Phosphorylation of S122 in ERα is important for the skeletal response to estrogen treatment in male mice

• Published in: Scientific reports Vol. 12; no. 1; p. 22449
• Main Authors: Horkeby, Karin, Farman, Helen H., Movérare-Skrtic, Sofia, Lionikaite, Vikte, Wu, Jianyao, Henning, Petra, Windahl, Sara, Sjögren, Klara, Ohlsson, Claes, Lagerquist, Marie K.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 27.12.2022; Nature Publishing Group; Nature Portfolio
• Subjects: 17β-Estradiol; 692/163; 692/163/2743/316/801; Animals; Body Weight; Bone and Bones - diagnostic imaging; Bone and Bones - metabolism; Bone mineral density; Cancellous bone; Child; Cortical bone; Endocrinology and Diabetes; Endokrinologi och diabetes; Estradiol; Estrogen Receptor alpha - genetics; Estrogen Receptor alpha - metabolism; Estrogen receptors; Estrogens; Estrogens - pharmacology; Humanities and Social Sciences; Humans; Infant; Male; Males; Medicin och hälsovetenskap; Mice; multidisciplinary; Osteoporosis; Phosphorylation; Science; Science (multidisciplinary); Skeleton; Tibia; Tissues

Estrogen receptor alpha (ERα) signaling has beneficial skeletal effects in males. ERα signaling also affects other tissues, and to find bone-specific treatments, more knowledge regarding tissue-specific ERα signaling is needed. ERα is subjected to posttranslational modifications, including phosphory...