Serum Tenascin-C as a Novel Predictor for Risk of Coronary Artery Lesion and Resistance to Intravenous Immunoglobulin in Kawasaki Disease　– A Multicenter Retrospective Study

• Published in: Circulation Journal Vol. 80; no. 11; pp. 2376 - 2381
• Main Authors: Yoshida, Toshimichi, Imanaka-Yoshida, Kyoko, Abe, Jun, Ichida, Fukiko, Suda, Kenji, Nakaoka, Hideyuki, Yoshikane, Yukako, Matsushita, Takeji, Okuma, Yoshiaki, Shiraishi, Isao, Hiroe, Michiaki, Katsube, Yasuhiro, Shichino, Hiroyuki, Mitani, Yoshihide
• Format: Journal Article
• Language: English
• Published: Japan The Japanese Circulation Society 2016
• Subjects: Biomarkers; Biomarkers - blood; Child; Child, Preschool; Coronary artery lesions; Coronary Vessels - metabolism; Drug Resistance; Female; Humans; Immunoglobulins, Intravenous - administration & dosage; Infant; Intravenous immunoglobulin (IVIG) resistance; Kawasaki disease; Male; Mucocutaneous Lymph Node Syndrome - blood; Mucocutaneous Lymph Node Syndrome - drug therapy; Retrospective Studies; Risk Factors; Tenascin - blood; Tenascin-C
• ISSN: 1346-9843; 1347-4820; 1347-4820
• DOI: 10.1253/circj.CJ-16-0563

Background:Tenascin-C (TN-C) is an extracellular matrix glycoprotein that is heavily upregulated at sites of inflammation. We conducted a retrospective study to assess the utility of TN-C as a novel biomarker to predict the risk of developing coronary artery lesions (CAL) and resistance to intraveno...