Evaluation of Placentation and the Role of the Aryl Hydrocarbon Receptor Pathway in a Rat Model of Dioxin Exposure

• Published in: Environmental health perspectives Vol. 129; no. 11; p. 117001
• Main Authors: Iqbal, Khursheed, Pierce, Stephen H, Kozai, Keisuke, Dhakal, Pramod, Scott, Regan L, Roby, Katherine F, Vyhlidal, Carrie A, Soares, Michael J
• Format: Journal Article
• Language: English
• Published: United States National Institute of Environmental Health Sciences 01.11.2021; Environmental Health Perspectives
• Subjects: Adaptation; Age; Animal models; Animals; Aromatic compounds; Carbon dioxide; Cardiovascular system; CRISPR; Cytochrome; Cytochrome P-450 CYP1A1 - genetics; Cytochrome P-450 CYP1A1 - metabolism; Cytochrome P450; Cytochromes P450; Dioxin; Dioxins; Dioxins - toxicity; Embryogenesis; Embryos; Endothelial cells; Endothelial Cells - metabolism; Environmental aspects; Evaluation; Exposure; Female; Females; Fetuses; Genetic aspects; Genetic engineering; Genomes; Health aspects; Hydrocarbons; Ligands; Mutation; Ostomy; Phenotyping; Physiological aspects; Placenta; Placenta - metabolism; Placentation; Polychlorinated Dibenzodioxins - toxicity; Pregnancy; Rats; Receptors; Receptors, Aryl Hydrocarbon - metabolism; Rodents; Signal transduction; Signaling; TCDD; Transcription factors; Trophoblasts - drug effects; Uterus; United States

Our environment is replete with chemicals that can affect embryonic and extraembryonic development. Dioxins, such as 2,3,7,8-tetrachlorodibenzo- -dioxin (TCDD), are compounds affecting development through the aryl hydrocarbon receptor (AHR). The purpose of this investigation was to examine the effec...