Loss of the RNA-binding protein TACO1 causes late-onset mitochondrial dysfunction in mice

The recognition and translation of mammalian mitochondrial mRNAs are poorly understood. To gain further insights into these processes in vivo, we characterized mice with a missense mutation that causes loss of the translational activator of cytochrome oxidase subunit I (TACO1). We report that TACO1...

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Published inNature communications Vol. 7; no. 1; p. 11884
Main Authors Richman, Tara R., Spåhr, Henrik, Ermer, Judith A., Davies, Stefan M. K., Viola, Helena M., Bates, Kristyn A., Papadimitriou, John, Hool, Livia C., Rodger, Jennifer, Larsson, Nils-Göran, Rackham, Oliver, Filipovska, Aleksandra
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Published London Nature Publishing Group UK 20.06.2016
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Abstract The recognition and translation of mammalian mitochondrial mRNAs are poorly understood. To gain further insights into these processes in vivo, we characterized mice with a missense mutation that causes loss of the translational activator of cytochrome oxidase subunit I (TACO1). We report that TACO1 is not required for embryonic survival, although the mutant mice have substantially reduced COXI protein, causing an isolated complex IV deficiency. We show that TACO1 specifically binds the mt-Co1 mRNA and is required for translation of COXI through its association with the mitochondrial ribosome. We determined the atomic structure of TACO1, revealing three domains in the shape of a hook with a tunnel between domains 1 and 3. Mutations in the positively charged domain 1 reduce RNA binding by TACO1. The Taco1 mutant mice develop a late-onset visual impairment, motor dysfunction and cardiac hypertrophy and thus provide a useful model for future treatment trials for mitochondrial disease. Mutations in the translational activator of cytochrome c oxidase subunit I (TACO1) causes cytochrome c oxidase deficiency and Leigh Syndrome in patients. Here, the authors characterize mice with a mutation that causes lack of TACO1 expression, identifying a mouse model that could be useful for preclinical trials.
AbstractList The recognition and translation of mammalian mitochondrial mRNAs are poorly understood. To gain further insights into these processes in vivo, we characterized mice with a missense mutation that causes loss of the translational activator of cytochrome oxidase subunit I (TACO1). We report that TACO1 is not required for embryonic survival, although the mutant mice have substantially reduced COXI protein, causing an isolated complex IV deficiency. We show that TACO1 specifically binds the mt-Co1 mRNA and is required for translation of COXI through its association with the mitochondrial ribosome. We determined the atomic structure of TACO1, revealing three domains in the shape of a hook with a tunnel between domains 1 and 3. Mutations in the positively charged domain 1 reduce RNA binding by TACO1. The Taco1 mutant mice develop a late-onset visual impairment, motor dysfunction and cardiac hypertrophy and thus provide a useful model for future treatment trials for mitochondrial disease.
Mutations in the translational activator of cytochrome c oxidase subunit I (TACO1) causes cytochrome c oxidase deficiency and Leigh Syndrome in patients. Here, the authors characterize mice with a mutation that causes lack of TACO1 expression, identifying a mouse model that could be useful for preclinical trials.
The recognition and translation of mammalian mitochondrial mRNAs are poorly understood. To gain further insights into these processes in vivo, we characterized mice with a missense mutation that causes loss of the translational activator of cytochrome oxidase subunit I (TACO1). We report that TACO1 is not required for embryonic survival, although the mutant mice have substantially reduced COXI protein, causing an isolated complex IV deficiency. We show that TACO1 specifically binds the mt-Co1 mRNA and is required for translation of COXI through its association with the mitochondrial ribosome. We determined the atomic structure of TACO1, revealing three domains in the shape of a hook with a tunnel between domains 1 and 3. Mutations in the positively charged domain 1 reduce RNA binding by TACO1. The Taco1 mutant mice develop a late-onset visual impairment, motor dysfunction and cardiac hypertrophy and thus provide a useful model for future treatment trials for mitochondrial disease.
The recognition and translation of mammalian mitochondrial mRNAs are poorly understood. To gain further insights into these processes in vivo, we characterized mice with a missense mutation that causes loss of the translational activator of cytochrome oxidase subunit I (TACO1). We report that TACO1 is not required for embryonic survival, although the mutant mice have substantially reduced COXI protein, causing an isolated complex IV deficiency. We show that TACO1 specifically binds the mt-Co1 mRNA and is required for translation of COXI through its association with the mitochondrial ribosome. We determined the atomic structure of TACO1, revealing three domains in the shape of a hook with a tunnel between domains 1 and 3. Mutations in the positively charged domain 1 reduce RNA binding by TACO1. The Taco1 mutant mice develop a late-onset visual impairment, motor dysfunction and cardiac hypertrophy and thus provide a useful model for future treatment trials for mitochondrial disease. Mutations in the translational activator of cytochrome c oxidase subunit I (TACO1) causes cytochrome c oxidase deficiency and Leigh Syndrome in patients. Here, the authors characterize mice with a mutation that causes lack of TACO1 expression, identifying a mouse model that could be useful for preclinical trials.
ArticleNumber 11884
Author Richman, Tara R.
Papadimitriou, John
Rackham, Oliver
Davies, Stefan M. K.
Viola, Helena M.
Rodger, Jennifer
Hool, Livia C.
Ermer, Judith A.
Bates, Kristyn A.
Spåhr, Henrik
Filipovska, Aleksandra
Larsson, Nils-Göran
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Cites_doi 10.1038/ng.390
10.1002/prot.10286
10.1016/0091-3057(80)90067-2
10.1107/S0907444904019158
10.1074/jbc.M513805200
10.1038/nature11707
10.1107/S0907444901014007
10.1111/j.1432-1033.1996.00779.x
10.1016/j.cmet.2014.07.001
10.1093/hmg/ddp477
10.1107/S0907444909052925
10.1016/j.cell.2011.06.051
10.1093/nar/gks506
10.1007/s00213-002-1009-2
10.1016/j.visres.2004.12.015
10.1091/mbc.e06-09-0803
10.1126/science.aaa1193
10.1107/S0021889893005588
10.1093/bioinformatics/btn507
10.1073/pnas.132241399
10.4161/rna.6.2.8050
10.1016/j.mib.2013.07.011
10.1016/j.bbamcr.2012.03.007
10.1016/j.bbadis.2009.07.013
10.1002/prot.24841
10.1093/nar/gkp627
10.1007/978-1-4614-3573-0_14
10.1017/S1355838201010299
10.1038/nprot.2008.61
10.1016/j.nmd.2010.06.017
10.1126/science.aaa3872
10.1093/hmg/ddl477
10.1046/j.1432-1327.1998.2540389.x
10.1038/nprot.2006.62
10.1098/rsob.120061
10.1186/1752-0509-6-S1-S20
10.1093/nar/gkt376
10.1038/emboj.2011.392
10.1007/BF01952112
10.1038/emboj.2012.300
10.1136/jnnp.14.3.216
10.1016/j.bbabio.2011.06.010
10.1016/S0891-5849(01)00576-7
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References Andrews (CR15) 2012; 2
Shin, Yokota, Kim, Kim (CR19) 2002; 99
Small, Rackham, Filipovska (CR4) 2013; 16
Holm, Kääriäinen, Rosenström, Schenkel (CR17) 2008; 24
Leigh (CR10) 1951; 14
Davies, Poljak, Duncan, Smythe, Murphy (CR32) 2001; 31
Diaz (CR12) 2010; 1802
Duvezin-Caubet (CR21) 2006; 281
Rackham (CR28) 2009; 37
Lovell (CR39) 2003; 50
CR38
Fox (CR3) 1996; 52
Jiang, Guerrier-Takada, Altman (CR24) 2001; 7
Seeger (CR14) 2010; 20
Emsley, Cowtan (CR37) 2004; 60
Distelmaier, Smeitink, Willems, Koopman (CR11) 2012; 32
Zambrano (CR2) 2007; 18
Perrakis, Harkiolaki, Wilson, Lamzin (CR36) 2001; 57
Rötig (CR7) 2011; 1807
Del Bel, Souza, Guimarães, da-Silva, Nucci-da-Silva (CR42) 2002; 161
Bailey, Elkan (CR45) 1993; 2
Weraarpachai (CR9) 2009; 41
Adams (CR35) 2010; 66
Yang (CR26) 2009; 19
Dell'Agnello (CR27) 2007; 16
Vafai, Mootha (CR8) 2012; 491
Franklin (CR18) 2015; 83
Amunts, Brown, Toots, Scheres, Ramakrishnan (CR5) 2015; 348
Nijtmans, Taanman, Muijsers, Speijer, Van den Bogert (CR16) 1998; 254
Hallberg, Larsson (CR1) 2014; 20
Crawley, Goodwin (CR40) 1980; 13
Wittig, Braun, Schägger (CR31) 2006; 1
Chujo (CR23) 2012; 40
Herrmann, Woellhaf, Bonnefoy (CR20) 2013; 1833
Kuznetsov (CR33) 2008; 3
McWilliam (CR44) 2013; 41
Ruzzenente (CR29) 2012; 31
Kabsch (CR34) 1993; 26
Claros, Vincens (CR43) 1996; 241
Mercer (CR22) 2011; 146
Abdeljalil (CR41) 2005; 45
Dimauro, Tanji, Schon (CR13) 2012; 748
Zhang, Lin, Gao (CR25) 2012; 6
Greber (CR6) 2015; 348
Coughlin, Babak, Nihranz, Hughes, Engelke (CR30) 2009; 6
25838379 - Science. 2015 Apr 3;348(6230):95-8
19503089 - Nat Genet. 2009 Jul;41(7):833-7
14874135 - J Neurol Neurosurg Psychiatry. 1951 Aug;14(3):216-21
6106204 - Pharmacol Biochem Behav. 1980 Aug;13(2):167-70
15572765 - Acta Crystallogr D Biol Crystallogr. 2004 Dec;60(Pt 12 Pt 1):2126-32
11567158 - Acta Crystallogr D Biol Crystallogr. 2001 Oct;57(Pt 10):1445-50
19246989 - RNA Biol. 2009 Apr-Jun;6(2):195-202
20727754 - Neuromuscul Disord. 2010 Nov;20(11):720-4
23671338 - Nucleic Acids Res. 2013 Jul;41(Web Server issue):W597-600
12557186 - Proteins. 2003 Feb 15;50(3):437-50
17406264 - Nat Protoc. 2006;1(1):418-28
7584402 - Proc Int Conf Intell Syst Mol Biol. 1994;2:28-36
11455963 - RNA. 2001 Jul;7(7):937-41
26033498 - Proteins. 2015 Dec;83(12):2124-36
25837512 - Science. 2015 Apr 17;348(6232):303-8
18818215 - Bioinformatics. 2008 Dec 1;24(23):2780-1
16608846 - J Biol Chem. 2006 Jun 16;281(24):16305-13
12060744 - Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):7980-5
19651879 - Nucleic Acids Res. 2009 Sep;37(17):5859-67
22045337 - EMBO J. 2012 Jan 18;31(2):443-56
9660196 - Eur J Biochem. 1998 Jun 1;254(2):389-94
23149385 - EMBO J. 2013 Jan 9;32(1):9-29
23932204 - Curr Opin Microbiol. 2013 Oct;16(5):652-8
21854988 - Cell. 2011 Aug 19;146(4):645-58
21708121 - Biochim Biophys Acta. 2011 Sep;1807(9):1198-205
22729865 - Adv Exp Med Biol. 2012;748:341-57
8944766 - Eur J Biochem. 1996 Nov 1;241(3):779-86
20124702 - Acta Crystallogr D Biol Crystallogr. 2010 Feb;66(Pt 2):213-21
17210671 - Hum Mol Genet. 2007 Feb 15;16(4):431-44
11440830 - Free Radic Biol Med. 2001 Jul 15;31(2):181-90
23046553 - BMC Syst Biol. 2012;6 Suppl 1:S20
18536644 - Nat Protoc. 2008;3(6):965-76
19682572 - Biochim Biophys Acta. 2010 Jan;1802(1):100-10
19837698 - Hum Mol Genet. 2010 Jan 1;19(1):170-80
25088301 - Cell Metab. 2014 Aug 5;20(2):226-40
23151580 - Nature. 2012 Nov 15;491(7424):374-83
17135289 - Mol Biol Cell. 2007 Feb;18(2):523-35
22661577 - Nucleic Acids Res. 2012 Sep;40(16):8033-47
22724066 - Open Biol. 2012 May;2(5):120061
15743613 - Vision Res. 2005 May;45(11):1439-46
8988256 - Experientia. 1996 Dec 15;52(12):1130-5
11967628 - Psychopharmacology (Berl). 2002 Apr;161(1):32-7
22450032 - Biochim Biophys Acta. 2013 Feb;1833(2):286-94
T Fox (BFncomms11884_CR3) 1996; 52
TD Andrews (BFncomms11884_CR15) 2012; 2
C Dell'Agnello (BFncomms11884_CR27) 2007; 16
EA Del Bel (BFncomms11884_CR42) 2002; 161
B Ruzzenente (BFncomms11884_CR29) 2012; 31
L Nijtmans (BFncomms11884_CR16) 1998; 254
I Wittig (BFncomms11884_CR31) 2006; 1
A Amunts (BFncomms11884_CR5) 2015; 348
S Dimauro (BFncomms11884_CR13) 2012; 748
P Emsley (BFncomms11884_CR37) 2004; 60
S Duvezin-Caubet (BFncomms11884_CR21) 2006; 281
SC Lovell (BFncomms11884_CR39) 2003; 50
O Rackham (BFncomms11884_CR28) 2009; 37
TL Bailey (BFncomms11884_CR45) 1993; 2
PD Adams (BFncomms11884_CR35) 2010; 66
H McWilliam (BFncomms11884_CR44) 2013; 41
W Kabsch (BFncomms11884_CR34) 1993; 26
A Zambrano (BFncomms11884_CR2) 2007; 18
SB Vafai (BFncomms11884_CR8) 2012; 491
L Holm (BFncomms11884_CR17) 2008; 24
BFncomms11884_CR38
SMS Davies (BFncomms11884_CR32) 2001; 31
DH Shin (BFncomms11884_CR19) 2002; 99
TR Mercer (BFncomms11884_CR22) 2011; 146
ID Small (BFncomms11884_CR4) 2013; 16
F Distelmaier (BFncomms11884_CR11) 2012; 32
JM Herrmann (BFncomms11884_CR20) 2013; 1833
Y Zhang (BFncomms11884_CR25) 2012; 6
BM Hallberg (BFncomms11884_CR1) 2014; 20
T Chujo (BFncomms11884_CR23) 2012; 40
JJ Crawley (BFncomms11884_CR40) 1980; 13
DJ Coughlin (BFncomms11884_CR30) 2009; 6
BJ Greber (BFncomms11884_CR6) 2015; 348
MC Franklin (BFncomms11884_CR18) 2015; 83
A Perrakis (BFncomms11884_CR36) 2001; 57
W Weraarpachai (BFncomms11884_CR9) 2009; 41
H Yang (BFncomms11884_CR26) 2009; 19
JJ Abdeljalil (BFncomms11884_CR41) 2005; 45
A Rötig (BFncomms11884_CR7) 2011; 1807
A Kuznetsov (BFncomms11884_CR33) 2008; 3
T Jiang (BFncomms11884_CR24) 2001; 7
F Diaz (BFncomms11884_CR12) 2010; 1802
J Seeger (BFncomms11884_CR14) 2010; 20
DD Leigh (BFncomms11884_CR10) 1951; 14
M Claros (BFncomms11884_CR43) 1996; 241
References_xml – volume: 41
  start-page: 833
  year: 2009
  end-page: 837
  ident: CR9
  article-title: Mutation in TACO1, encoding a translational activator of COX I, results in cytochrome c oxidase deficiency and late-onset Leigh syndrome
  publication-title: Nat. Genet.
  doi: 10.1038/ng.390
  contributor:
    fullname: Weraarpachai
– volume: 50
  start-page: 437
  year: 2003
  end-page: 450
  ident: CR39
  article-title: Structure validation by C alpha geometry: phi,psi and C beta deviation
  publication-title: Proteins
  doi: 10.1002/prot.10286
  contributor:
    fullname: Lovell
– volume: 13
  start-page: 167
  year: 1980
  end-page: 170
  ident: CR40
  article-title: Preliminary report of a simple animal behavior model for the anxiolytic effects of benzodiazepines
  publication-title: Pharmacol. Biochem. Behavior
  doi: 10.1016/0091-3057(80)90067-2
  contributor:
    fullname: Goodwin
– volume: 60
  start-page: 2126
  year: 2004
  end-page: 2132
  ident: CR37
  article-title: Coot: model-building tools for molecular graphics
  publication-title: Acta Crystallogr. D Biol. Crystallogr.
  doi: 10.1107/S0907444904019158
  contributor:
    fullname: Cowtan
– volume: 281
  start-page: 16305
  year: 2006
  end-page: 16313
  ident: CR21
  article-title: A ‘petite obligate’ mutant of : functional mtDNA is lethal in cells lacking the delta subunit of mitochondrial F1-ATPase
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M513805200
  contributor:
    fullname: Duvezin-Caubet
– volume: 491
  start-page: 374
  year: 2012
  end-page: 383
  ident: CR8
  article-title: Mitochondrial disorders as windows into an ancient organelle
  publication-title: Nature
  doi: 10.1038/nature11707
  contributor:
    fullname: Mootha
– volume: 57
  start-page: 1445
  year: 2001
  end-page: 1450
  ident: CR36
  article-title: ARP/wARP and molecular replacement
  publication-title: Acta Crystallogr. D Biol. Crystallogr.
  doi: 10.1107/S0907444901014007
  contributor:
    fullname: Lamzin
– volume: 241
  start-page: 779
  year: 1996
  end-page: 786
  ident: CR43
  article-title: Computational method to predict mitochondrially imported proteins and their targeting sequences
  publication-title: Eur. J. Biochem.
  doi: 10.1111/j.1432-1033.1996.00779.x
  contributor:
    fullname: Vincens
– volume: 20
  start-page: 226
  year: 2014
  end-page: 240
  ident: CR1
  article-title: Making proteins in the powerhouse
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2014.07.001
  contributor:
    fullname: Larsson
– volume: 19
  start-page: 170
  year: 2009
  end-page: 180
  ident: CR26
  article-title: Analysis of mouse models of cytochrome c oxidase deficiency owing to mutations in Sco2
  publication-title: Hum. Mol. Genet.
  doi: 10.1093/hmg/ddp477
  contributor:
    fullname: Yang
– volume: 66
  start-page: 213
  year: 2010
  end-page: 221
  ident: CR35
  article-title: PHENIX: a comprehensive Python-based system for macromolecular structure solution
  publication-title: Acta Crystallogr. D Biol. Crystallogr.
  doi: 10.1107/S0907444909052925
  contributor:
    fullname: Adams
– volume: 146
  start-page: 645
  year: 2011
  end-page: 658
  ident: CR22
  article-title: The human mitochondrial transcriptome
  publication-title: Cell
  doi: 10.1016/j.cell.2011.06.051
  contributor:
    fullname: Mercer
– volume: 40
  start-page: 8033
  year: 2012
  end-page: 8047
  ident: CR23
  article-title: LRPPRC/SLIRP suppresses PNPase-mediated mRNA decay and promotes polyadenylation in human mitochondria
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gks506
  contributor:
    fullname: Chujo
– volume: 161
  start-page: 32
  year: 2002
  end-page: 37
  ident: CR42
  article-title: Motor effects of acute and chronic inhibition of nitric oxide synthesis in mice
  publication-title: Psychopharmacology
  doi: 10.1007/s00213-002-1009-2
  contributor:
    fullname: Nucci-da-Silva
– volume: 45
  start-page: 8
  year: 2005
  end-page: 8
  ident: CR41
  article-title: The optomotor response: a robust first-line visual screening method for mice
  publication-title: Vis. Res.
  doi: 10.1016/j.visres.2004.12.015
  contributor:
    fullname: Abdeljalil
– volume: 18
  start-page: 523
  year: 2007
  end-page: 535
  ident: CR2
  article-title: Aberrant translation of cytochrome c oxidase subunit 1 mRNA species in the absence of Mss51p in the yeast Saccharomyces cerevisiae
  publication-title: Mol. Biol. Cell
  doi: 10.1091/mbc.e06-09-0803
  contributor:
    fullname: Zambrano
– volume: 348
  start-page: 95
  year: 2015
  end-page: 98
  ident: CR5
  article-title: The structure of the human mitochondrial ribosome
  publication-title: Science
  doi: 10.1126/science.aaa1193
  contributor:
    fullname: Ramakrishnan
– volume: 26
  start-page: 795
  year: 1993
  end-page: 800
  ident: CR34
  article-title: Automatic processing of rotation diffraction data from crystals of initially unknown symmetry and cell constants
  publication-title: J. Appl. Crystallogr
  doi: 10.1107/S0021889893005588
  contributor:
    fullname: Kabsch
– volume: 24
  start-page: 2780
  year: 2008
  end-page: 2781
  ident: CR17
  article-title: Searching protein structure databases with DaliLite v.3
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btn507
  contributor:
    fullname: Schenkel
– volume: 99
  start-page: 7980
  year: 2002
  end-page: 7985
  ident: CR19
  article-title: Crystal structure of conserved hypothetical protein Aq1575 from
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.132241399
  contributor:
    fullname: Kim
– volume: 6
  start-page: 195
  year: 2009
  end-page: 202
  ident: CR30
  article-title: Prediction and verification of mouse tRNA gene families
  publication-title: RNA Biol.
  doi: 10.4161/rna.6.2.8050
  contributor:
    fullname: Engelke
– volume: 16
  start-page: 652
  year: 2013
  end-page: 658
  ident: CR4
  article-title: Organelle transcriptomes: products of a deconstructed genome
  publication-title: Curr. Opin. Microbiol.
  doi: 10.1016/j.mib.2013.07.011
  contributor:
    fullname: Filipovska
– volume: 1833
  start-page: 286
  year: 2013
  end-page: 294
  ident: CR20
  article-title: Control of protein synthesis in yeast mitochondria: The concept of translational activators
  publication-title: Biochim. Biophys. Acta
  doi: 10.1016/j.bbamcr.2012.03.007
  contributor:
    fullname: Bonnefoy
– volume: 1802
  start-page: 100
  year: 2010
  end-page: 110
  ident: CR12
  publication-title: Biochim Biophys Acta
  doi: 10.1016/j.bbadis.2009.07.013
  contributor:
    fullname: Diaz
– volume: 83
  start-page: 2124
  year: 2015
  end-page: 2136
  ident: CR18
  article-title: Structural genomics for drug design against the pathogen
  publication-title: Proteins
  doi: 10.1002/prot.24841
  contributor:
    fullname: Franklin
– volume: 37
  start-page: 5859
  year: 2009
  end-page: 5867
  ident: CR28
  article-title: Pentatricopeptide repeat domain protein 1 lowers the levels of mitochondrial leucine tRNAs in cells
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkp627
  contributor:
    fullname: Rackham
– volume: 748
  start-page: 341
  year: 2012
  end-page: 357
  ident: CR13
  article-title: The many clinical faces of cytochrome c oxidase deficiency
  publication-title: Adv. Exp. Med. Biol.
  doi: 10.1007/978-1-4614-3573-0_14
  contributor:
    fullname: Schon
– volume: 7
  start-page: 937
  year: 2001
  end-page: 941
  ident: CR24
  article-title: Protein-RNA interactions in the subunits of human nuclear RNase P
  publication-title: RNA
  doi: 10.1017/S1355838201010299
  contributor:
    fullname: Altman
– ident: CR38
– volume: 3
  start-page: 965
  year: 2008
  end-page: 976
  ident: CR33
  article-title: Analysis of mitochondrial function in permeabilized muscle fibers, tissues and cells
  publication-title: Nat. Protoc.
  doi: 10.1038/nprot.2008.61
  contributor:
    fullname: Kuznetsov
– volume: 20
  start-page: 720
  year: 2010
  end-page: 724
  ident: CR14
  article-title: Clinical and neuropathological findings in patients with TACO1 mutations
  publication-title: Neuromuscul. Disord.
  doi: 10.1016/j.nmd.2010.06.017
  contributor:
    fullname: Seeger
– volume: 348
  start-page: 303
  year: 2015
  end-page: 308
  ident: CR6
  article-title: The complete structure of the 55S mammalian mitochondrial ribosome
  publication-title: Science
  doi: 10.1126/science.aaa3872
  contributor:
    fullname: Greber
– volume: 16
  start-page: 431
  year: 2007
  end-page: 444
  ident: CR27
  article-title: Increased longevity and refractoriness to Ca2+-dependent neurodegeneration in Surf1 knockout mice
  publication-title: Hum. Mol. Genet.
  doi: 10.1093/hmg/ddl477
  contributor:
    fullname: Dell'Agnello
– volume: 254
  start-page: 389
  year: 1998
  end-page: 394
  ident: CR16
  article-title: Assembly of cytochrome-c oxidase in cultured human cells
  publication-title: Eur. J. Biochem.
  doi: 10.1046/j.1432-1327.1998.2540389.x
  contributor:
    fullname: Van den Bogert
– volume: 1
  start-page: 418
  year: 2006
  end-page: 428
  ident: CR31
  article-title: Blue native PAGE
  publication-title: Nat. Protoc.
  doi: 10.1038/nprot.2006.62
  contributor:
    fullname: Schägger
– volume: 2
  start-page: 120061
  year: 2012
  ident: CR15
  article-title: Massively parallel sequencing of the mouse exome to accurately identify rare, induced mutations: an immediate source for thousands of new mouse models
  publication-title: Open Biol.
  doi: 10.1098/rsob.120061
  contributor:
    fullname: Andrews
– volume: 2
  start-page: 28
  year: 1993
  end-page: 36
  ident: CR45
  article-title: Fitting a mixture model by expectation maximization to discover motifs in biopolymers
  publication-title: Proc. Int. Conf. Intell. Syst. Mol. Biol.
  contributor:
    fullname: Elkan
– volume: 6
  start-page: S20
  year: 2012
  end-page: S20
  ident: CR25
  article-title: identification of a multi-functional regulatory protein involved in Holliday junction resolution in bacteria
  publication-title: BMC Syst. Biol.
  doi: 10.1186/1752-0509-6-S1-S20
  contributor:
    fullname: Gao
– volume: 41
  start-page: W597
  year: 2013
  end-page: W600
  ident: CR44
  article-title: Analysis tool web services from the EMBL-EBI
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkt376
  contributor:
    fullname: McWilliam
– volume: 31
  start-page: 443
  year: 2012
  end-page: 456
  ident: CR29
  article-title: LRPPRC is necessary for polyadenylation and coordination of translation of mitochondrial mRNAs
  publication-title: EMBO J.
  doi: 10.1038/emboj.2011.392
  contributor:
    fullname: Ruzzenente
– volume: 52
  start-page: 1130
  year: 1996
  end-page: 1135
  ident: CR3
  article-title: Translational control of endogenous and recoded nuclear genes in yeast mitochondria: regulation and membrane targeting
  publication-title: Experientia
  doi: 10.1007/BF01952112
  contributor:
    fullname: Fox
– volume: 32
  start-page: 9
  year: 2012
  end-page: 29
  ident: CR11
  article-title: OXPHOS mutations and neurodegeneration
  publication-title: EMBO J.
  doi: 10.1038/emboj.2012.300
  contributor:
    fullname: Koopman
– volume: 14
  start-page: 216
  year: 1951
  end-page: 221
  ident: CR10
  article-title: Subacute necrotizing encephalomyelopathy in an infant
  publication-title: J. Neurol. Neurosurg. Psychiatry
  doi: 10.1136/jnnp.14.3.216
  contributor:
    fullname: Leigh
– volume: 1807
  start-page: 1198
  year: 2011
  end-page: 1205
  ident: CR7
  article-title: Human diseases with impaired mitochondrial protein synthesis
  publication-title: Biochim. Biophys. Acta
  doi: 10.1016/j.bbabio.2011.06.010
  contributor:
    fullname: Rötig
– volume: 31
  start-page: 181
  year: 2001
  end-page: 190
  ident: CR32
  article-title: Measurements of protein carbonyls, ortho- and meta-tyrosine and oxidative phosphorylation complex activity in mitochondria from young and old rats
  publication-title: Free Rad. Biol. Med.
  doi: 10.1016/S0891-5849(01)00576-7
  contributor:
    fullname: Murphy
– volume: 254
  start-page: 389
  year: 1998
  ident: BFncomms11884_CR16
  publication-title: Eur. J. Biochem.
  doi: 10.1046/j.1432-1327.1998.2540389.x
  contributor:
    fullname: L Nijtmans
– volume: 37
  start-page: 5859
  year: 2009
  ident: BFncomms11884_CR28
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkp627
  contributor:
    fullname: O Rackham
– volume: 60
  start-page: 2126
  year: 2004
  ident: BFncomms11884_CR37
  publication-title: Acta Crystallogr. D Biol. Crystallogr.
  doi: 10.1107/S0907444904019158
  contributor:
    fullname: P Emsley
– volume: 16
  start-page: 652
  year: 2013
  ident: BFncomms11884_CR4
  publication-title: Curr. Opin. Microbiol.
  doi: 10.1016/j.mib.2013.07.011
  contributor:
    fullname: ID Small
– volume: 19
  start-page: 170
  year: 2009
  ident: BFncomms11884_CR26
  publication-title: Hum. Mol. Genet.
  doi: 10.1093/hmg/ddp477
  contributor:
    fullname: H Yang
– ident: BFncomms11884_CR38
– volume: 20
  start-page: 226
  year: 2014
  ident: BFncomms11884_CR1
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2014.07.001
  contributor:
    fullname: BM Hallberg
– volume: 7
  start-page: 937
  year: 2001
  ident: BFncomms11884_CR24
  publication-title: RNA
  doi: 10.1017/S1355838201010299
  contributor:
    fullname: T Jiang
– volume: 348
  start-page: 95
  year: 2015
  ident: BFncomms11884_CR5
  publication-title: Science
  doi: 10.1126/science.aaa1193
  contributor:
    fullname: A Amunts
– volume: 146
  start-page: 645
  year: 2011
  ident: BFncomms11884_CR22
  publication-title: Cell
  doi: 10.1016/j.cell.2011.06.051
  contributor:
    fullname: TR Mercer
– volume: 45
  start-page: 8
  year: 2005
  ident: BFncomms11884_CR41
  publication-title: Vis. Res.
  doi: 10.1016/j.visres.2004.12.015
  contributor:
    fullname: JJ Abdeljalil
– volume: 32
  start-page: 9
  year: 2012
  ident: BFncomms11884_CR11
  publication-title: EMBO J.
  doi: 10.1038/emboj.2012.300
  contributor:
    fullname: F Distelmaier
– volume: 31
  start-page: 443
  year: 2012
  ident: BFncomms11884_CR29
  publication-title: EMBO J.
  doi: 10.1038/emboj.2011.392
  contributor:
    fullname: B Ruzzenente
– volume: 66
  start-page: 213
  year: 2010
  ident: BFncomms11884_CR35
  publication-title: Acta Crystallogr. D Biol. Crystallogr.
  doi: 10.1107/S0907444909052925
  contributor:
    fullname: PD Adams
– volume: 748
  start-page: 341
  year: 2012
  ident: BFncomms11884_CR13
  publication-title: Adv. Exp. Med. Biol.
  doi: 10.1007/978-1-4614-3573-0_14
  contributor:
    fullname: S Dimauro
– volume: 99
  start-page: 7980
  year: 2002
  ident: BFncomms11884_CR19
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.132241399
  contributor:
    fullname: DH Shin
– volume: 241
  start-page: 779
  year: 1996
  ident: BFncomms11884_CR43
  publication-title: Eur. J. Biochem.
  doi: 10.1111/j.1432-1033.1996.00779.x
  contributor:
    fullname: M Claros
– volume: 41
  start-page: W597
  year: 2013
  ident: BFncomms11884_CR44
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkt376
  contributor:
    fullname: H McWilliam
– volume: 41
  start-page: 833
  year: 2009
  ident: BFncomms11884_CR9
  publication-title: Nat. Genet.
  doi: 10.1038/ng.390
  contributor:
    fullname: W Weraarpachai
– volume: 57
  start-page: 1445
  year: 2001
  ident: BFncomms11884_CR36
  publication-title: Acta Crystallogr. D Biol. Crystallogr.
  doi: 10.1107/S0907444901014007
  contributor:
    fullname: A Perrakis
– volume: 40
  start-page: 8033
  year: 2012
  ident: BFncomms11884_CR23
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gks506
  contributor:
    fullname: T Chujo
– volume: 6
  start-page: S20
  year: 2012
  ident: BFncomms11884_CR25
  publication-title: BMC Syst. Biol.
  doi: 10.1186/1752-0509-6-S1-S20
  contributor:
    fullname: Y Zhang
– volume: 1802
  start-page: 100
  year: 2010
  ident: BFncomms11884_CR12
  publication-title: Biochim Biophys Acta
  doi: 10.1016/j.bbadis.2009.07.013
  contributor:
    fullname: F Diaz
– volume: 281
  start-page: 16305
  year: 2006
  ident: BFncomms11884_CR21
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M513805200
  contributor:
    fullname: S Duvezin-Caubet
– volume: 491
  start-page: 374
  year: 2012
  ident: BFncomms11884_CR8
  publication-title: Nature
  doi: 10.1038/nature11707
  contributor:
    fullname: SB Vafai
– volume: 2
  start-page: 120061
  year: 2012
  ident: BFncomms11884_CR15
  publication-title: Open Biol.
  doi: 10.1098/rsob.120061
  contributor:
    fullname: TD Andrews
– volume: 50
  start-page: 437
  year: 2003
  ident: BFncomms11884_CR39
  publication-title: Proteins
  doi: 10.1002/prot.10286
  contributor:
    fullname: SC Lovell
– volume: 20
  start-page: 720
  year: 2010
  ident: BFncomms11884_CR14
  publication-title: Neuromuscul. Disord.
  doi: 10.1016/j.nmd.2010.06.017
  contributor:
    fullname: J Seeger
– volume: 1
  start-page: 418
  year: 2006
  ident: BFncomms11884_CR31
  publication-title: Nat. Protoc.
  doi: 10.1038/nprot.2006.62
  contributor:
    fullname: I Wittig
– volume: 18
  start-page: 523
  year: 2007
  ident: BFncomms11884_CR2
  publication-title: Mol. Biol. Cell
  doi: 10.1091/mbc.e06-09-0803
  contributor:
    fullname: A Zambrano
– volume: 2
  start-page: 28
  year: 1993
  ident: BFncomms11884_CR45
  publication-title: Proc. Int. Conf. Intell. Syst. Mol. Biol.
  contributor:
    fullname: TL Bailey
– volume: 1833
  start-page: 286
  year: 2013
  ident: BFncomms11884_CR20
  publication-title: Biochim. Biophys. Acta
  doi: 10.1016/j.bbamcr.2012.03.007
  contributor:
    fullname: JM Herrmann
– volume: 161
  start-page: 32
  year: 2002
  ident: BFncomms11884_CR42
  publication-title: Psychopharmacology
  doi: 10.1007/s00213-002-1009-2
  contributor:
    fullname: EA Del Bel
– volume: 3
  start-page: 965
  year: 2008
  ident: BFncomms11884_CR33
  publication-title: Nat. Protoc.
  doi: 10.1038/nprot.2008.61
  contributor:
    fullname: A Kuznetsov
– volume: 1807
  start-page: 1198
  year: 2011
  ident: BFncomms11884_CR7
  publication-title: Biochim. Biophys. Acta
  doi: 10.1016/j.bbabio.2011.06.010
  contributor:
    fullname: A Rötig
– volume: 6
  start-page: 195
  year: 2009
  ident: BFncomms11884_CR30
  publication-title: RNA Biol.
  doi: 10.4161/rna.6.2.8050
  contributor:
    fullname: DJ Coughlin
– volume: 13
  start-page: 167
  year: 1980
  ident: BFncomms11884_CR40
  publication-title: Pharmacol. Biochem. Behavior
  doi: 10.1016/0091-3057(80)90067-2
  contributor:
    fullname: JJ Crawley
– volume: 26
  start-page: 795
  year: 1993
  ident: BFncomms11884_CR34
  publication-title: J. Appl. Crystallogr
  doi: 10.1107/S0021889893005588
  contributor:
    fullname: W Kabsch
– volume: 348
  start-page: 303
  year: 2015
  ident: BFncomms11884_CR6
  publication-title: Science
  doi: 10.1126/science.aaa3872
  contributor:
    fullname: BJ Greber
– volume: 83
  start-page: 2124
  year: 2015
  ident: BFncomms11884_CR18
  publication-title: Proteins
  doi: 10.1002/prot.24841
  contributor:
    fullname: MC Franklin
– volume: 16
  start-page: 431
  year: 2007
  ident: BFncomms11884_CR27
  publication-title: Hum. Mol. Genet.
  doi: 10.1093/hmg/ddl477
  contributor:
    fullname: C Dell'Agnello
– volume: 14
  start-page: 216
  year: 1951
  ident: BFncomms11884_CR10
  publication-title: J. Neurol. Neurosurg. Psychiatry
  doi: 10.1136/jnnp.14.3.216
  contributor:
    fullname: DD Leigh
– volume: 31
  start-page: 181
  year: 2001
  ident: BFncomms11884_CR32
  publication-title: Free Rad. Biol. Med.
  doi: 10.1016/S0891-5849(01)00576-7
  contributor:
    fullname: SMS Davies
– volume: 24
  start-page: 2780
  year: 2008
  ident: BFncomms11884_CR17
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btn507
  contributor:
    fullname: L Holm
– volume: 52
  start-page: 1130
  year: 1996
  ident: BFncomms11884_CR3
  publication-title: Experientia
  doi: 10.1007/BF01952112
  contributor:
    fullname: T Fox
SSID ssj0000391844
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Snippet The recognition and translation of mammalian mitochondrial mRNAs are poorly understood. To gain further insights into these processes in vivo, we characterized...
The recognition and translation of mammalian mitochondrial mRNAs are poorly understood. To gain further insights into these processes in vivo, we characterized...
Mutations in the translational activator of cytochrome c oxidase subunit I (TACO1) causes cytochrome c oxidase deficiency and Leigh Syndrome in patients. Here,...
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StartPage 11884
SubjectTerms 631/337/574/1789
631/45/612/1230
64/60
692/699
Amino Acid Sequence
Animals
Binding Sites
Biochemistry
Biology
Cardiomegaly - genetics
Cardiomegaly - metabolism
Cardiomegaly - pathology
Cloning, Molecular
Crystallography, X-Ray
Cytochrome
Dystonia
Escherichia coli - genetics
Escherichia coli - metabolism
Genes
Genomes
Heart
Humanities and Social Sciences
Male
Medical research
Medicin och hälsovetenskap
Metabolism
Mice
Mice, Knockout
Microfilament Proteins - chemistry
Microfilament Proteins - genetics
Microfilament Proteins - metabolism
Mitochondria
Mitochondria - metabolism
Mitochondria - pathology
Mitochondrial Diseases - genetics
Mitochondrial Diseases - metabolism
Mitochondrial Diseases - pathology
Mitochondrial Proteins - chemistry
Mitochondrial Proteins - genetics
Mitochondrial Proteins - metabolism
Models, Molecular
multidisciplinary
Mutation
Protein Binding
Protein Biosynthesis
Protein Conformation, alpha-Helical
Protein Conformation, beta-Strand
Protein Interaction Domains and Motifs
Proteins
Recombinant Proteins - chemistry
Recombinant Proteins - genetics
Recombinant Proteins - metabolism
Ribonucleic acid
RNA
RNA, Messenger - chemistry
RNA, Messenger - metabolism
Science
Science (multidisciplinary)
Sequence Alignment
Sequence Homology, Amino Acid
Visual impairment
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Title Loss of the RNA-binding protein TACO1 causes late-onset mitochondrial dysfunction in mice
URI https://link.springer.com/article/10.1038/ncomms11884
https://www.ncbi.nlm.nih.gov/pubmed/27319982
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https://pubmed.ncbi.nlm.nih.gov/PMC4915168
http://kipublications.ki.se/Default.aspx?queryparsed=id:133874843
https://doaj.org/article/7c8e652660f64c7ba9ff15b23fd6d83c
Volume 7
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