Renal tubular Sirt1 attenuates diabetic albuminuria by epigenetically suppressing Claudin-1 overexpression in podocytes - Hasegawa, Kazuhiro; Wakino, Shu; Simic, Petra; Sakamaki, Yusuke; Minakuchi, Hitoshi; Fujimura, Keiko; Hosoya, Kozi; Komatsu, Motoaki; Kaneko, Yuka; Kanda, Takeshi; Kubota, Eiji; Tokuyama, Hirobumi; et al. (Nature medicine, 2013)
Keywords: 692/699/1585/104; 692/699/2743/137/138; Adult; Aged; Aged, 80 and over; Albuminuria; Albuminuria - genetics; Albuminuria - metabolism; Animals; Biomedicine; Cancer Research; Claudin-1 - genetics; Claudin-1 - metabolism; Diabetes; Diabetes Mellitus - genetics; Diabetes Mellitus - metabolism; Diabetes Mellitus, Experimental - genetics; Diabetes Mellitus, Experimental - metabolism; Diabetic nephropathies; Diabetic neuropathy; Epigenesis, Genetic; Epigenetics; Epithelial cells; Female; Fluorescence; Gene expression; Gene Expression Regulation; Genetic aspects; Humans; Infectious Diseases; Injection; Kidney diseases; Kidney Tubules, Proximal - metabolism; Male; Metabolic Diseases; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Obese; Mice, Transgenic; Middle Aged; Molecular Medicine; Neurosciences; Nicotinamide Mononucleotide - metabolism; Podocytes - metabolism; Prevention; Proteins; Sirtuin 1 - deficiency; Sirtuin 1 - genetics; Sirtuin 1 - metabolism; Suppression, Genetic; United States; Japan