Toxoplasma Effector MAF1 Mediates Recruitment of Host Mitochondria and Impacts the Host Response

• Published in: PLoS biology Vol. 12; no. 4; p. e1001845
• Main Authors: Pernas, Lena, Adomako-Ankomah, Yaw, Shastri, Anjali J., Ewald, Sarah E., Treeck, Moritz, Boyle, Jon P., Boothroyd, John C.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.04.2014; Public Library of Science (PLoS)
• Subjects: Animals; Animals, Genetically Modified; Apoptosis; Bacteria; Bioinformatics; Biology and Life Sciences; Colleges & universities; Cytokines - metabolism; Dihydrofolate reductase; Female; Health aspects; Host-parasite relationships; Immune system; Immunity, Innate; Infections; Mice; Mice, Inbred C57BL; Microbiological research; Mitochondria; Mitochondria - parasitology; Parasites; Proteins; Protozoan Proteins - genetics; Protozoan Proteins - immunology; Protozoan Proteins - metabolism; Research and Analysis Methods; Toxoplasma; Toxoplasma - classification; Toxoplasma - immunology; Toxoplasma - pathogenicity; Toxoplasmosis - immunology; Toxoplasmosis - parasitology; Toxoplasmosis - pathology; Vacuoles - parasitology

Recent information has revealed the functional diversity and importance of mitochondria in many cellular processes including orchestrating the innate immune response. Intriguingly, several infectious agents, such as Toxoplasma, Legionella, and Chlamydia, have been reported to grow within vacuoles su...