Angiogenic and antifibrotic actions of hepatocyte growth factor improve cardiac dysfunction in porcine ischemic cardiomyopathy

• Published in: Gene therapy Vol. 13; no. 16; pp. 1206 - 1213
• Main Authors: AZUMA, J, TANIYAMA, Y, TAKEYA, Y, IEKUSHI, K, AOKI, M, DOSAKA, N, MATSUMOTO, K, NAKAMURA, T, OGIHARA, T, MORISHITA, R
• Format: Journal Article
• Language: English
• Published: Basingstoke Nature Publishing Group 01.08.2006
• Subjects: Angiogenesis; Animals; Biological and medical sciences; Blood flow; Cardiac function; Cardiology. Vascular system; Cardiomyopathy; Cardiovascular disease; Care and treatment; Cell differentiation, maturation, development, hematopoiesis; Cell physiology; Clinical trials; Collagen (type I); Coronary Angiography; Coronary artery disease; Coronary heart disease; Deoxyribonucleic acid; DNA; DNA - administration & dosage; Echocardiography; Fibrosis; Fundamental and applied biological sciences. Psychology; Gene therapy; Genetic Therapy - methods; Growth factors; Health aspects; Heart; Heart - physiopathology; Heart diseases; Hepatocyte growth factor; Hepatocyte Growth Factor - genetics; Hepatocyte Growth Factor - metabolism; HGF gene; Hogs; Injection; Ischemia; Liver cells; Male; Medical sciences; Models, Animal; Molecular and cellular biology; Myocardial ischemia; Myocardial Ischemia - metabolism; Myocardial Ischemia - physiopathology; Myocardial Ischemia - therapy; Myocarditis. Cardiomyopathies; Myocardium; Neovascularization; Neovascularization, Physiologic; Perfusion; Reverse Transcriptase Polymerase Chain Reaction; Swine; Transduction, Genetic; Transfection - methods; Japan; Cardiomyopathy; Hepatocyte growth factor; HGF; angina; Cardiovascular disease; myocardium; Angina pectoris; Coronary heart disease; Myocardial disease; Pig; Angiogenesis; Vertebrata; Mammalia; Ischemia; Artiodactyla; Gene therapy; Ungulata

Impairment of cardiac function in ischemic cardiomyopathy has been postulated to be due to the decrease in blood flow and increase in collagen synthesis. Therefore, an approach to alter them directly by means of a growth factor may open up a new therapeutic concept in ischemic cardiomyopathy. From t...