Regional Myocardial Sympathetic Denervation Predicts the Risk of Sudden Cardiac Arrest in Ischemic Cardiomyopathy

• Published in: Journal of the American College of Cardiology Vol. 63; no. 2; pp. 141 - 149
• Main Authors: Fallavollita, James A., MD, Heavey, Brendan M., MPH, Luisi, Andrew J., MD, Michalek, Suzanne M., MS, Baldwa, Sunil, MBBS, Mashtare, Terry L., PhD, Hutson, Alan D., PhD, deKemp, Robert A., PhD, Haka, Michael S., PhD, Sajjad, Munawwar, PhD, Cimato, Thomas R., MD, Curtis, Anne B., MD, Cain, Michael E., MD, Canty, John M., MD
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 21.01.2014; Elsevier; Elsevier Limited
• Subjects: 11C-meta-hydroxyephedrine; Aged; Biological and medical sciences; Cardiac arrest; Cardiology; Cardiology. Vascular system; Cardiomyopathy; Cardiovascular; Cardiovascular disease; Confidence intervals; Death, Sudden, Cardiac - epidemiology; Death, Sudden, Cardiac - etiology; Death, Sudden, Cardiac - prevention & control; Female; Follow-Up Studies; Heart; Heart attacks; Heart failure; Hospice care; Humans; Incidence; Internal Medicine; Ischemia; Male; Medical imaging; Medical sciences; Mortality; Myocardial Ischemia - mortality; Myocardial Ischemia - physiopathology; Myocardial Ischemia - surgery; myocardial viability; Myocarditis. Cardiomyopathies; Positron-Emission Tomography; Primary Prevention - methods; Prospective Studies; Retention; sudden cardiac arrest; Survival Rate - trends; Sympathectomy - methods; sympathetic denervation; Time Factors; Treatment Outcome; United States - epidemiology; Ventricular Function, Left; United States; magnetic resonance imaging; BNP; left ventricle; MIBG; MRI; LVEF; 11C-HED; LV; left ventricular ejection fraction; 18FDG; myocardial viability; 18F-2-deoxyglucose; sudden cardiac arrest; ventricular fibrillation; sympathetic denervation; ICD; 11C-meta-hydroxyephedrine; SCA; VF; B-type natriuretic peptide; 123I-meta-iodobenzylguanidine; ventricular tachycardia; implantable cardiac defibrillator; positron emission tomography; PET; VT; Cardiocirculatory arrest; Cardiomyopathy; Acute; Prediction; Cardiovascular disease; Risk; Sudden; Regional; Myocardial disease; Ischemia; Heart disease; Risk factor; Myocardium; Circulatory system; Cardiology; Predictive factor; Denervation; FDG; C-HED; C-meta-hydroxyephedrine; I-meta-iodobenzylguanidine; F-2-deoxyglucose

Objectives The PAREPET (Prediction of ARrhythmic Events with Positron Emission Tomography) study sought to test the hypothesis that quantifying inhomogeneity in myocardial sympathetic innervation could identify patients at highest risk for sudden cardiac arrest (SCA). Background Left ventricular eje...