Preoperative platelet aggregation predicts perioperative blood loss and rethoracotomy for bleeding in patients receiving dual antiplatelet treatment prior to coronary surgery

• Published in: Thrombosis research Vol. 136; no. 3; pp. 519 - 525
• Main Authors: Plicner, Dariusz, Mazur, Piotr, Hymczak, Hubert, Stoliński, Jarosław, Litwinowicz, Radosław, Drwiła, Rafał, Undas, Anetta
• Format: Journal Article
• Language: English
• Published: United States Elsevier Ltd 01.09.2015
• Subjects: Aspirin - administration & dosage; Aspirin - adverse effects; Bleeding; Blood Loss, Surgical - prevention & control; CABG; Clopidogrel; Coronary Artery Bypass - adverse effects; Coronary artery bypass grafting; Drug Combinations; Female; Hematology, Oncology and Palliative Medicine; Humans; Male; Platelet aggregation; Platelet Aggregation - drug effects; Platelet Aggregation Inhibitors - administration & dosage; Platelet Aggregation Inhibitors - adverse effects; Platelet Function Tests - methods; Postoperative Hemorrhage - chemically induced; Postoperative Hemorrhage - diagnosis; Postoperative Hemorrhage - prevention & control; Premedication - adverse effects; Prognosis; Reoperation; Reproducibility of Results; Sensitivity and Specificity; Thoracic Surgery; Thrombosis - prevention & control; Ticlopidine - administration & dosage; Ticlopidine - adverse effects; Ticlopidine - analogs & derivatives; Transfusions; Treatment Outcome; PRBC; CK-MB; Transfusions; Platelet aggregation; INR; ADP; PMI; Bleeding; APTT; FFP; STS; CPB; Coronary artery bypass grafting; PCI; HPA; LTA; Clopidogrel; Hb; CABG; LPA; MI; DAPT; BMI; light transmission aggregometry; myocardial infarction; international normalized ratio; hemoglobin; dual antiplatelet therapy; fresh frozen plasma; percutaneous coronary intervention; creatine kinase MB fraction; cardiopulmonary bypass; Society of Thoracic Surgeons; adenosine di-phosphate; body mass index; low platelet aggregation; packed red blood cells; activated partial thromboplastin time; high platelet aggregation; perioperative myocardial infarction

Patients scheduled for coronary artery bypass graft surgery (CABG) are commonly treated with clopidogrel. We sought to assess the relation between preoperative platelet aggregation and bleeds in CABG patients on clopidogrel. In a case-control study, we compared 52 consecutive patients undergoing iso...