Isocaloric high-fat feeding directs hepatic metabolism to handling of nutrient imbalance promoting liver fat deposition

Background/Objectives: Consumption of fat-rich foods is associated with obesity and related alterations. However, there is a group of individuals, the metabolically obese normal-weight (MONW) subjects, who present normal body weight but have metabolic features characteristic of the obese status, inc...

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Published inInternational Journal of Obesity Vol. 40; no. 8; pp. 1250 - 1259
Main Authors Díaz-Rúa, R, van Schothorst, E M, Keijer, J, Palou, A, Oliver, P
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 01.08.2016
Nature Publishing Group
Subjects
13/1
14/63
38/61
631/1647/767/1424
631/443/319/2723
631/45/287/1182
692/53
692/699/1702/393
692/700/2814
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Adaptation
Adiposity
Animal Nutritional Physiological Phenomena
Animals
Biomarkers
Blotting, Western
Body Weight
Carbohydrates
Cholesterol
Cholesterol - blood
Cholesterol - metabolism
Deposition
Diet
Diet, High-Fat - adverse effects
Disease Models, Animal
Down-Regulation
Energy Intake
Epidemiology
Fat metabolism
Fatty liver
Fatty Liver - etiology
Fatty Liver - genetics
Fatty Liver - metabolism
Fatty Liver - pathology
Food consumption
Fysiologie van Mens en Dier
Gene expression
Genomes
Health aspects
Health Promotion and Disease Prevention
High fat diet
Human and Animal Physiology
Hyperphagia
Immunohistochemistry
Insulin resistance
Internal Medicine
Keratins, Type I - analysis
Keratins, Type I - genetics
Ketogenic diet
Laboratories
Leerstoelgroep Fysiologie van mens en dier
Lipid metabolism
Lipid Metabolism - genetics
Lipids
Liver
Liver - chemistry
Liver - metabolism
Liver cancer
Liver diseases
Male
Medicine
Medicine & Public Health
Metabolic Diseases
Metabolic disorders
Metabolism
Molecular biology
Nutrition research
Obesity
Obesity - metabolism
original-article
Overweight
Physiological aspects
Public Health
Rats
Rats, Wistar
Risk
Risk factors
Transcriptome
Transcriptomes
Triglycerides
Up-Regulation
VLAG
WIAS
Netherlands
Spain
Majorca
United States > US
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Abstract Background/Objectives: Consumption of fat-rich foods is associated with obesity and related alterations. However, there is a group of individuals, the metabolically obese normal-weight (MONW) subjects, who present normal body weight but have metabolic features characteristic of the obese status, including fat deposition in critical tissues such as liver, recognized as a major cause for the promotion of metabolic diseases. Our aim was to better understand metabolic alterations present in liver of MONW rats applying whole genome transcriptome analysis. Methods: Wistar rats were chronically fed a high-fat diet isocaloric relative to Control animals to avoid the hyperphagia and overweight and to mimic MONW features. Liver transcriptome analysis of both groups was performed. Results: Sustained intake of an isocaloric high-fat diet had a deep impact on the liver transcriptome, mainly affecting lipid metabolism. Although serum cholesterol levels were not affected, circulating triacylglycerols were lower, and metabolic adaptations at gene expression level indicated adaptation toward handling the increased fat content of the diet, an increased triacylglycerol and cholesterol deposition in liver of MONW rats was observed. Moreover, gene expression pointed to increased risk of liver injury. One of the top upregulated genes in this tissue was Krt23 , a marker of hepatic disease in humans that was also increased at the protein level. Conclusion: Long-term intake of a high-fat diet, even in the absence of overweight/obesity or increase in classical blood risk biomarkers, promotes a molecular environment leading to hepatic lipid accumulation and increasing the risk of suffering from hepatic diseases.
AbstractList Background/Objectives:Consumption of fat-rich foods is associated with obesity and related alterations. However, there is a group of individuals, the metabolically obese normal-weight (MONW) subjects, who present normal body weight but have metabolic features characteristic of the obese status, including fat deposition in critical tissues such as liver, recognized as a major cause for the promotion of metabolic diseases. Our aim was to better understand metabolic alterations present in liver of MONW rats applying whole genome transcriptome analysis.Methods:Wistar rats were chronically fed a high-fat diet isocaloric relative to Control animals to avoid the hyperphagia and overweight and to mimic MONW features. Liver transcriptome analysis of both groups was performed.Results:Sustained intake of an isocaloric high-fat diet had a deep impact on the liver transcriptome, mainly affecting lipid metabolism. Although serum cholesterol levels were not affected, circulating triacylglycerols were lower, and metabolic adaptations at gene expression level indicated adaptation toward handling the increased fat content of the diet, an increased triacylglycerol and cholesterol deposition in liver of MONW rats was observed. Moreover, gene expression pointed to increased risk of liver injury. One of the top upregulated genes in this tissue was Krt23, a marker of hepatic disease in humans that was also increased at the protein level.Conclusion:Long-term intake of a high-fat diet, even in the absence of overweight/obesity or increase in classical blood risk biomarkers, promotes a molecular environment leading to hepatic lipid accumulation and increasing the risk of suffering from hepatic diseases.
BACKGROUND/OBJECTIVES: Consumption of fat-rich foods is associated with obesity and related alterations. However, there is a group of individuals, the metabolically obese normal-weight (MONW) subjects, who present normal body weight but have metabolic features characteristic of the obese status, including fat deposition in critical tissues such as liver, recognized as a major cause for the promotion of metabolic diseases. Our aim was to better understand metabolic alterations present in liver of MONW rats applying whole genome transcriptome analysis. METHODS: Wistar rats were chronically fed a high-fat diet isocaloric relative to Control animals to avoid the hyperphagia and overweight and to mimic MONW features. Liver transcriptome analysis of both groups was performed. RESULTS: Sustained intake of an isocaloric high-fat diet had a deep impact on the liver transcriptome, mainly affecting lipid metabolism. Although serum cholesterol levels were not affected, circulating triacylglycerols were lower, and metabolic adaptations at gene expression level indicated adaptation toward handling the increased fat content of the diet, an increased triacylglycerol and cholesterol deposition in liver of MONW rats was observed. Moreover, gene expression pointed to increased risk of liver injury. One of the top upregulated genes in this tissue was Krt23, a marker of hepatic disease in humans that was also increased at the protein level. CONCLUSION: Long-term intake of a high-fat diet, even in the absence of overweight/obesity or increase in classical blood risk biomarkers, promotes a molecular environment leading to hepatic lipid accumulation and increasing the risk of suffering from hepatic diseases. International Journal of Obesity (2016) 40, 1250-1259; doi: 10.1038/ijo.2016.47
Consumption of fat-rich foods is associated with obesity and related alterations. However, there is a group of individuals, the metabolically obese normal-weight (MONW) subjects, who present normal body weight but have metabolic features characteristic of the obese status, including fat deposition in critical tissues such as liver, recognized as a major cause for the promotion of metabolic diseases. Our aim was to better understand metabolic alterations present in liver of MONW rats applying whole genome transcriptome analysis. Wistar rats were chronically fed a high-fat diet isocaloric relative to Control animals to avoid the hyperphagia and overweight and to mimic MONW features. Liver transcriptome analysis of both groups was performed. Sustained intake of an isocaloric high-fat diet had a deep impact on the liver transcriptome, mainly affecting lipid metabolism. Although serum cholesterol levels were not affected, circulating triacylglycerols were lower, and metabolic adaptations at gene expression level indicated adaptation toward handling the increased fat content of the diet, an increased triacylglycerol and cholesterol deposition in liver of MONW rats was observed. Moreover, gene expression pointed to increased risk of liver injury. One of the top upregulated genes in this tissue was Krt23, a marker of hepatic disease in humans that was also increased at the protein level. Long-term intake of a high-fat diet, even in the absence of overweight/obesity or increase in classical blood risk biomarkers, promotes a molecular environment leading to hepatic lipid accumulation and increasing the risk of suffering from hepatic diseases.
Consumption of fat-rich foods is associated with obesity and related alterations. However, there is a group of individuals, the metabolically obese normal-weight (MONW) subjects, who present normal body weight but have metabolic features characteristic of the obese status, including fat deposition in critical tissues such as liver, recognized as a major cause for the promotion of metabolic diseases. Our aim was to better understand metabolic alterations present in liver of MONW rats applying whole genome transcriptome analysis.BACKGROUND/OBJECTIVESConsumption of fat-rich foods is associated with obesity and related alterations. However, there is a group of individuals, the metabolically obese normal-weight (MONW) subjects, who present normal body weight but have metabolic features characteristic of the obese status, including fat deposition in critical tissues such as liver, recognized as a major cause for the promotion of metabolic diseases. Our aim was to better understand metabolic alterations present in liver of MONW rats applying whole genome transcriptome analysis.Wistar rats were chronically fed a high-fat diet isocaloric relative to Control animals to avoid the hyperphagia and overweight and to mimic MONW features. Liver transcriptome analysis of both groups was performed.METHODSWistar rats were chronically fed a high-fat diet isocaloric relative to Control animals to avoid the hyperphagia and overweight and to mimic MONW features. Liver transcriptome analysis of both groups was performed.Sustained intake of an isocaloric high-fat diet had a deep impact on the liver transcriptome, mainly affecting lipid metabolism. Although serum cholesterol levels were not affected, circulating triacylglycerols were lower, and metabolic adaptations at gene expression level indicated adaptation toward handling the increased fat content of the diet, an increased triacylglycerol and cholesterol deposition in liver of MONW rats was observed. Moreover, gene expression pointed to increased risk of liver injury. One of the top upregulated genes in this tissue was Krt23, a marker of hepatic disease in humans that was also increased at the protein level.RESULTSSustained intake of an isocaloric high-fat diet had a deep impact on the liver transcriptome, mainly affecting lipid metabolism. Although serum cholesterol levels were not affected, circulating triacylglycerols were lower, and metabolic adaptations at gene expression level indicated adaptation toward handling the increased fat content of the diet, an increased triacylglycerol and cholesterol deposition in liver of MONW rats was observed. Moreover, gene expression pointed to increased risk of liver injury. One of the top upregulated genes in this tissue was Krt23, a marker of hepatic disease in humans that was also increased at the protein level.Long-term intake of a high-fat diet, even in the absence of overweight/obesity or increase in classical blood risk biomarkers, promotes a molecular environment leading to hepatic lipid accumulation and increasing the risk of suffering from hepatic diseases.CONCLUSIONLong-term intake of a high-fat diet, even in the absence of overweight/obesity or increase in classical blood risk biomarkers, promotes a molecular environment leading to hepatic lipid accumulation and increasing the risk of suffering from hepatic diseases.
International Journal of Obesity (2016) 40, 1250-1259; doi: 10.1038/ijo.2016.47
Background/Objectives: Consumption of fat-rich foods is associated with obesity and related alterations. However, there is a group of individuals, the metabolically obese normal-weight (MONW) subjects, who present normal body weight but have metabolic features characteristic of the obese status, including fat deposition in critical tissues such as liver, recognized as a major cause for the promotion of metabolic diseases. Our aim was to better understand metabolic alterations present in liver of MONW rats applying whole genome transcriptome analysis. Methods: Wistar rats were chronically fed a high-fat diet isocaloric relative to Control animals to avoid the hyperphagia and overweight and to mimic MONW features. Liver transcriptome analysis of both groups was performed. Results: Sustained intake of an isocaloric high-fat diet had a deep impact on the liver transcriptome, mainly affecting lipid metabolism. Although serum cholesterol levels were not affected, circulating triacylglycerols were lower, and metabolic adaptations at gene expression level indicated adaptation toward handling the increased fat content of the diet, an increased triacylglycerol and cholesterol deposition in liver of MONW rats was observed. Moreover, gene expression pointed to increased risk of liver injury. One of the top upregulated genes in this tissue was Krt23 , a marker of hepatic disease in humans that was also increased at the protein level. Conclusion: Long-term intake of a high-fat diet, even in the absence of overweight/obesity or increase in classical blood risk biomarkers, promotes a molecular environment leading to hepatic lipid accumulation and increasing the risk of suffering from hepatic diseases.
Audience Academic
Author Díaz-Rúa, R
Keijer, J
Palou, A
van Schothorst, E M
Oliver, P
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Cites_doi 10.1016/j.bbalip.2006.07.007
10.1016/j.numecd.2010.09.001
10.1152/ajpgi.00521.2005
10.1530/JME-11-0001
10.1124/jpet.103.061671
10.1139/h06-092
10.5812/ijhrba.8725
10.3402/fnr.v58.24114
10.1016/S0140-6736(03)15269-5
10.1161/ATVBAHA.113.301948
10.2337/diabetes.48.11.2210
10.1038/nature05488
10.1002/hep.25961
10.1017/S1368980013000463
10.1016/j.gene.2004.06.015
10.1053/beem.2002.0228
10.1016/j.metabol.2009.11.006
10.1016/j.jnutbio.2014.11.013
10.1038/oby.2011.34
10.4254/wjh.v6.i11.800
10.1007/s10863-014-9570-z
10.1016/j.steroids.2013.10.012
10.1111/cen.12181
10.3109/07853890.2011.605387
10.1016/j.jnutbio.2011.05.008
10.1210/en.2009-0934
10.1371/journal.pone.0088584
10.1002/hep.20466
10.1002/sim.4780090710
10.1194/jlr.M054544
10.1017/S0007114514003183
10.1111/j.1365-2265.2011.04085.x
10.1016/0003-2697(76)90527-3
10.1177/29.4.6166661
10.1053/jhep.2002.33200
10.1016/j.clnu.2013.10.008
10.1038/ijo.2015.112
10.1074/jbc.R114.576355
10.3350/cmh.2013.19.3.210
10.1039/C4FO00429A
10.1053/j.gastro.2010.12.006
10.1080/03602530701468573
10.1016/j.bbalip.2013.11.010
10.1038/oby.2011.142
10.1016/j.ab.2007.01.016
10.1152/ajpendo.00717.2006
10.1053/j.gastro.2011.06.040
10.1152/ajpheart.00646.2012
10.1016/j.diabres.2011.02.003
10.1371/journal.pone.0046584
10.1093/ajcn.81.2.341
10.3945/an.113.005678
10.1155/2012/374346
10.1007/BF00280883
10.2337/diabetes.47.5.699
10.1055/s-2001-12928
10.1371/journal.pone.0060853
10.3748/wjg.v20.i44.16464
10.1016/j.numecd.2013.06.003
10.1001/archinte.163.4.427
10.1155/2009/952734
10.1016/S0021-9258(18)64849-5
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PublicationSubtitle Official journal of the International Association for the Study of Obesity
PublicationTitle International Journal of Obesity
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References Browning, Szczepaniak, Dobbins, Nuremberg, Horton, Cohen (CR17) 2004; 40
Selfridge, Wilkins, E, Carl, Koppel, Funk (CR46) 2014; 47
Yajnik, Yudkin (CR6) 2004; 363
Hardwick, Osei-Hyiaman, Wiland, Abdelmegeed, Song (CR44) 2009; 2009
Folch, Lees, Sloane Stanley (CR27) 1957; 226
Kennedy, Pissios, Otu, Roberson, Xue, Asakura (CR40) 2007; 292
Arsenault, Beaumont, Despres, Larose (CR15) 2012; 44
Yoon, Cha (CR38) 2014; 6
Koo (CR18) 2013; 19
Adamsson, Cederholm, Vessby, Riserus (CR58) 2014; 58
Diethelm, Huybrechts, Moreno, De Henauw, Manios, Beghin (CR2) 2014; 17
Molero-Conejo, Morales, Fernandez, Raleigh, Gomez, Semprun-Fereira (CR10) 2003; 53
Diaz-Rua, Garcia-Ruiz, Caimari, Palou, Oliver (CR23) 2014; 5
Otero, Stafford, McGuinness (CR37) 2014; 289
Caterson, Gill (CR5) 2002; 16
Despres, Lemieux (CR16) 2006; 444
Quiroga, Li, Trotzmuller, Nelson, Proctor, Kofeler (CR52) 2012; 56
Robichon, Varret, Le Liepvre, Lasnier, Hajduch, Ferre (CR50) 2006; 1761
VerHague, Cheng, Weinberg, Shelness (CR49) 2013; 33
Lee, Ha, Park, Lee, Yim, Yoon (CR7) 2011; 75
Wang, Mitsche, Luetjohann, Cohen, Xie, Hobbs (CR60) 2014; 56
Rees, Dyakova, Wilson, Ward, Thorogood, Brunner (CR56) 2013; 12
Van Rooyen, Larter, Haigh, Yeh, Ioannou, Kuver (CR61) 2011; 141
de Meijer, Le, Meisel, Akhavan Sharif, Pan, Nose (CR55) 2010; 59
Rao, Reddy (CR41) 2001; 21
Labayen, Ruiz, Ortega, Huybrechts, Rodriguez, Jimenez-Pavon (CR4) 2013; 33
Ruderman, Chisholm, Pi-Sunyer, Schneider (CR9) 1998; 47
Hochberg, Benjamini (CR33) 1990; 9
Abdel-Hamid, Nazmy, Abdel-Bakey (CR47) 2011; 92
Matthews, Hosker, Rudenski, Naylor, Treacher, Turner (CR24) 1985; 28
Seifter, Dayton, Novic, Muntwyler (CR26) 1950; 25
Diaz-Rua, Keijer, Caimari, van Schothorst, Palou, Oliver (CR32) 2015; 26
Bel-Serrat, Mouratidou, Huybrechts, Labayen, Cuenca-Garcia, Palacios (CR3) 2014; 112
Cordain, Eaton, Sebastian, Mann, Lindeberg, Watkins (CR36) 2005; 81
Yang, Xu, Guo, Ning, Zhi, Yin (CR64) 2013; 8
Thomas, Parkinson, Frost, Goldstone, Dore, McCarthy (CR14) 2012; 20
Starmann, Falth, Spindelbock, Lanz, Lackner, Zatloukal (CR35) 2012; 7
Hsu, Raine, Fanger (CR34) 1981; 29
Reddy, Rao (CR43) 2006; 290
Renaud, Cui, Lu, Klaassen (CR48) 2014; 9
Hsu, Savas, Griffin, Johnson (CR42) 2007; 39
Conus, Rabasa-Lhoret, Peronnet (CR13) 2007; 32
van Schothorst, Pagmantidis, de Boer, Hesketh, Keijer (CR30) 2007; 363
Kim, Sohn, Ahn, Lee, Lee, Lee (CR39) 2004; 340
Caimari, Oliver, Palou (CR25) 2012; 23
Duivenvoorde, van Schothorst, Bunschoten, Keijer (CR31) 2011; 47
Rossmeisl, Medrikova, van Schothorst, Pavlisova, Kuda, Hensler (CR59) 2014; 1841
Rahati, Shahraki, Arjomand, Shahraki (CR21) 2014; 3
Kim, Kim, Chung, Jeong, Lee, Kim (CR65) 2012; 20
Moreno, Gottrand, Huybrechts, Ruiz, Gonzalez-Gross, DeHenauw (CR1) 2014; 5
Pandak, Hylemon, Ren, Marques, Gil, Redford (CR51) 2002; 35
Garcia-Ruiz, Reynes, Diaz-Rua, Ceresi, Oliver, Palou (CR29) 2015; 39
Choi, Se-Young, Lee, Tak, Hong, Park (CR19) 2012; 22
Calvisi, Wang, Ho, Ladu, Lee, Mattu (CR63) 2011; 140
Cao, Liu, Cao, Lv, Tong (CR20) 2012; 2012
Cotter, Schugar, Crawford (CR45) 2013; 304
Lopez-Miranda, Perez-Martinez (CR8) 2013; 79
Palou, Priego, Sanchez, Torrens, Palou, Pico (CR22) 2010; 151
Park, Zhu, Palaniappan, Heshka, Carnethon, Heymsfield (CR12) 2003; 163
Jiang, Pu, Hou, Chen, Alanazy, Hebbard (CR62) 2014; 20
Dvorak, DeNino, Ades, Poehlman (CR11) 1999; 48
Bradford (CR28) 1976; 72
Matsubara, Kim, Miyata, Shimada, Nagata, Yamazoe (CR53) 2004; 309
Rizner, Penning (CR54) 2014; 79
Garshick, Mochari-Greenberger, Mosca (CR57) 2014; 24
E Molero-Conejo (BFijo201647_CR10) 2003; 53
DM Van Rooyen (BFijo201647_CR61) 2011; 141
LP Duivenvoorde (BFijo201647_CR31) 2011; 47
CM Jiang (BFijo201647_CR62) 2014; 20
N Ruderman (BFijo201647_CR9) 1998; 47
JK Reddy (BFijo201647_CR43) 2006; 290
NM Abdel-Hamid (BFijo201647_CR47) 2011; 92
CS Yajnik (BFijo201647_CR6) 2004; 363
J Lopez-Miranda (BFijo201647_CR8) 2013; 79
S Kim (BFijo201647_CR39) 2004; 340
MA VerHague (BFijo201647_CR49) 2013; 33
R Diaz-Rua (BFijo201647_CR23) 2014; 5
JE Selfridge (BFijo201647_CR46) 2014; 47
K Rees (BFijo201647_CR56) 2013; 12
X Yang (BFijo201647_CR64) 2013; 8
Y Hochberg (BFijo201647_CR33) 1990; 9
AD Quiroga (BFijo201647_CR52) 2012; 56
MH Hsu (BFijo201647_CR42) 2007; 39
R Diaz-Rua (BFijo201647_CR32) 2015; 26
LA Moreno (BFijo201647_CR1) 2014; 5
JP Despres (BFijo201647_CR16) 2006; 444
SH Koo (BFijo201647_CR18) 2013; 19
S Rahati (BFijo201647_CR21) 2014; 3
E Garcia-Ruiz (BFijo201647_CR29) 2015; 39
A Caimari (BFijo201647_CR25) 2012; 23
M Garshick (BFijo201647_CR57) 2014; 24
T Matsubara (BFijo201647_CR53) 2004; 309
EM van Schothorst (BFijo201647_CR30) 2007; 363
J Folch (BFijo201647_CR27) 1957; 226
L Cordain (BFijo201647_CR36) 2005; 81
K Diethelm (BFijo201647_CR2) 2014; 17
MM Bradford (BFijo201647_CR28) 1976; 72
J Choi (BFijo201647_CR19) 2012; 22
DR Matthews (BFijo201647_CR24) 1985; 28
YF Otero (BFijo201647_CR37) 2014; 289
C Robichon (BFijo201647_CR50) 2006; 1761
WM Pandak (BFijo201647_CR51) 2002; 35
I Labayen (BFijo201647_CR4) 2013; 33
RV Dvorak (BFijo201647_CR11) 1999; 48
M Rossmeisl (BFijo201647_CR59) 2014; 1841
J Starmann (BFijo201647_CR35) 2012; 7
VE de Meijer (BFijo201647_CR55) 2010; 59
J Wang (BFijo201647_CR60) 2014; 56
MC Kim (BFijo201647_CR65) 2012; 20
ID Caterson (BFijo201647_CR5) 2002; 16
TL Rizner (BFijo201647_CR54) 2014; 79
DG Cotter (BFijo201647_CR45) 2013; 304
F Conus (BFijo201647_CR13) 2007; 32
JD Browning (BFijo201647_CR17) 2004; 40
DF Calvisi (BFijo201647_CR63) 2011; 140
S Bel-Serrat (BFijo201647_CR3) 2014; 112
JP Hardwick (BFijo201647_CR44) 2009; 2009
EL Thomas (BFijo201647_CR14) 2012; 20
MS Rao (BFijo201647_CR41) 2001; 21
HJ Yoon (BFijo201647_CR38) 2014; 6
YW Park (BFijo201647_CR12) 2003; 163
BJ Arsenault (BFijo201647_CR15) 2012; 44
M Palou (BFijo201647_CR22) 2010; 151
SM Hsu (BFijo201647_CR34) 1981; 29
S Seifter (BFijo201647_CR26) 1950; 25
HJ Renaud (BFijo201647_CR48) 2014; 9
V Adamsson (BFijo201647_CR58) 2014; 58
L Cao (BFijo201647_CR20) 2012; 2012
AR Kennedy (BFijo201647_CR40) 2007; 292
SH Lee (BFijo201647_CR7) 2011; 75
25378657 - J Lipid Res. 2015 Feb;56(2):319-30
24133660 - Clin Mol Hepatol. 2013 Sep;19(3):210-5
21147110 - Gastroenterology. 2011 Mar;140(3):1071-83
25469014 - World J Gastroenterol. 2014 Nov 28;20(44):16464-73
21186103 - Nutr Metab Cardiovasc Dis. 2012 Jul;22(7):567-74
25266916 - Food Funct. 2014 Dec;5(12):3117-31
23396451 - Am J Physiol Heart Circ Physiol. 2013 Apr 15;304(8):H1060-76
20068006 - Endocrinology. 2010 Mar;151(3):1030-41
15699220 - Am J Clin Nutr. 2005 Feb;81(2):341-54
6166661 - J Histochem Cytochem. 1981 Apr;29(4):577-80
2218183 - Stat Med. 1990 Jul;9(7):811-8
12029625 - Hepatology. 2002 Jun;35(6):1400-8
23593328 - PLoS One. 2013 Apr 11;8(4):e60853
24189185 - Steroids. 2014 Jan;79:49-63
21521351 - Clin Endocrinol (Oxf). 2011 Oct;75(4):475-81
21660078 - Obesity (Silver Spring). 2012 Jan;20(1):76-87
20300478 - PPAR Res. 2009;2009:952734
26063331 - Int J Obes (Lond). 2015 Nov;39(11):1619-29
23445212 - Clin Endocrinol (Oxf). 2013 Sep;79(3):314-5
15401229 - Arch Biochem. 1950 Jan;25(1):191-200
16950652 - Biochim Biophys Acta. 2006 Sep;1761(9):1107-13
25469407 - Adv Nutr. 2014 Sep;5(5):615S-623S
24907277 - J Biol Chem. 2014 Jul 25;289(30):20462-9
24295779 - Biochim Biophys Acta. 2014 Feb;1841(2):267-78
16603729 - Am J Physiol Gastrointest Liver Physiol. 2006 May;290(5):G852-8
12942870 - Arch Latinoam Nutr. 2003 Mar;53(1):39-46
17320029 - Anal Biochem. 2007 Apr 15;363(2):315-7
24971303 - Int J High Risk Behav Addict. 2014 Mar 10;3(1):e8725
3899825 - Diabetologia. 1985 Jul;28(7):412-9
13428781 - J Biol Chem. 1957 May;226(1):497-509
22806626 - Hepatology. 2012 Dec;56(6):2188-98
21703998 - Gastroenterology. 2011 Oct;141(4):1393-403, 1403.e1-5
17299079 - Am J Physiol Endocrinol Metab. 2007 Jun;292(6):E1724-39
10535456 - Diabetes. 1999 Nov;48(11):2210-4
24030551 - Arterioscler Thromb Vasc Biol. 2013 Nov;33(11):2501-8
21610007 - J Mol Endocrinol. 2011 Aug 03;47(1):81-97
21388699 - Diabetes Res Clin Pract. 2011 May;92(2):228-37
15556298 - Gene. 2004 Sep 29;340(1):99-109
24551121 - PLoS One. 2014 Feb 14;9(2):e88584
25366323 - Br J Nutr. 2014 Dec 28;112(12 ):2049-59
23472739 - Public Health Nutr. 2014 Mar;17 (3):486-97
25660595 - J Nutr Biochem. 2015 Apr;26(4):398-407
15565570 - Hepatology. 2004 Dec;40(6):1387-95
25104046 - J Bioenerg Biomembr. 2015 Apr;47(1-2):1-11
21372806 - Obesity (Silver Spring). 2012 Sep;20(9):1876-81
25476792 - Food Nutr Res. 2014 Dec 03;58:24114
9588440 - Diabetes. 1998 May;47(5):699-713
942051 - Anal Biochem. 1976 May 7;72:248-54
21944063 - J Nutr Biochem. 2012 Sep;23(9):1041-50
11296696 - Semin Liver Dis. 2001;21(1):43-55
23071592 - PLoS One. 2012;7(10):e46584
17786636 - Drug Metab Rev. 2007;39(2-3):515-38
23320128 - Oxid Med Cell Longev. 2012;2012:374346
20060143 - Metabolism. 2010 Aug;59(8):1092-105
14726172 - Lancet. 2004 Jan 10;363(9403):163
25429318 - World J Hepatol. 2014 Nov 27;6(11):800-11
17332780 - Appl Physiol Nutr Metab. 2007 Feb;32(1):4-12
22149719 - Ann Med. 2012 Dec;44(8):758-72
24099723 - Nutr Metab Cardiovasc Dis. 2014 Jan;24(1):100-6
17167477 - Nature. 2006 Dec 14;444(7121):881-7
15004215 - J Pharmacol Exp Ther. 2004 Jun;309(3):1282-90
24182766 - Clin Nutr. 2014 Oct;33(5):859-66
12468409 - Best Pract Res Clin Endocrinol Metab. 2002 Dec;16(4):595-610
24318424 - Cochrane Database Syst Rev. 2013 Dec 06;(12):CD002128
12588201 - Arch Intern Med. 2003 Feb 24;163(4):427-36
References_xml – volume: 1761
  start-page: 1107
  year: 2006
  end-page: 1113
  ident: CR50
  article-title: DnaJA4 is a SREBP-regulated chaperone involved in the cholesterol biosynthesis pathway
  publication-title: Biochim Biophys Acta
  doi: 10.1016/j.bbalip.2006.07.007
– volume: 22
  start-page: 567
  year: 2012
  end-page: 574
  ident: CR19
  article-title: Characteristics of diet patterns in metabolically obese, normal weight adults (Korean National Health and Nutrition Examination Survey III, 2005)
  publication-title: Nutr Metab Cardiovasc Dis
  doi: 10.1016/j.numecd.2010.09.001
– volume: 290
  start-page: G852
  year: 2006
  end-page: G858
  ident: CR43
  article-title: Lipid metabolism and liver inflammation. II. Fatty liver disease and fatty acid oxidation
  publication-title: Am J Physiol Gastrointest Liver Physiol
  doi: 10.1152/ajpgi.00521.2005
– volume: 47
  start-page: 81
  year: 2011
  end-page: 97
  ident: CR31
  article-title: Dietary restriction of mice on a high-fat diet induces substrate efficiency and improves metabolic health
  publication-title: J Mol Endocrinol
  doi: 10.1530/JME-11-0001
– volume: 309
  start-page: 1282
  year: 2004
  end-page: 1290
  ident: CR53
  article-title: Isolation and characterization of a new major intestinal CYP3A form, CYP3A62, in the rat
  publication-title: J Pharmacol Exp Ther
  doi: 10.1124/jpet.103.061671
– volume: 32
  start-page: 4
  year: 2007
  end-page: 12
  ident: CR13
  article-title: Characteristics of metabolically obese normal-weight (MONW) subjects
  publication-title: Appl Physiol Nutr Metab
  doi: 10.1139/h06-092
– volume: 3
  start-page: e8725
  year: 2014
  ident: CR21
  article-title: Food pattern, lifestyle and diabetes mellitus
  publication-title: Int J High Risk Behav Addict
  doi: 10.5812/ijhrba.8725
– volume: 58
  start-page: 24114
  year: 2014
  ident: CR58
  article-title: Influence of a healthy Nordic diet on serum fatty acid composition and associations with blood lipoproteins - results from the NORDIET study
  publication-title: Food Nutr Res
  doi: 10.3402/fnr.v58.24114
– volume: 363
  start-page: 163
  year: 2004
  ident: CR6
  article-title: The Y-Y paradox
  publication-title: Lancet
  doi: 10.1016/S0140-6736(03)15269-5
– volume: 226
  start-page: 497
  year: 1957
  end-page: 509
  ident: CR27
  article-title: A simple method for the isolation and purification of total lipides from animal tissues
  publication-title: J Biol Chem
– volume: 33
  start-page: 2501
  year: 2013
  end-page: 2508
  ident: CR49
  article-title: Apolipoprotein A-IV expression in mouse liver enhances triglyceride secretion and reduces hepatic lipid content by promoting very low density lipoprotein particle expansion
  publication-title: Arterioscler Thromb Vasc Biol
  doi: 10.1161/ATVBAHA.113.301948
– volume: 48
  start-page: 2210
  year: 1999
  end-page: 2214
  ident: CR11
  article-title: Phenotypic characteristics associated with insulin resistance in metabolically obese but normal-weight young women
  publication-title: Diabetes
  doi: 10.2337/diabetes.48.11.2210
– volume: 444
  start-page: 881
  year: 2006
  end-page: 887
  ident: CR16
  article-title: Abdominal obesity and metabolic syndrome
  publication-title: Nature
  doi: 10.1038/nature05488
– volume: 56
  start-page: 2188
  year: 2012
  end-page: 2198
  ident: CR52
  article-title: Deficiency of carboxylesterase 1/esterase-x results in obesity, hepatic steatosis, and hyperlipidemia
  publication-title: Hepatology
  doi: 10.1002/hep.25961
– volume: 17
  start-page: 486
  year: 2014
  end-page: 497
  ident: CR2
  article-title: Nutrient intake of European adolescents: results of the HELENA (Healthy Lifestyle in Europe by Nutrition in Adolescence) Study
  publication-title: Public Health Nutr
  doi: 10.1017/S1368980013000463
– volume: 340
  start-page: 99
  year: 2004
  end-page: 109
  ident: CR39
  article-title: Hepatic gene expression profiles in a long-term high-fat diet-induced obesity mouse model
  publication-title: Gene
  doi: 10.1016/j.gene.2004.06.015
– volume: 16
  start-page: 595
  year: 2002
  end-page: 610
  ident: CR5
  article-title: Obesity: epidemiology and possible prevention
  publication-title: Best Pract Res Clin Endocrinol Metab
  doi: 10.1053/beem.2002.0228
– volume: 59
  start-page: 1092
  year: 2010
  end-page: 1105
  ident: CR55
  article-title: Dietary fat intake promotes the development of hepatic steatosis independently from excess caloric consumption in a murine model
  publication-title: Metabolism
  doi: 10.1016/j.metabol.2009.11.006
– volume: 26
  start-page: 398
  year: 2015
  end-page: 407
  ident: CR32
  article-title: Peripheral blood mononuclear cells as a source to detect markers of homeostatic alterations caused by the intake of diets with an unbalanced macronutrient composition
  publication-title: J Nutr Biochem
  doi: 10.1016/j.jnutbio.2014.11.013
– volume: 20
  start-page: 1876
  year: 2012
  end-page: 1881
  ident: CR65
  article-title: MONW phenotype is associated with advanced colorectal adenoma in Korean men
  publication-title: Obesity (Silver Spring)
  doi: 10.1038/oby.2011.34
– volume: 6
  start-page: 800
  year: 2014
  end-page: 811
  ident: CR38
  article-title: Pathogenesis and therapeutic approaches for non-alcoholic fatty liver disease
  publication-title: World J Hepatol
  doi: 10.4254/wjh.v6.i11.800
– volume: 47
  start-page: 1
  year: 2014
  end-page: 11
  ident: CR46
  article-title: Effect of one month duration ketogenic and non-ketogenic high fat diets on mouse brain bioenergetic infrastructure
  publication-title: J Bioenerg Biomembr
  doi: 10.1007/s10863-014-9570-z
– volume: 79
  start-page: 49
  year: 2014
  end-page: 63
  ident: CR54
  article-title: Role of aldo-keto reductase family 1 (AKR1) enzymes in human steroid metabolism
  publication-title: Steroids
  doi: 10.1016/j.steroids.2013.10.012
– volume: 79
  start-page: 314
  year: 2013
  end-page: 315
  ident: CR8
  article-title: It is time to define metabolically obese but normal-weight (MONW) individuals
  publication-title: Clin Endocrinol
  doi: 10.1111/cen.12181
– volume: 12
  start-page: CD002128
  year: 2013
  ident: CR56
  article-title: Dietary advice for reducing cardiovascular risk
  publication-title: Cochrane Database Syst Rev
– volume: 44
  start-page: 758
  year: 2012
  end-page: 772
  ident: CR15
  article-title: Mapping body fat distribution: a key step towards the identification of the vulnerable patient?
  publication-title: Ann Med
  doi: 10.3109/07853890.2011.605387
– volume: 23
  start-page: 1041
  year: 2012
  end-page: 1050
  ident: CR25
  article-title: Adipose triglyceride lipase expression and fasting regulation are differently affected by cold exposure in adipose tissues of lean and obese Zucker rats
  publication-title: J Nutr Biochem
  doi: 10.1016/j.jnutbio.2011.05.008
– volume: 151
  start-page: 1030
  year: 2010
  end-page: 1041
  ident: CR22
  article-title: Moderate caloric restriction in lactating rats protects offspring against obesity and insulin resistance in later life
  publication-title: Endocrinology
  doi: 10.1210/en.2009-0934
– volume: 9
  start-page: e88584
  year: 2014
  ident: CR48
  article-title: Effect of diet on expression of genes involved in lipid metabolism, oxidative stress, and inflammation in mouse liver-insights into mechanisms of hepatic steatosis
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0088584
– volume: 40
  start-page: 1387
  year: 2004
  end-page: 1395
  ident: CR17
  article-title: Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity
  publication-title: Hepatology
  doi: 10.1002/hep.20466
– volume: 9
  start-page: 811
  year: 1990
  end-page: 818
  ident: CR33
  article-title: More powerful procedures for multiple significance testing
  publication-title: Stat Med
  doi: 10.1002/sim.4780090710
– volume: 56
  start-page: 319
  year: 2014
  end-page: 330
  ident: CR60
  article-title: Relative roles of ABCG5/ABCG8 in liver and intestine
  publication-title: J Lipid Res
  doi: 10.1194/jlr.M054544
– volume: 112
  start-page: 2049
  year: 2014
  end-page: 2059
  ident: CR3
  article-title: Associations between macronutrient intake and serum lipid profile depend on body fat in European adolescents: the Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) study
  publication-title: Br J Nutr
  doi: 10.1017/S0007114514003183
– volume: 75
  start-page: 475
  year: 2011
  end-page: 481
  ident: CR7
  article-title: Identifying metabolically obese but normal-weight (MONW) individuals in a nondiabetic Korean population: the Chungju Metabolic disease Cohort (CMC) study
  publication-title: Clin Endocrinol (Oxf)
  doi: 10.1111/j.1365-2265.2011.04085.x
– volume: 72
  start-page: 248
  year: 1976
  end-page: 254
  ident: CR28
  article-title: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
  publication-title: Anal Biochem
  doi: 10.1016/0003-2697(76)90527-3
– volume: 29
  start-page: 577
  year: 1981
  end-page: 580
  ident: CR34
  article-title: Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures
  publication-title: J Histochem Cytochem
  doi: 10.1177/29.4.6166661
– volume: 35
  start-page: 1400
  year: 2002
  end-page: 1408
  ident: CR51
  article-title: Regulation of oxysterol 7alpha-hydroxylase (CYP7B1) in primary cultures of rat hepatocytes
  publication-title: Hepatology
  doi: 10.1053/jhep.2002.33200
– volume: 33
  start-page: 859
  year: 2013
  end-page: 866
  ident: CR4
  article-title: High fat diets are associated with higher abdominal adiposity regardless of physical activity in adolescents; the HELENA study
  publication-title: Clin Nutr
  doi: 10.1016/j.clnu.2013.10.008
– volume: 25
  start-page: 191
  year: 1950
  end-page: 200
  ident: CR26
  article-title: The estimation of glycogen with the anthrone reagent
  publication-title: Arch Biochem
– volume: 39
  start-page: 1619
  year: 2015
  end-page: 1629
  ident: CR29
  article-title: The intake of high-fat diets induces the acquisition of brown adipocyte gene expression features in white adipose tissue
  publication-title: Int J Obes (Lond)
  doi: 10.1038/ijo.2015.112
– volume: 289
  start-page: 20462
  year: 2014
  end-page: 20469
  ident: CR37
  article-title: Pathway-selective insulin resistance and metabolic disease: the importance of nutrient flux
  publication-title: J Biol Chem
  doi: 10.1074/jbc.R114.576355
– volume: 19
  start-page: 210
  year: 2013
  end-page: 215
  ident: CR18
  article-title: Nonalcoholic fatty liver disease: molecular mechanisms for the hepatic steatosis
  publication-title: Clin Mol Hepatol
  doi: 10.3350/cmh.2013.19.3.210
– volume: 5
  start-page: 3117
  year: 2014
  end-page: 3131
  ident: CR23
  article-title: Sustained exposure to diets with an unbalanced macronutrient proportion alters key genes involved in energy homeostasis and obesity-related metabolic parameters in rats
  publication-title: Food Funct
  doi: 10.1039/C4FO00429A
– volume: 140
  start-page: 1071
  year: 2011
  end-page: 1083
  ident: CR63
  article-title: Increased lipogenesis, induced by AKT-mTORC1-RPS6 signaling, promotes development of human hepatocellular carcinoma
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2010.12.006
– volume: 39
  start-page: 515
  year: 2007
  end-page: 538
  ident: CR42
  article-title: Human cytochrome p450 family 4 enzymes: function, genetic variation and regulation
  publication-title: Drug Metab Rev
  doi: 10.1080/03602530701468573
– volume: 1841
  start-page: 267
  year: 2014
  end-page: 278
  ident: CR59
  article-title: Omega-3 phospholipids from fish suppress hepatic steatosis by integrated inhibition of biosynthetic pathways in dietary obese mice
  publication-title: Biochim Biophys Acta
  doi: 10.1016/j.bbalip.2013.11.010
– volume: 20
  start-page: 76
  year: 2012
  end-page: 87
  ident: CR14
  article-title: The missing risk: MRI and MRS phenotyping of abdominal adiposity and ectopic fat
  publication-title: Obesity
  doi: 10.1038/oby.2011.142
– volume: 363
  start-page: 315
  year: 2007
  end-page: 317
  ident: CR30
  article-title: Assessment of reducing RNA input for Agilent oligo microarrays
  publication-title: Anal Biochem
  doi: 10.1016/j.ab.2007.01.016
– volume: 292
  start-page: E1724
  year: 2007
  end-page: E1739
  ident: CR40
  article-title: A high-fat, ketogenic diet induces a unique metabolic state in mice
  publication-title: Am J Physiol Endocrinol Metab
  doi: 10.1152/ajpendo.00717.2006
– volume: 141
  start-page: 1403 e1
  year: 2011
  end-page: 1403 e5
  ident: CR61
  article-title: Hepatic free cholesterol accumulates in obese, diabetic mice and causes nonalcoholic steatohepatitis
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2011.06.040
– volume: 304
  start-page: H1060
  year: 2013
  end-page: H1076
  ident: CR45
  article-title: Ketone body metabolism and cardiovascular disease
  publication-title: Am J Physiol Heart Circ Physiol
  doi: 10.1152/ajpheart.00646.2012
– volume: 92
  start-page: 228
  year: 2011
  end-page: 237
  ident: CR47
  article-title: Polyol profile as an early diagnostic and prognostic marker in natural product chemoprevention of hepatocellular carcinoma in diabetic rats
  publication-title: Diabetes Res Clin Pract
  doi: 10.1016/j.diabres.2011.02.003
– volume: 7
  start-page: e46584
  year: 2012
  ident: CR35
  article-title: Gene expression profiling unravels cancer-related hepatic molecular signatures in steatohepatitis but not in steatosis
  publication-title: PloS One
  doi: 10.1371/journal.pone.0046584
– volume: 81
  start-page: 341
  year: 2005
  end-page: 354
  ident: CR36
  article-title: Origins and evolution of the Western diet: health implications for the 21st century
  publication-title: Am J Clin Nutr
  doi: 10.1093/ajcn.81.2.341
– volume: 5
  start-page: 615S
  year: 2014
  end-page: 623S
  ident: CR1
  article-title: Nutrition and lifestyle in european adolescents: the HELENA (Healthy Lifestyle in Europe by Nutrition in Adolescence) study
  publication-title: Adv Nutr
  doi: 10.3945/an.113.005678
– volume: 2012
  start-page: 374346
  year: 2012
  ident: CR20
  article-title: Modified high-sucrose diet-induced abdominally obese and normal-weight rats developed high plasma free fatty acid and insulin resistance
  publication-title: Oxid Med Cell Longev
  doi: 10.1155/2012/374346
– volume: 28
  start-page: 412
  year: 1985
  end-page: 419
  ident: CR24
  article-title: Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man
  publication-title: Diabetologia
  doi: 10.1007/BF00280883
– volume: 47
  start-page: 699
  year: 1998
  end-page: 713
  ident: CR9
  article-title: The metabolically obese, normal-weight individual revisited
  publication-title: Diabetes
  doi: 10.2337/diabetes.47.5.699
– volume: 53
  start-page: 39
  year: 2003
  end-page: 46
  ident: CR10
  article-title: Lean adolescents with increased risk for metabolic syndrome
  publication-title: Arch Latinoam Nutr
– volume: 21
  start-page: 43
  year: 2001
  end-page: 55
  ident: CR41
  article-title: Peroxisomal beta-oxidation and steatohepatitis
  publication-title: Semin Liver Dis
  doi: 10.1055/s-2001-12928
– volume: 8
  start-page: e60853
  year: 2013
  ident: CR64
  article-title: Hydroxysteroid sulfotransferase SULT2B1b promotes hepatocellular carcinoma cells proliferation and
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0060853
– volume: 2009
  start-page: 952734
  year: 2009
  ident: CR44
  article-title: PPAR/RXR regulation of fatty acid metabolism and fatty acid omega-hydroxylase (CYP4) isozymes: implications for prevention of lipotoxicity in fatty liver disease
  publication-title: PPAR Res
– volume: 20
  start-page: 16464
  year: 2014
  end-page: 16473
  ident: CR62
  article-title: Non alcoholic steatohepatitis a precursor for hepatocellular carcinoma development
  publication-title: World J Gastroenterol
  doi: 10.3748/wjg.v20.i44.16464
– volume: 24
  start-page: 100
  year: 2014
  end-page: 106
  ident: CR57
  article-title: Reduction in dietary trans fat intake is associated with decreased LDL particle number in a primary prevention population
  publication-title: Nutr Metab Cardiovasc Dis
  doi: 10.1016/j.numecd.2013.06.003
– volume: 163
  start-page: 427
  year: 2003
  end-page: 436
  ident: CR12
  article-title: The metabolic syndrome: prevalence and associated risk factor findings in the US population from the Third National Health and Nutrition Examination Survey, 1988-1994
  publication-title: Arch Intern Med
  doi: 10.1001/archinte.163.4.427
– volume: 7
  start-page: e46584
  year: 2012
  ident: BFijo201647_CR35
  publication-title: PloS One
  doi: 10.1371/journal.pone.0046584
– volume: 12
  start-page: CD002128
  year: 2013
  ident: BFijo201647_CR56
  publication-title: Cochrane Database Syst Rev
– volume: 21
  start-page: 43
  year: 2001
  ident: BFijo201647_CR41
  publication-title: Semin Liver Dis
  doi: 10.1055/s-2001-12928
– volume: 140
  start-page: 1071
  year: 2011
  ident: BFijo201647_CR63
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2010.12.006
– volume: 9
  start-page: 811
  year: 1990
  ident: BFijo201647_CR33
  publication-title: Stat Med
  doi: 10.1002/sim.4780090710
– volume: 9
  start-page: e88584
  year: 2014
  ident: BFijo201647_CR48
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0088584
– volume: 1761
  start-page: 1107
  year: 2006
  ident: BFijo201647_CR50
  publication-title: Biochim Biophys Acta
  doi: 10.1016/j.bbalip.2006.07.007
– volume: 24
  start-page: 100
  year: 2014
  ident: BFijo201647_CR57
  publication-title: Nutr Metab Cardiovasc Dis
  doi: 10.1016/j.numecd.2013.06.003
– volume: 32
  start-page: 4
  year: 2007
  ident: BFijo201647_CR13
  publication-title: Appl Physiol Nutr Metab
  doi: 10.1139/h06-092
– volume: 39
  start-page: 1619
  year: 2015
  ident: BFijo201647_CR29
  publication-title: Int J Obes (Lond)
  doi: 10.1038/ijo.2015.112
– volume: 39
  start-page: 515
  year: 2007
  ident: BFijo201647_CR42
  publication-title: Drug Metab Rev
  doi: 10.1080/03602530701468573
– volume: 17
  start-page: 486
  year: 2014
  ident: BFijo201647_CR2
  publication-title: Public Health Nutr
  doi: 10.1017/S1368980013000463
– volume: 19
  start-page: 210
  year: 2013
  ident: BFijo201647_CR18
  publication-title: Clin Mol Hepatol
  doi: 10.3350/cmh.2013.19.3.210
– volume: 22
  start-page: 567
  year: 2012
  ident: BFijo201647_CR19
  publication-title: Nutr Metab Cardiovasc Dis
  doi: 10.1016/j.numecd.2010.09.001
– volume: 444
  start-page: 881
  year: 2006
  ident: BFijo201647_CR16
  publication-title: Nature
  doi: 10.1038/nature05488
– volume: 363
  start-page: 163
  year: 2004
  ident: BFijo201647_CR6
  publication-title: Lancet
  doi: 10.1016/S0140-6736(03)15269-5
– volume: 23
  start-page: 1041
  year: 2012
  ident: BFijo201647_CR25
  publication-title: J Nutr Biochem
  doi: 10.1016/j.jnutbio.2011.05.008
– volume: 79
  start-page: 314
  year: 2013
  ident: BFijo201647_CR8
  publication-title: Clin Endocrinol
  doi: 10.1111/cen.12181
– volume: 16
  start-page: 595
  year: 2002
  ident: BFijo201647_CR5
  publication-title: Best Pract Res Clin Endocrinol Metab
  doi: 10.1053/beem.2002.0228
– volume: 20
  start-page: 16464
  year: 2014
  ident: BFijo201647_CR62
  publication-title: World J Gastroenterol
  doi: 10.3748/wjg.v20.i44.16464
– volume: 5
  start-page: 3117
  year: 2014
  ident: BFijo201647_CR23
  publication-title: Food Funct
  doi: 10.1039/C4FO00429A
– volume: 3
  start-page: e8725
  year: 2014
  ident: BFijo201647_CR21
  publication-title: Int J High Risk Behav Addict
  doi: 10.5812/ijhrba.8725
– volume: 29
  start-page: 577
  year: 1981
  ident: BFijo201647_CR34
  publication-title: J Histochem Cytochem
  doi: 10.1177/29.4.6166661
– volume: 20
  start-page: 76
  year: 2012
  ident: BFijo201647_CR14
  publication-title: Obesity
  doi: 10.1038/oby.2011.142
– volume: 112
  start-page: 2049
  year: 2014
  ident: BFijo201647_CR3
  publication-title: Br J Nutr
  doi: 10.1017/S0007114514003183
– volume: 35
  start-page: 1400
  year: 2002
  ident: BFijo201647_CR51
  publication-title: Hepatology
  doi: 10.1053/jhep.2002.33200
– volume: 58
  start-page: 24114
  year: 2014
  ident: BFijo201647_CR58
  publication-title: Food Nutr Res
  doi: 10.3402/fnr.v58.24114
– volume: 2009
  start-page: 952734
  year: 2009
  ident: BFijo201647_CR44
  publication-title: PPAR Res
  doi: 10.1155/2009/952734
– volume: 304
  start-page: H1060
  year: 2013
  ident: BFijo201647_CR45
  publication-title: Am J Physiol Heart Circ Physiol
  doi: 10.1152/ajpheart.00646.2012
– volume: 92
  start-page: 228
  year: 2011
  ident: BFijo201647_CR47
  publication-title: Diabetes Res Clin Pract
  doi: 10.1016/j.diabres.2011.02.003
– volume: 309
  start-page: 1282
  year: 2004
  ident: BFijo201647_CR53
  publication-title: J Pharmacol Exp Ther
  doi: 10.1124/jpet.103.061671
– volume: 226
  start-page: 497
  year: 1957
  ident: BFijo201647_CR27
  publication-title: J Biol Chem
  doi: 10.1016/S0021-9258(18)64849-5
– volume: 72
  start-page: 248
  year: 1976
  ident: BFijo201647_CR28
  publication-title: Anal Biochem
  doi: 10.1016/0003-2697(76)90527-3
– volume: 44
  start-page: 758
  year: 2012
  ident: BFijo201647_CR15
  publication-title: Ann Med
  doi: 10.3109/07853890.2011.605387
– volume: 363
  start-page: 315
  year: 2007
  ident: BFijo201647_CR30
  publication-title: Anal Biochem
  doi: 10.1016/j.ab.2007.01.016
– volume: 47
  start-page: 1
  year: 2014
  ident: BFijo201647_CR46
  publication-title: J Bioenerg Biomembr
  doi: 10.1007/s10863-014-9570-z
– volume: 48
  start-page: 2210
  year: 1999
  ident: BFijo201647_CR11
  publication-title: Diabetes
  doi: 10.2337/diabetes.48.11.2210
– volume: 1841
  start-page: 267
  year: 2014
  ident: BFijo201647_CR59
  publication-title: Biochim Biophys Acta
  doi: 10.1016/j.bbalip.2013.11.010
– volume: 81
  start-page: 341
  year: 2005
  ident: BFijo201647_CR36
  publication-title: Am J Clin Nutr
  doi: 10.1093/ajcn.81.2.341
– volume: 340
  start-page: 99
  year: 2004
  ident: BFijo201647_CR39
  publication-title: Gene
  doi: 10.1016/j.gene.2004.06.015
– volume: 163
  start-page: 427
  year: 2003
  ident: BFijo201647_CR12
  publication-title: Arch Intern Med
  doi: 10.1001/archinte.163.4.427
– volume: 79
  start-page: 49
  year: 2014
  ident: BFijo201647_CR54
  publication-title: Steroids
  doi: 10.1016/j.steroids.2013.10.012
– volume: 5
  start-page: 615S
  year: 2014
  ident: BFijo201647_CR1
  publication-title: Adv Nutr
  doi: 10.3945/an.113.005678
– volume: 53
  start-page: 39
  year: 2003
  ident: BFijo201647_CR10
  publication-title: Arch Latinoam Nutr
– volume: 75
  start-page: 475
  year: 2011
  ident: BFijo201647_CR7
  publication-title: Clin Endocrinol (Oxf)
  doi: 10.1111/j.1365-2265.2011.04085.x
– volume: 292
  start-page: E1724
  year: 2007
  ident: BFijo201647_CR40
  publication-title: Am J Physiol Endocrinol Metab
  doi: 10.1152/ajpendo.00717.2006
– volume: 151
  start-page: 1030
  year: 2010
  ident: BFijo201647_CR22
  publication-title: Endocrinology
  doi: 10.1210/en.2009-0934
– volume: 8
  start-page: e60853
  year: 2013
  ident: BFijo201647_CR64
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0060853
– volume: 33
  start-page: 2501
  year: 2013
  ident: BFijo201647_CR49
  publication-title: Arterioscler Thromb Vasc Biol
  doi: 10.1161/ATVBAHA.113.301948
– volume: 40
  start-page: 1387
  year: 2004
  ident: BFijo201647_CR17
  publication-title: Hepatology
  doi: 10.1002/hep.20466
– volume: 56
  start-page: 2188
  year: 2012
  ident: BFijo201647_CR52
  publication-title: Hepatology
  doi: 10.1002/hep.25961
– volume: 33
  start-page: 859
  year: 2013
  ident: BFijo201647_CR4
  publication-title: Clin Nutr
  doi: 10.1016/j.clnu.2013.10.008
– volume: 2012
  start-page: 374346
  year: 2012
  ident: BFijo201647_CR20
  publication-title: Oxid Med Cell Longev
  doi: 10.1155/2012/374346
– volume: 289
  start-page: 20462
  year: 2014
  ident: BFijo201647_CR37
  publication-title: J Biol Chem
  doi: 10.1074/jbc.R114.576355
– volume: 59
  start-page: 1092
  year: 2010
  ident: BFijo201647_CR55
  publication-title: Metabolism
  doi: 10.1016/j.metabol.2009.11.006
– volume: 290
  start-page: G852
  year: 2006
  ident: BFijo201647_CR43
  publication-title: Am J Physiol Gastrointest Liver Physiol
  doi: 10.1152/ajpgi.00521.2005
– volume: 56
  start-page: 319
  year: 2014
  ident: BFijo201647_CR60
  publication-title: J Lipid Res
  doi: 10.1194/jlr.M054544
– volume: 47
  start-page: 699
  year: 1998
  ident: BFijo201647_CR9
  publication-title: Diabetes
  doi: 10.2337/diabetes.47.5.699
– volume: 141
  start-page: 1403 e1
  year: 2011
  ident: BFijo201647_CR61
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2011.06.040
– volume: 25
  start-page: 191
  year: 1950
  ident: BFijo201647_CR26
  publication-title: Arch Biochem
– volume: 20
  start-page: 1876
  year: 2012
  ident: BFijo201647_CR65
  publication-title: Obesity (Silver Spring)
  doi: 10.1038/oby.2011.34
– volume: 6
  start-page: 800
  year: 2014
  ident: BFijo201647_CR38
  publication-title: World J Hepatol
  doi: 10.4254/wjh.v6.i11.800
– volume: 47
  start-page: 81
  year: 2011
  ident: BFijo201647_CR31
  publication-title: J Mol Endocrinol
  doi: 10.1530/JME-11-0001
– volume: 28
  start-page: 412
  year: 1985
  ident: BFijo201647_CR24
  publication-title: Diabetologia
  doi: 10.1007/BF00280883
– volume: 26
  start-page: 398
  year: 2015
  ident: BFijo201647_CR32
  publication-title: J Nutr Biochem
  doi: 10.1016/j.jnutbio.2014.11.013
– reference: 17299079 - Am J Physiol Endocrinol Metab. 2007 Jun;292(6):E1724-39
– reference: 21372806 - Obesity (Silver Spring). 2012 Sep;20(9):1876-81
– reference: 21660078 - Obesity (Silver Spring). 2012 Jan;20(1):76-87
– reference: 21388699 - Diabetes Res Clin Pract. 2011 May;92(2):228-37
– reference: 15699220 - Am J Clin Nutr. 2005 Feb;81(2):341-54
– reference: 23445212 - Clin Endocrinol (Oxf). 2013 Sep;79(3):314-5
– reference: 24030551 - Arterioscler Thromb Vasc Biol. 2013 Nov;33(11):2501-8
– reference: 12942870 - Arch Latinoam Nutr. 2003 Mar;53(1):39-46
– reference: 25266916 - Food Funct. 2014 Dec;5(12):3117-31
– reference: 24907277 - J Biol Chem. 2014 Jul 25;289(30):20462-9
– reference: 17332780 - Appl Physiol Nutr Metab. 2007 Feb;32(1):4-12
– reference: 25469407 - Adv Nutr. 2014 Sep;5(5):615S-623S
– reference: 15401229 - Arch Biochem. 1950 Jan;25(1):191-200
– reference: 15004215 - J Pharmacol Exp Ther. 2004 Jun;309(3):1282-90
– reference: 24182766 - Clin Nutr. 2014 Oct;33(5):859-66
– reference: 12029625 - Hepatology. 2002 Jun;35(6):1400-8
– reference: 3899825 - Diabetologia. 1985 Jul;28(7):412-9
– reference: 25429318 - World J Hepatol. 2014 Nov 27;6(11):800-11
– reference: 24189185 - Steroids. 2014 Jan;79:49-63
– reference: 25469014 - World J Gastroenterol. 2014 Nov 28;20(44):16464-73
– reference: 25104046 - J Bioenerg Biomembr. 2015 Apr;47(1-2):1-11
– reference: 9588440 - Diabetes. 1998 May;47(5):699-713
– reference: 24318424 - Cochrane Database Syst Rev. 2013 Dec 06;(12):CD002128
– reference: 25366323 - Br J Nutr. 2014 Dec 28;112(12 ):2049-59
– reference: 17786636 - Drug Metab Rev. 2007;39(2-3):515-38
– reference: 15556298 - Gene. 2004 Sep 29;340(1):99-109
– reference: 21610007 - J Mol Endocrinol. 2011 Aug 03;47(1):81-97
– reference: 22149719 - Ann Med. 2012 Dec;44(8):758-72
– reference: 12588201 - Arch Intern Med. 2003 Feb 24;163(4):427-36
– reference: 15565570 - Hepatology. 2004 Dec;40(6):1387-95
– reference: 11296696 - Semin Liver Dis. 2001;21(1):43-55
– reference: 24133660 - Clin Mol Hepatol. 2013 Sep;19(3):210-5
– reference: 20060143 - Metabolism. 2010 Aug;59(8):1092-105
– reference: 16603729 - Am J Physiol Gastrointest Liver Physiol. 2006 May;290(5):G852-8
– reference: 10535456 - Diabetes. 1999 Nov;48(11):2210-4
– reference: 13428781 - J Biol Chem. 1957 May;226(1):497-509
– reference: 23472739 - Public Health Nutr. 2014 Mar;17 (3):486-97
– reference: 24551121 - PLoS One. 2014 Feb 14;9(2):e88584
– reference: 25476792 - Food Nutr Res. 2014 Dec 03;58:24114
– reference: 21944063 - J Nutr Biochem. 2012 Sep;23(9):1041-50
– reference: 16950652 - Biochim Biophys Acta. 2006 Sep;1761(9):1107-13
– reference: 23071592 - PLoS One. 2012;7(10):e46584
– reference: 22806626 - Hepatology. 2012 Dec;56(6):2188-98
– reference: 24099723 - Nutr Metab Cardiovasc Dis. 2014 Jan;24(1):100-6
– reference: 942051 - Anal Biochem. 1976 May 7;72:248-54
– reference: 21186103 - Nutr Metab Cardiovasc Dis. 2012 Jul;22(7):567-74
– reference: 25378657 - J Lipid Res. 2015 Feb;56(2):319-30
– reference: 26063331 - Int J Obes (Lond). 2015 Nov;39(11):1619-29
– reference: 17167477 - Nature. 2006 Dec 14;444(7121):881-7
– reference: 12468409 - Best Pract Res Clin Endocrinol Metab. 2002 Dec;16(4):595-610
– reference: 25660595 - J Nutr Biochem. 2015 Apr;26(4):398-407
– reference: 24295779 - Biochim Biophys Acta. 2014 Feb;1841(2):267-78
– reference: 21521351 - Clin Endocrinol (Oxf). 2011 Oct;75(4):475-81
– reference: 20300478 - PPAR Res. 2009;2009:952734
– reference: 23396451 - Am J Physiol Heart Circ Physiol. 2013 Apr 15;304(8):H1060-76
– reference: 2218183 - Stat Med. 1990 Jul;9(7):811-8
– reference: 6166661 - J Histochem Cytochem. 1981 Apr;29(4):577-80
– reference: 23320128 - Oxid Med Cell Longev. 2012;2012:374346
– reference: 21703998 - Gastroenterology. 2011 Oct;141(4):1393-403, 1403.e1-5
– reference: 17320029 - Anal Biochem. 2007 Apr 15;363(2):315-7
– reference: 21147110 - Gastroenterology. 2011 Mar;140(3):1071-83
– reference: 23593328 - PLoS One. 2013 Apr 11;8(4):e60853
– reference: 24971303 - Int J High Risk Behav Addict. 2014 Mar 10;3(1):e8725
– reference: 14726172 - Lancet. 2004 Jan 10;363(9403):163
– reference: 20068006 - Endocrinology. 2010 Mar;151(3):1030-41
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Snippet Background/Objectives: Consumption of fat-rich foods is associated with obesity and related alterations. However, there is a group of individuals, the...
Consumption of fat-rich foods is associated with obesity and related alterations. However, there is a group of individuals, the metabolically obese...
BACKGROUND/OBJECTIVES: Consumption of fat-rich foods is associated with obesity and related alterations. However, there is a group of individuals, the...
International Journal of Obesity (2016) 40, 1250-1259; doi: 10.1038/ijo.2016.47
Background/Objectives:Consumption of fat-rich foods is associated with obesity and related alterations. However, there is a group of individuals, the...
Background/ Objectives: Consumption of fat-rich foods is associated with obesity and related alterations. However, there is a group of individuals, the...
Background/Objectives: Consumption of fat-rich foods is associated with obesity and related alterations. However, there is a group of individuals, the...
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Adaptation
Adiposity
Animal Nutritional Physiological Phenomena
Animals
Biomarkers
Blotting, Western
Body Weight
Carbohydrates
Cholesterol
Cholesterol - blood
Cholesterol - metabolism
Deposition
Diet
Diet, High-Fat - adverse effects
Disease Models, Animal
Down-Regulation
Energy Intake
Epidemiology
Fat metabolism
Fatty liver
Fatty Liver - etiology
Fatty Liver - genetics
Fatty Liver - metabolism
Fatty Liver - pathology
Food consumption
Fysiologie van Mens en Dier
Gene expression
Genomes
Health aspects
Health Promotion and Disease Prevention
High fat diet
Human and Animal Physiology
Hyperphagia
Immunohistochemistry
Insulin resistance
Internal Medicine
Keratins, Type I - analysis
Keratins, Type I - genetics
Ketogenic diet
Laboratories
Leerstoelgroep Fysiologie van mens en dier
Lipid metabolism
Lipid Metabolism - genetics
Lipids
Liver
Liver - chemistry
Liver - metabolism
Liver cancer
Liver diseases
Male
Medicine
Medicine & Public Health
Metabolic Diseases
Metabolic disorders
Metabolism
Molecular biology
Nutrition research
Obesity
Obesity - metabolism
original-article
Overweight
Physiological aspects
Public Health
Rats
Rats, Wistar
Risk
Risk factors
Transcriptome
Transcriptomes
Triglycerides
Up-Regulation
VLAG
WIAS
Title Isocaloric high-fat feeding directs hepatic metabolism to handling of nutrient imbalance promoting liver fat deposition
URI https://link.springer.com/article/10.1038/ijo.2016.47
https://www.ncbi.nlm.nih.gov/pubmed/27089994
https://www.proquest.com/docview/1808045269
https://www.proquest.com/docview/2639132209
https://www.proquest.com/docview/1808602476
https://www.proquest.com/docview/1811894300
http://www.narcis.nl/publication/RecordID/oai:library.wur.nl:wurpubs%2F506901
Volume 40
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