Higher body weight patients on clopidogrel maintenance therapy have lower active metabolite concentrations, lower levels of platelet inhibition, and higher rates of poor responders than low body weight patients - Wagner, Henrik; Angiolillo, Dominick J.; ten Berg, Jurrien M.; Bergmeijer, Thomas O.; Jakubowski, Joseph A.; Small, David S.; Moser, Brian A.; Zhou, Chunmei; Brown, Patricia; James, Stefan; Winters, Kenneth J.; Erlinge, David (Journal of thrombosis and thrombolysis, 2014)
Keywords: Adolescent; Adult; Aged; Blood Platelets - metabolism; Body Weight; Cardiac and Cardiovascular Systems; Cardiology; Cardiology and Cardiovascular Disease; Clinical Medicine; Clopidogrel; Female; Hematology; Humans; Kardiologi; Kardiologi och kardiovaskulära sjukdomar; Klinisk medicin; Male; Medical and Health Sciences; Medicin och hälsovetenskap; Medicine; Medicine & Public Health; Middle Aged; Pharmacodynamics; Pharmacokinetics; Platelet Aggregation - drug effects; Platelet Aggregation Inhibitors - administration & dosage; Platelet Aggregation Inhibitors - pharmacokinetics; Ticlopidine - administration & dosage; Ticlopidine - analogs & derivatives; Ticlopidine - pharmacokinetics; Clopidogrel; Pharmacodynamics; Pharmacokinetics; Body weight