HIV reservoirs: what, where and how to target them

• Published in: Nature reviews. Microbiology Vol. 14; no. 1; pp. 55 - 60
• Main Authors: Churchill, Melissa J., Deeks, Steven G., Margolis, David M., Siliciano, Robert F., Swanstrom, Ronald
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.01.2016; Nature Publishing Group
• Subjects: 631/250/255/1901; 631/326/596/1787; 631/326/596/2564; Anti-HIV Agents - therapeutic use; Antiretroviral agents; Beliefs, opinions and attitudes; Biomedical and Life Sciences; Care and treatment; Complications and side effects; Development and progression; Health aspects; Highly active antiretroviral therapy; HIV - drug effects; HIV - physiology; HIV infections; HIV Infections - drug therapy; HIV Infections - virology; Host-virus relationships; Human immunodeficiency virus; Humans; Immune system; Infectious Diseases; Life Sciences; Medical Microbiology; Medical research; Methods; Microbiology; Models, Animal; Molecular targeted therapy; Observations; Parasitology; Patient outcomes; Physicians; Proviruses - drug effects; Proviruses - physiology; viewpoint; Virology; Virulence (Microbiology); Virus Integration; Virus Latency - drug effects; Australia
• ISSN: 1740-1526; 1740-1534; 1740-1534
• DOI: 10.1038/nrmicro.2015.5

Viral reservoirs pose a major challenge in the efforts towards curing HIV. Here, Churchill, Deeks, Margolis, Siliciano and Swanstrom discuss the cells and tissues that constitute the viral reservoir, how best to measure it and how to target this source of persistent infection. One of the main challenges in the fight against HIV infection is to develop strategies that are able to eliminate the persistent viral reservoir that harbours integrated, replication-competent provirus within host cellular DNA. This reservoir is resistant to antiretroviral therapy (ART) and to clearance by the immune system of the host; viruses originating from this reservoir lead to rebound viraemia once treatment is stopped, giving rise to new rounds of infection. Several studies have focused on elucidating the cells and tissues that harbour persistent virus, the true size of the reservoir and how best to target it, but these topics are the subject of ongoing debate. In this Viewpoint article, several experts in the field discuss the constitution of the viral reservoir, how best to measure it and the best ways to target this source of persistent infection.