HIV reservoirs: what, where and how to target them

• Published in: Nature reviews. Microbiology Vol. 14; no. 1; pp. 55 - 60
• Main Authors: Churchill, Melissa J., Deeks, Steven G., Margolis, David M., Siliciano, Robert F., Swanstrom, Ronald
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.01.2016; Nature Publishing Group
• Subjects: 631/250/255/1901; 631/326/596/1787; 631/326/596/2564; Anti-HIV Agents - therapeutic use; Antiretroviral agents; Beliefs, opinions and attitudes; Biomedical and Life Sciences; Care and treatment; Complications and side effects; Development and progression; Health aspects; Highly active antiretroviral therapy; HIV - drug effects; HIV - physiology; HIV infections; HIV Infections - drug therapy; HIV Infections - virology; Host-virus relationships; Human immunodeficiency virus; Humans; Immune system; Infectious Diseases; Life Sciences; Medical Microbiology; Medical research; Methods; Microbiology; Models, Animal; Molecular targeted therapy; Observations; Parasitology; Patient outcomes; Physicians; Proviruses - drug effects; Proviruses - physiology; viewpoint; Virology; Virulence (Microbiology); Virus Integration; Virus Latency - drug effects; Australia

Viral reservoirs pose a major challenge in the efforts towards curing HIV. Here, Churchill, Deeks, Margolis, Siliciano and Swanstrom discuss the cells and tissues that constitute the viral reservoir, how best to measure it and how to target this source of persistent infection. One of the main challe...