Loss of the RNA-binding protein TACO1 causes late-onset mitochondrial dysfunction in mice

• Published in: Nature communications Vol. 7; no. 1; p. 11884
• Main Authors: Richman, Tara R., Spåhr, Henrik, Ermer, Judith A., Davies, Stefan M. K., Viola, Helena M., Bates, Kristyn A., Papadimitriou, John, Hool, Livia C., Rodger, Jennifer, Larsson, Nils-Göran, Rackham, Oliver, Filipovska, Aleksandra
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 20.06.2016; Nature Publishing Group; Nature Portfolio
• Subjects: 631/337/574/1789; 631/45/612/1230; 64/60; 692/699; Amino Acid Sequence; Animals; Binding Sites; Biochemistry; Biology; Cardiomegaly - genetics; Cardiomegaly - metabolism; Cardiomegaly - pathology; Cloning, Molecular; Crystallography, X-Ray; Cytochrome; Dystonia; Escherichia coli - genetics; Escherichia coli - metabolism; Genes; Genomes; Heart; Humanities and Social Sciences; Male; Medical research; Medicin och hälsovetenskap; Metabolism; Mice; Mice, Knockout; Microfilament Proteins - chemistry; Microfilament Proteins - genetics; Microfilament Proteins - metabolism; Mitochondria; Mitochondria - metabolism; Mitochondria - pathology; Mitochondrial Diseases - genetics; Mitochondrial Diseases - metabolism; Mitochondrial Diseases - pathology; Mitochondrial Proteins - chemistry; Mitochondrial Proteins - genetics; Mitochondrial Proteins - metabolism; Models, Molecular; multidisciplinary; Mutation; Protein Binding; Protein Biosynthesis; Protein Conformation, alpha-Helical; Protein Conformation, beta-Strand; Protein Interaction Domains and Motifs; Proteins; Recombinant Proteins - chemistry; Recombinant Proteins - genetics; Recombinant Proteins - metabolism; Ribonucleic acid; RNA; RNA, Messenger - chemistry; RNA, Messenger - metabolism; Science; Science (multidisciplinary); Sequence Alignment; Sequence Homology, Amino Acid; Visual impairment; Australia; Western Australia Australia

The recognition and translation of mammalian mitochondrial mRNAs are poorly understood. To gain further insights into these processes in vivo, we characterized mice with a missense mutation that causes loss of the translational activator of cytochrome oxidase subunit I (TACO1). We report that TACO1...