Murine model and mechanisms of treatment-induced painful diabetic neuropathy

• Published in: Neuroscience Vol. 354; pp. 136 - 145
• Main Authors: Nicodemus, Juliet M., Enriquez, Cynthia, Marquez, Alexandra, Anaya, Carlos J., Jolivalt, Corinne G.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Ltd 23.06.2017
• Subjects: Amines - therapeutic use; Animals; Cyclohexanecarboxylic Acids - therapeutic use; diabetes; Diabetic Neuropathies - complications; Diabetic Neuropathies - genetics; Diabetic Neuropathies - therapy; Disease Models, Animal; Enzyme Inhibitors - pharmacology; Excitatory Amino Acid Antagonists - therapeutic use; Female; gamma-Aminobutyric Acid - therapeutic use; Guanine Nucleotide Exchange Factors - genetics; Guanine Nucleotide Exchange Factors - metabolism; Hyperalgesia - etiology; Hypoglycemic Agents - toxicity; insulin; Insulin - toxicity; insulin neuritis; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neural Conduction - genetics; Neural Conduction - physiology; Neuralgia - complications; Neuralgia - genetics; Neuralgia - therapy; Neurology; neuropathy; Pain Threshold - physiology; Reaction Time - physiology; Receptor, Insulin - deficiency; Receptor, Insulin - genetics; Receptors, Leptin - genetics; Receptors, Leptin - metabolism; TIND; MNCV; insulin; HFD; IR-KD; neuropathy; IGF1; LFD; PWT; TIND; diabetes; insulin neuritis; treatment-induced painful neuropathy of diabetes; Insulin-like Growth Factor 1; low-fat diet; 50% paw withdrawal threshold; high-fat diet; motor nerve conduction velocity; inducible insulin receptor knockdown

•Insulin induces neuropathic pain in high-fat diet mice.•Insulin-induced pain is independent of glucose levels.•Our murine model of treatment-induced neuropathy of diabetes provides evidence for an insulin-IGF1 pathway-based mechanism. Diabetes mellitus represents a group of metabolic diseases that...