Leukotrienes in Nociceptive Pathway and Neuropathic/Inflammatory Pain

• Published in: Biological & Pharmaceutical Bulletin Vol. 34; no. 8; pp. 1163 - 1169
• Main Authors: Noguchi, Koichi, Okubo, Masamichi
• Format: Journal Article
• Language: English; Japanese
• Published: Japan The Pharmaceutical Society of Japan 2011; Pharmaceutical Society of Japan; Japan Science and Technology Agency
• Subjects: Animals; dorsal root ganglion neuron; Ganglia, Spinal - metabolism; Hyperalgesia - etiology; Hyperalgesia - metabolism; Inflammation - complications; Inflammation - metabolism; Inflammation Mediators - metabolism; inflammatory pain; leukotriene; Leukotrienes - metabolism; microglia; Neuralgia - etiology; Neuralgia - metabolism; neuropathic pain; p38 Mitogen-Activated Protein Kinases - metabolism; Peripheral Nervous System - injuries; Peripheral Nervous System - metabolism; Peripheral Nervous System Diseases - etiology; Peripheral Nervous System Diseases - metabolism; Receptors, Leukotriene - metabolism; RNA, Messenger - metabolism; spinal cord; Spinal Cord - cytology; Spinal Cord - metabolism

The purpose of this review is to summarize the recent studies examining the expression of leukotrienes (LTs) and their receptors in nociceptive pathways, and their crucial roles in pathological pain conditions. LTs belong to a large family of lipid mediators, termed eicosanoids, which are derived fr...