The Onco-Embryonic Antigen ROR1 Is Expressed by a Variety of Human Cancers

• Published in: The American journal of pathology Vol. 181; no. 6; pp. 1903 - 1910
• Main Authors: Zhang, Suping, Chen, Liguang, Wang-Rodriguez, Jessica, Zhang, Ling, Cui, Bing, Frankel, Wendy, Wu, Rongrong, Kipps, Thomas J.
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Elsevier Inc 01.12.2012; American Society for Investigative Pathology
• Subjects: Adult; Animals; Biological and medical sciences; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; CHO Cells; Cricetinae; Cricetulus; Cyclic AMP Response Element-Binding Protein - metabolism; Enzyme Activation; Gene Expression Regulation, Neoplastic; Humans; Investigative techniques, diagnostic techniques (general aspects); Medical sciences; Neoplasms - genetics; Neoplasms - metabolism; Neoplasms - pathology; Oncogene Proteins - genetics; Oncogene Proteins - metabolism; Pathology; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques; Proto-Oncogene Proteins c-akt - metabolism; Receptor Tyrosine Kinase-like Orphan Receptors - genetics; Receptor Tyrosine Kinase-like Orphan Receptors - metabolism; Short Communication; Antigen; Human; Anatomic pathology; Malignant tumor; Cancer

ROR1 is an orphan-receptor tyrosine-kinase-like surface antigen that is expressed by many tissues during embryogenesis, some B-cell malignancies, and various cancer cell lines but not by virtually all normal adult tissues. Here, we report that large proportions of many different human cancers also e...