Mutations of Chromosome 5q21 Genes in FAP and Colorectal Cancer Patients

• Published in: Science (American Association for the Advancement of Science) Vol. 253; no. 5020; pp. 665 - 669
• Main Authors: Nishisho, Isamu, Nakamura, Yusuke, Miyoshi, Yasuo, Miki, Yoshio, Ando, Hiroshi, Horii, Akira, Koyama, Kumiko, Utsunomiya, Joji, Baba, Shozo, Hedge, Philip, Markham, Alex, Krush, Anne J., Petersen, Gloria, Hamilton, Stanley R., Nilbert, Mef C., Levy, Daniel B., Bryan, Tracy M., Preisinger, Antonette C., Smith, Kelly J., Su, Li-Kuo, Kinzler, Kenneth W., Vogelstein, Bert
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for the Advancement of Science 09.08.1991; American Association for the Advancement of Science; The American Association for the Advancement of Science
• Subjects: Adenomatous Polyposis Coli - genetics; Amino Acid Sequence; APC genes; Base Sequence; Biological and medical sciences; Cancer; Cell lines; Chromosome abnormalities; Chromosome Mapping; Chromosomes, Human, Pair 5; Codon - genetics; Codons; Colonic Neoplasms - genetics; Colorectal cancer; DNA; DNA, Neoplasm - genetics; DNA, Neoplasm - isolation & purification; Exons; Familial polyposis; Gastroenterology. Liver. Pancreas. Abdomen; Genetic aspects; Genetic Linkage; Genetic mutation; Genetic Variation; Genetics; Humans; Medical research; Medical sciences; Molecular Sequence Data; Mutation; Oligonucleotide Probes; Point mutation; Polymerase chain reaction; Polymerase Chain Reaction - methods; Polyposis, Familial; Rectal Neoplasms - genetics; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Tumors; Human; B5-Chromosome; Inheritance; Rectum; Digestive diseases; Tumor; Colon; Mutation; Malignant tumor; Polyp

Previous studies suggested that one or more genes on chromosome 5q21 are responsible for the inheritance of familial adenomatous polyposis (FAP) and Gardner's syndrome (GS), and contribute to tumor development in patients with noninherited forms of colorectal cancer. Two genes on 5q21 that are...