Renal tubular Sirt1 attenuates diabetic albuminuria by epigenetically suppressing Claudin-1 overexpression in podocytes

• Published in: Nature medicine Vol. 19; no. 11; pp. 1496 - 1504
• Main Authors: Hasegawa, Kazuhiro, Wakino, Shu, Simic, Petra, Sakamaki, Yusuke, Minakuchi, Hitoshi, Fujimura, Keiko, Hosoya, Kozi, Komatsu, Motoaki, Kaneko, Yuka, Kanda, Takeshi, Kubota, Eiji, Tokuyama, Hirobumi, Hayashi, Koichi, Guarente, Leonard, Itoh, Hiroshi
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.11.2013; Nature Publishing Group
• Subjects: 692/699/1585/104; 692/699/2743/137/138; Adult; Aged; Aged, 80 and over; Albuminuria; Albuminuria - genetics; Albuminuria - metabolism; Animals; Biomedicine; Cancer Research; Claudin-1 - genetics; Claudin-1 - metabolism; Diabetes; Diabetes Mellitus - genetics; Diabetes Mellitus - metabolism; Diabetes Mellitus, Experimental - genetics; Diabetes Mellitus, Experimental - metabolism; Diabetic nephropathies; Diabetic neuropathy; Epigenesis, Genetic; Epigenetics; Epithelial cells; Female; Fluorescence; Gene expression; Gene Expression Regulation; Genetic aspects; Humans; Infectious Diseases; Injection; Kidney diseases; Kidney Tubules, Proximal - metabolism; Male; Metabolic Diseases; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Obese; Mice, Transgenic; Middle Aged; Molecular Medicine; Neurosciences; Nicotinamide Mononucleotide - metabolism; Podocytes - metabolism; Prevention; Proteins; Sirtuin 1 - deficiency; Sirtuin 1 - genetics; Sirtuin 1 - metabolism; Suppression, Genetic; United States; Japan

Diabetic nephropathy is the most common cause of end-stage renal disease. Shu Wakino and colleagues now show that high-glucose conditions in the renal proximal tubules result in downregulation of Sirt1 expression there and in the glomeruli, resulting in epigentic upregulation of Claudin-1 in the glo...