nobuyoshi, Fujikura, Yuji, Kawana, Akihiko
Format Journal Article
LanguageEnglish
Published Japan The Japanese Society of Internal Medicine 01.11.2019
Japan Science and Technology Agency
Subjects
Adult
Aged
Aged, 80 and over
Antineoplastic Agents - adverse effects
aquaporin
Case Report
Chronic myeloid leukemia
chylothorax
Chylothorax - chemically induced
Chylothorax - diagnostic imaging
Chylothorax - drug therapy
dasatinib
Dasatinib - adverse effects
Diuretics
Female
Goreisan
Herbal medicine
Humans
Internal medicine
Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy
Male
Medicine, Kampo
Middle Aged
Myeloid leukemia
Phytotherapy
Plant Extracts - therapeutic use
Pleural Effusion - chemically induced
Pleural Effusion - diagnostic imaging
Radiography, Thoracic
Steroid hormones
Water flow
chronic myeloid leukemia
Goreisan
dasatinib
aquaporin
chylothorax
Online AccessGet full text

Cover

More Information
Summary:Dasatinib-related chylothorax is a rare adverse event, and the mechanism underlying its occurrence is still not fully understood. We herein report the case of a 73-year-old woman with chronic myeloid leukemia (CML) who developed dasatinib-related chylothorax refractory to conventional treatments, except for steroids. To the best of our knowledge, this is the first case of dasatinib-related chylothorax which was successfully controlled by combining diuretics with the Japanese herbal medicine "Goreisan." "Goreisan" is known to inhibit aquaporin channels and regulate the water flow. Our findings showed that "Goreisan" is an effective treatment option for uncontrollable dasatinib-related chylothorax.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
content type line 14
ObjectType-Report-1
ObjectType-Review-5
ObjectType-Feature-4
content type line 23
ObjectType-Article-3
Correspondence to Dr.　Yoshifumi Kimizuka, ykimizuka@ndmc.ac.jp
ISSN:0918-2918
1349-7235
1349-7235
DOI:10.2169/internalmedicine.3002-19