Efficient Activation of the Severe Acute Respiratory Syndrome Coronavirus Spike Protein by the Transmembrane Protease TMPRSS2
Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue Spotlights in the Current Issue JVI About JVI Subscribers Authors Reviewers Advertisers Inquiries from...
Saved in:
| Published in | Journal of Virology Vol. 84; no. 24; pp. 12658 - 12664 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Washington, DC
American Society for Microbiology
01.12.2010
American Society for Microbiology (ASM) |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Article Usage Stats
Services
JVI
Citing Articles
Google Scholar
PubMed
Related Content
Social Bookmarking
CiteULike
Delicious
Digg
Facebook
Google+
Mendeley
Reddit
StumbleUpon
Twitter
current issue
Spotlights in the Current Issue
JVI
About
JVI
Subscribers
Authors
Reviewers
Advertisers
Inquiries from the Press
Permissions & Commercial Reprints
ASM Journals Public Access Policy
JVI
RSS Feeds
1752 N Street N.W. • Washington DC 20036
202.737.3600 • 202.942.9355 fax • journals@asmusa.org
Print ISSN:
0022-538X
Online ISSN:
1098-5514
Copyright © 2014
by the
American Society for Microbiology.
For an alternate route to
JVI
.asm.org, visit:
JVI
|
|---|---|
| AbstractList | The distribution of the severe acute respiratory syndrome coronavirus (SARS-CoV) receptor, an angiotensin-converting enzyme 2 (ACE2), does not strictly correlate with SARS-CoV cell tropism in lungs; therefore, other cellular factors have been predicted to be required for activation of virus infection. In the present study, we identified transmembrane protease serine 2 (TMPRSS2), whose expression does correlate with SARS-CoV infection in the upper lobe of the lung. In Vero cells expressing TMPRSS2, large syncytia were induced by SARS-CoV infection. Further, the lysosome-tropic reagents failed to inhibit, whereas the heptad repeat peptide efficiently inhibited viral entry into cells, suggesting that TMPRSS2 affects the S protein at the cell surface and induces virus-plasma membrane fusion. On the other hand, production of virus in TMPRSS2-expressing cells did not result in S-protein cleavage or increased infectivity of the resulting virus. Thus, TMPRSS2 affects the entry of virus but not other phases of virus replication. We hypothesized that the spatial orientation of TMPRSS2 vis-a-vis S protein is a key mechanism underling this phenomenon. To test this, the TMPRSS2 and S proteins were expressed in cells labeled with fluorescent probes of different colors, and the cell-cell fusion between these cells was tested. Results indicate that TMPRSS2 needs to be expressed in the opposing (target) cell membrane to activate S protein rather than in the producer cell, as found for influenza A virus and metapneumoviruses. This is the first report of TMPRSS2 being required in the target cell for activation of a viral fusion protein but not for the S protein synthesized in and transported to the surface of cells. Our findings suggest that the TMPRSS2 expressed in lung tissues may be a determinant of viral tropism and pathogenicity at the initial site of SARS-CoV infection. Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue Spotlights in the Current Issue JVI About JVI Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy JVI RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0022-538X Online ISSN: 1098-5514 Copyright © 2014 by the American Society for Microbiology. For an alternate route to JVI .asm.org, visit: JVI The distribution of the severe acute respiratory syndrome coronavirus (SARS-CoV) receptor, an angiotensin-converting enzyme 2 (ACE2), does not strictly correlate with SARS-CoV cell tropism in lungs; therefore, other cellular factors have been predicted to be required for activation of virus infection. In the present study, we identified transmembrane protease serine 2 (TMPRSS2), whose expression does correlate with SARS-CoV infection in the upper lobe of the lung. In Vero cells expressing TMPRSS2, large syncytia were induced by SARS-CoV infection. Further, the lysosome-tropic reagents failed to inhibit, whereas the heptad repeat peptide efficiently inhibited viral entry into cells, suggesting that TMPRSS2 affects the S protein at the cell surface and induces virus-plasma membrane fusion. On the other hand, production of virus in TMPRSS2-expressing cells did not result in S-protein cleavage or increased infectivity of the resulting virus. Thus, TMPRSS2 affects the entry of virus but not other phases of virus replication. We hypothesized that the spatial orientation of TMPRSS2 vis-a-vis S protein is a key mechanism underling this phenomenon. To test this, the TMPRSS2 and S proteins were expressed in cells labeled with fluorescent probes of different colors, and the cell-cell fusion between these cells was tested. Results indicate that TMPRSS2 needs to be expressed in the opposing (target) cell membrane to activate S protein rather than in the producer cell, as found for influenza A virus and metapneumoviruses. This is the first report of TMPRSS2 being required in the target cell for activation of a viral fusion protein but not for the S protein synthesized in and transported to the surface of cells. Our findings suggest that the TMPRSS2 expressed in lung tissues may be a determinant of viral tropism and pathogenicity at the initial site of SARS-CoV infection.The distribution of the severe acute respiratory syndrome coronavirus (SARS-CoV) receptor, an angiotensin-converting enzyme 2 (ACE2), does not strictly correlate with SARS-CoV cell tropism in lungs; therefore, other cellular factors have been predicted to be required for activation of virus infection. In the present study, we identified transmembrane protease serine 2 (TMPRSS2), whose expression does correlate with SARS-CoV infection in the upper lobe of the lung. In Vero cells expressing TMPRSS2, large syncytia were induced by SARS-CoV infection. Further, the lysosome-tropic reagents failed to inhibit, whereas the heptad repeat peptide efficiently inhibited viral entry into cells, suggesting that TMPRSS2 affects the S protein at the cell surface and induces virus-plasma membrane fusion. On the other hand, production of virus in TMPRSS2-expressing cells did not result in S-protein cleavage or increased infectivity of the resulting virus. Thus, TMPRSS2 affects the entry of virus but not other phases of virus replication. We hypothesized that the spatial orientation of TMPRSS2 vis-a-vis S protein is a key mechanism underling this phenomenon. To test this, the TMPRSS2 and S proteins were expressed in cells labeled with fluorescent probes of different colors, and the cell-cell fusion between these cells was tested. Results indicate that TMPRSS2 needs to be expressed in the opposing (target) cell membrane to activate S protein rather than in the producer cell, as found for influenza A virus and metapneumoviruses. This is the first report of TMPRSS2 being required in the target cell for activation of a viral fusion protein but not for the S protein synthesized in and transported to the surface of cells. Our findings suggest that the TMPRSS2 expressed in lung tissues may be a determinant of viral tropism and pathogenicity at the initial site of SARS-CoV infection. |
| Author | Noriyo Nagata Miyuki Kawase Makoto Takeda Shutoku Matsuyama Fumihiro Taguchi Kazuya Shirato |
| AuthorAffiliation | Departments of Virology III, 1 Pathology, National Institute of Infectious Diseases, Japan, 4-7-1 Gakuen Musashi-Murayama, Tokyo 208-0011, Japan, 2 Faculty of Veterinary Medicine, Nippon Veterinary and Life Science University, 1-7-1 Sakai-minami Musasino, Tokyo 180-8602, Japan 3 |
| AuthorAffiliation_xml | – name: Departments of Virology III, 1 Pathology, National Institute of Infectious Diseases, Japan, 4-7-1 Gakuen Musashi-Murayama, Tokyo 208-0011, Japan, 2 Faculty of Veterinary Medicine, Nippon Veterinary and Life Science University, 1-7-1 Sakai-minami Musasino, Tokyo 180-8602, Japan 3 |
| Author_xml | – sequence: 1 givenname: Shutoku surname: Matsuyama fullname: Matsuyama, Shutoku organization: Departments of Virology III – sequence: 2 givenname: Noriyo surname: Nagata fullname: Nagata, Noriyo organization: Pathology, National Institute of Infectious Diseases, Japan, 4-7-1 Gakuen Musashi-Murayama, Tokyo 208-0011, Japan – sequence: 3 givenname: Kazuya surname: Shirato fullname: Shirato, Kazuya organization: Departments of Virology III – sequence: 4 givenname: Miyuki surname: Kawase fullname: Kawase, Miyuki organization: Departments of Virology III – sequence: 5 givenname: Makoto surname: Takeda fullname: Takeda, Makoto organization: Departments of Virology III – sequence: 6 givenname: Fumihiro surname: Taguchi fullname: Taguchi, Fumihiro organization: Faculty of Veterinary Medicine, Nippon Veterinary and Life Science University, 1-7-1 Sakai-minami Musasino, Tokyo 180-8602, Japan |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23530073$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/20926566$$D View this record in MEDLINE/PubMed |
| BookMark | eNqNks1v1DAQxS1URLeFG2dkCSEupPgrifeCVK1aKCqiagriZjnOpOuSxIvtpNoD_ztmdykfElJPlub95unNeA7Q3uAGQOgpJUeUMvn6_eezI0JzwTJKHqAZJXOZ5TkVe2hGCGNZzuWXfXQQwg0hVIhCPEL7jMxZkRfFDH0_aVtrLAwRH5toJx2tG7BrcVwCrmACD0kYI-BLCCvrdXR-jav10HjXA1447wY9WT8GXK3sV8AX3kWwA67XG4srr4fQQ1-ndyfqkMofLi6rij1GD1vdBXiyew_Rp9OTq8W77Pzj27PF8XlmiqKIGZNpEAGcQd5y0paSN5rWshS0hjmthWlLxqBsiGFMiloaSU1ByrphRiex5YfozdZ3NdY9NCaN63WnVt722q-V01b9rQx2qa7dpDghguc0GbzcGXj3bYQQVW-Dga5LU7kxKFkQXhYsJbsXKeb0HiRllCdLkshnf8a_y_3rGxPwYgfoYHTXpmUbG35zPE-DlDxxr7ac8S4ED-0dQon6eU0qXZPaXFOqJJz9gxsbNxeSlmS7_zU93zYt7fXy1npQOvTqZrJKCsWEoimy5D8A1W3ZZA |
| CitedBy_id | crossref_primary_10_3389_fmed_2020_589409 crossref_primary_10_1371_journal_pone_0271303 crossref_primary_10_1371_journal_ppat_1010340 crossref_primary_10_1016_j_progpolymsci_2021_101410 crossref_primary_10_3390_v13071292 crossref_primary_10_1016_j_retram_2022_103333 crossref_primary_10_1038_s41579_020_00468_6 crossref_primary_10_1016_j_virol_2017_12_015 crossref_primary_10_1016_j_mam_2021_100996 crossref_primary_10_1007_s12015_021_10214_x crossref_primary_10_3389_fped_2021_617980 crossref_primary_10_1016_j_cbi_2021_109583 crossref_primary_10_1016_j_cell_2020_05_042 crossref_primary_10_1073_pnas_2002589117 crossref_primary_10_1016_j_ijbiomac_2024_129523 crossref_primary_10_1038_s12276_024_01283_2 crossref_primary_10_3390_cells13030203 crossref_primary_10_35229_jaes_1062753 crossref_primary_10_3389_fcvm_2021_619690 crossref_primary_10_1080_17476348_2021_1823833 crossref_primary_10_3389_fimmu_2020_01606 crossref_primary_10_3390_cells10061469 crossref_primary_10_2174_1566524021666211117145216 crossref_primary_10_3389_fimmu_2020_01841 crossref_primary_10_1097_CCM_0000000000004895 crossref_primary_10_15252_embj_2020106267 crossref_primary_10_3390_pharmaceutics14010176 crossref_primary_10_3390_v16111798 crossref_primary_10_2174_1389450121999201125201112 crossref_primary_10_1007_s40618_020_01486_0 crossref_primary_10_1016_j_molliq_2022_119795 crossref_primary_10_1128_jvi_00851_23 crossref_primary_10_1371_journal_ppat_1009212 crossref_primary_10_1038_s41392_021_00733_x crossref_primary_10_1177_09727531211023755 crossref_primary_10_3390_v14112557 crossref_primary_10_1080_08923973_2020_1842444 crossref_primary_10_3389_fcimb_2025_1513687 crossref_primary_10_1016_j_advms_2023_10_010 crossref_primary_10_1016_j_imbio_2020_152008 crossref_primary_10_1208_s12248_021_00666_x crossref_primary_10_1038_s41598_021_82956_0 crossref_primary_10_1016_j_bmc_2025_118135 crossref_primary_10_1371_journal_pone_0214968 crossref_primary_10_3389_fpls_2020_601335 crossref_primary_10_3389_fcell_2023_1290876 crossref_primary_10_3390_v10120721 crossref_primary_10_1016_j_virusres_2021_198423 crossref_primary_10_1016_j_antiviral_2013_09_028 crossref_primary_10_1097_COH_0000000000000658 crossref_primary_10_1007_s12035_021_02399_6 crossref_primary_10_1128_JVI_00543_15 crossref_primary_10_3390_biomedicines9091142 crossref_primary_10_1007_s15010_024_02293_y crossref_primary_10_1007_s12010_022_03885_w crossref_primary_10_1016_j_heliyon_2021_e07665 crossref_primary_10_1016_j_isci_2022_104759 crossref_primary_10_3389_fphys_2020_00820 crossref_primary_10_1021_acsinfecdis_2c00416 crossref_primary_10_3390_biomedicines8110462 crossref_primary_10_54097_hset_v36i_5674 crossref_primary_10_1128_jvi_01650_22 crossref_primary_10_1128_JVI_01890_13 crossref_primary_10_1371_journal_ppat_1011870 crossref_primary_10_1016_j_omtm_2020_05_013 crossref_primary_10_1039_D1SC01494C crossref_primary_10_1016_j_ymeth_2021_12_003 crossref_primary_10_1186_s12931_017_0567_0 crossref_primary_10_1371_journal_pone_0176597 crossref_primary_10_1016_j_cell_2020_04_035 crossref_primary_10_1016_j_aquaculture_2021_736460 crossref_primary_10_1007_s12038_020_00067_w crossref_primary_10_1128_JVI_00128_13 crossref_primary_10_3389_fgwh_2021_602572 crossref_primary_10_2222_jsv_70_155 crossref_primary_10_1080_10408363_2020_1776675 crossref_primary_10_1016_j_jtcvs_2020_05_083 crossref_primary_10_1128_spectrum_02381_22 crossref_primary_10_1007_s11739_023_03316_6 crossref_primary_10_1016_j_ejps_2020_105495 crossref_primary_10_1002_prot_26548 crossref_primary_10_1016_j_virusres_2020_198141 crossref_primary_10_1128_JVI_00464_11 crossref_primary_10_1080_17460441_2022_2029843 crossref_primary_10_1016_j_crmicr_2020_06_003 crossref_primary_10_1016_j_hjc_2020_05_007 crossref_primary_10_1021_acsinfecdis_0c00343 crossref_primary_10_1128_JVI_00140_21 crossref_primary_10_2222_jsv_69_61 crossref_primary_10_1016_j_pathol_2020_08_001 crossref_primary_10_3390_ijms21165707 crossref_primary_10_1038_s41598_020_74050_8 crossref_primary_10_1038_s41564_020_0688_y crossref_primary_10_1128_AAC_01581_21 crossref_primary_10_1128_CMR_00133_20 crossref_primary_10_1016_j_vacun_2023_04_003 crossref_primary_10_1080_07391102_2020_1777901 crossref_primary_10_3390_ijms22168663 crossref_primary_10_3390_vaccines9040389 crossref_primary_10_1172_JCI140766 crossref_primary_10_1128_JVI_00861_21 crossref_primary_10_3390_ijms22168660 crossref_primary_10_2174_1381612828666220506142117 crossref_primary_10_1016_j_mehy_2020_110082 crossref_primary_10_3389_fphar_2022_953438 crossref_primary_10_1016_j_ebiom_2020_103104 crossref_primary_10_3390_cells11193027 crossref_primary_10_1016_j_xcrm_2020_100142 crossref_primary_10_1183_23120541_00405_2020 crossref_primary_10_4014_jmb_2206_06064 crossref_primary_10_1038_s41598_021_84850_1 crossref_primary_10_1080_13543776_2017_1272572 crossref_primary_10_2174_1874467214666210811120635 crossref_primary_10_1016_j_bcp_2020_114225 crossref_primary_10_1128_spectrum_02859_23 crossref_primary_10_1016_j_meegid_2020_104498 crossref_primary_10_1073_pnas_1608147113 crossref_primary_10_15283_ijsc21251 crossref_primary_10_1371_journal_pone_0235106 crossref_primary_10_2174_1566524021666210803154250 crossref_primary_10_1016_j_placenta_2021_01_008 crossref_primary_10_1111_andr_12804 crossref_primary_10_1128_JVI_03005_12 crossref_primary_10_1177_0963689720968749 crossref_primary_10_1016_j_chom_2022_01_006 crossref_primary_10_1128_jvi_00128_22 crossref_primary_10_1007_s00109_022_02182_7 crossref_primary_10_1146_annurev_biophys_102620_080956 crossref_primary_10_1016_j_virusres_2020_198275 crossref_primary_10_1038_s41467_020_19808_4 crossref_primary_10_1371_journal_pone_0076469 crossref_primary_10_3390_cells9071583 crossref_primary_10_1128_JVI_02232_10 crossref_primary_10_1016_j_bmc_2020_115757 crossref_primary_10_3390_brainsci10100666 crossref_primary_10_1016_j_cytogfr_2020_05_001 crossref_primary_10_3390_ijms24043288 crossref_primary_10_3389_fmicb_2023_1188249 crossref_primary_10_1128_msystems_00095_21 crossref_primary_10_3390_v14050849 crossref_primary_10_1371_journal_pbio_3001143 crossref_primary_10_1021_acs_jpclett_0c02602 crossref_primary_10_1016_j_cmi_2022_05_020 crossref_primary_10_1021_acsptsci_0c00109 crossref_primary_10_1016_j_carbpol_2024_122605 crossref_primary_10_36485_1561_6274_2021_25_2_18_26 crossref_primary_10_1128_JVI_03050_13 crossref_primary_10_1021_acsinfecdis_3c00010 crossref_primary_10_3390_pathogens9100785 crossref_primary_10_1093_nargab_lqac039 crossref_primary_10_1016_j_bmc_2020_115745 crossref_primary_10_1371_journal_ppat_1009500 crossref_primary_10_2174_1871527322666230210100048 crossref_primary_10_1371_journal_ppat_1009743 crossref_primary_10_3233_HAB_211506 crossref_primary_10_1111_2049_632X_12053 crossref_primary_10_1128_AAC_00754_20 crossref_primary_10_1128_jvi_01853_24 crossref_primary_10_1371_journal_pone_0138380 crossref_primary_10_1210_clinem_dgad165 crossref_primary_10_1007_s00894_024_06006_y crossref_primary_10_1016_j_mehy_2020_110330 crossref_primary_10_2174_0115680266276749240206101847 crossref_primary_10_1007_s10557_020_07073_y crossref_primary_10_1038_s41380_021_01309_5 crossref_primary_10_1124_molpharm_120_000119 crossref_primary_10_23736_S2724_6302_23_02515_X crossref_primary_10_1007_s11055_021_01082_6 crossref_primary_10_1016_j_repc_2022_02_014 crossref_primary_10_1073_pnas_2111199119 crossref_primary_10_1007_s00705_021_04961_y crossref_primary_10_3389_fonc_2020_01448 crossref_primary_10_1016_j_mmm_2022_08_015 crossref_primary_10_1007_s00292_021_00923_y crossref_primary_10_3390_v13091757 crossref_primary_10_1016_j_virol_2011_02_020 crossref_primary_10_3389_fendo_2021_607179 crossref_primary_10_1016_j_jmb_2021_167403 crossref_primary_10_1111_andr_12829 crossref_primary_10_1016_j_isci_2021_102322 crossref_primary_10_1007_s12070_021_02670_1 crossref_primary_10_1042_BJ20130101 crossref_primary_10_1126_sciadv_add3867 crossref_primary_10_1128_AAC_01043_16 crossref_primary_10_3389_fimmu_2022_888897 crossref_primary_10_3390_nu14224779 crossref_primary_10_1042_CS20200922 crossref_primary_10_1016_j_ijbiomac_2024_135201 crossref_primary_10_2222_jsv_61_109 crossref_primary_10_1128_jvi_01992_22 crossref_primary_10_3389_fchem_2021_784003 crossref_primary_10_1016_j_ejmech_2023_116069 crossref_primary_10_1016_j_antiviral_2012_09_013 crossref_primary_10_1128_JVI_00562_20 crossref_primary_10_3390_v15071500 crossref_primary_10_1002_1873_3468_13845 crossref_primary_10_1155_2021_8856018 crossref_primary_10_1371_journal_pone_0035876 crossref_primary_10_1016_j_virusres_2014_07_022 crossref_primary_10_1016_j_mayocp_2021_09_011 crossref_primary_10_1017_S0007114523000776 crossref_primary_10_1371_journal_ppat_1009715 crossref_primary_10_1038_s41392_023_01669_0 crossref_primary_10_3389_fpls_2022_988870 crossref_primary_10_1007_s11030_020_10176_1 crossref_primary_10_1016_j_celrep_2020_108528 crossref_primary_10_18370_2309_4117_2020_54_8_21 crossref_primary_10_1016_j_phrs_2020_104859 crossref_primary_10_3389_fonc_2021_644575 crossref_primary_10_3390_ph15050616 crossref_primary_10_3389_fendo_2022_862789 crossref_primary_10_2174_1386207325666220315114332 crossref_primary_10_1016_j_csbj_2020_07_017 crossref_primary_10_1128_mBio_00788_21 crossref_primary_10_15360_1813_9779_2022_5_18_23 crossref_primary_10_1007_s00347_020_01160_z crossref_primary_10_32604_biocell_2025_058038 crossref_primary_10_1093_jncics_pkac035 crossref_primary_10_1111_bph_16155 crossref_primary_10_1016_j_virol_2022_01_014 crossref_primary_10_2174_1389557522666220104151225 crossref_primary_10_3389_fimmu_2021_796855 crossref_primary_10_3389_fphar_2020_01258 crossref_primary_10_4155_fmc_2020_0147 crossref_primary_10_1016_j_biochi_2017_07_016 crossref_primary_10_15252_msb_202110239 crossref_primary_10_1128_JVI_03372_12 crossref_primary_10_1016_j_jbc_2022_102643 crossref_primary_10_1016_j_ijbiomac_2021_02_203 crossref_primary_10_1080_03602532_2021_1928686 crossref_primary_10_1136_bmjopen_2020_045524 crossref_primary_10_2174_0929867328666210526111318 crossref_primary_10_1016_j_bcp_2020_114057 crossref_primary_10_1146_annurev_pharmtox_061220_093932 crossref_primary_10_1038_s41564_021_00908_w crossref_primary_10_1016_j_sbi_2022_102388 crossref_primary_10_1128_JVI_00094_12 crossref_primary_10_1007_s00347_020_01281_5 crossref_primary_10_1080_22221751_2022_2026739 crossref_primary_10_1021_acs_jpcb_3c07863 crossref_primary_10_1016_j_jare_2023_10_002 crossref_primary_10_1128_JVI_01490_13 crossref_primary_10_1128_mbio_01203_24 crossref_primary_10_3390_v13010029 crossref_primary_10_1007_s13205_020_02578_7 crossref_primary_10_1016_j_lfs_2020_118056 crossref_primary_10_1016_j_virusres_2013_04_008 crossref_primary_10_3390_vaccines11040864 crossref_primary_10_1016_j_pupt_2015_07_001 crossref_primary_10_1038_s41586_022_05181_3 crossref_primary_10_3390_ph15050500 crossref_primary_10_7883_yoken_JJID_2023_353 crossref_primary_10_1371_journal_pntd_0001923 crossref_primary_10_1080_07391102_2020_1758791 crossref_primary_10_1186_s13054_020_03399_z crossref_primary_10_3390_molecules25204604 crossref_primary_10_1136_bjophthalmol_2020_317938 crossref_primary_10_1371_journal_pone_0072942 crossref_primary_10_1586_eri_12_104 crossref_primary_10_1002_rmv_2143 crossref_primary_10_1186_2045_3701_4_3 crossref_primary_10_1016_j_heliyon_2023_e15083 crossref_primary_10_1186_s13567_018_0551_9 crossref_primary_10_3390_cells11081298 crossref_primary_10_3390_pathogens9030186 crossref_primary_10_2139_ssrn_3915655 crossref_primary_10_1007_s00232_020_00136_z crossref_primary_10_1016_S0140_6736_13_61887_5 crossref_primary_10_1128_JVI_01208_19 crossref_primary_10_1128_JVI_02202_13 crossref_primary_10_1016_j_rmed_2020_105996 crossref_primary_10_1128_JVI_03677_13 crossref_primary_10_1007_s10571_020_00861_y crossref_primary_10_3389_fgene_2020_00861 crossref_primary_10_1016_j_molcel_2020_04_022 crossref_primary_10_1016_j_ympev_2023_107704 crossref_primary_10_3390_v12050491 crossref_primary_10_1371_journal_pcbi_1008461 crossref_primary_10_3390_molecules28114263 crossref_primary_10_1021_acsinfecdis_0c00701 crossref_primary_10_2147_IJN_S328090 crossref_primary_10_1128_JVI_01564_16 crossref_primary_10_1016_j_celrep_2020_108175 crossref_primary_10_1016_j_ijantimicag_2020_106004 crossref_primary_10_1016_j_stem_2021_04_028 crossref_primary_10_1007_s41666_021_00106_7 crossref_primary_10_1038_s41588_022_01110_2 crossref_primary_10_3389_fmed_2021_637642 crossref_primary_10_1002_rmv_2130 crossref_primary_10_2217_fvl_2020_0129 crossref_primary_10_1007_s11886_020_01292_3 crossref_primary_10_1515_hsz_2022_0323 crossref_primary_10_3390_v4040557 crossref_primary_10_3390_ijms21155559 crossref_primary_10_1016_j_bbrc_2020_11_026 crossref_primary_10_1016_j_jbc_2023_104763 crossref_primary_10_1016_j_jbc_2021_100847 crossref_primary_10_1038_s41467_022_29255_y crossref_primary_10_1128_AAC_00065_15 crossref_primary_10_26508_lsa_202403182 crossref_primary_10_1038_s41467_022_35590_x crossref_primary_10_1038_s41588_020_00759_x crossref_primary_10_1073_pnas_2206610119 crossref_primary_10_1111_exd_14186 crossref_primary_10_3390_ijms21134639 crossref_primary_10_1038_s41598_022_25399_5 crossref_primary_10_3389_fmicb_2021_682603 crossref_primary_10_1039_D0SC05064D crossref_primary_10_1017_S0033583523000021 crossref_primary_10_1016_j_ijid_2020_10_033 crossref_primary_10_34133_2020_2402961 crossref_primary_10_15252_msb_20209610 crossref_primary_10_1080_07391102_2020_1792346 crossref_primary_10_1186_s43042_020_00099_9 crossref_primary_10_3201_eid2707_204660 crossref_primary_10_3390_cells12182307 crossref_primary_10_1021_acsmedchemlett_3c00035 crossref_primary_10_3389_fmicb_2022_943877 crossref_primary_10_3390_molecules25215007 crossref_primary_10_3390_vaccines10070985 crossref_primary_10_1371_journal_pone_0035108 crossref_primary_10_3390_cells11081262 crossref_primary_10_3390_microorganisms8101492 crossref_primary_10_1007_s11886_020_01293_2 crossref_primary_10_3390_v16081243 crossref_primary_10_2174_1566524023666230613141746 crossref_primary_10_1186_s13287_020_01804_6 crossref_primary_10_1021_acs_analchem_4c05966 crossref_primary_10_1021_acsinfecdis_1c00023 crossref_primary_10_1128_jvi_01587_24 crossref_primary_10_3389_fgene_2020_00872 crossref_primary_10_1080_14779072_2020_1814143 crossref_primary_10_1016_j_jbc_2021_100701 crossref_primary_10_1016_j_freeradbiomed_2011_04_027 crossref_primary_10_1038_s41467_021_21171_x crossref_primary_10_3389_fcvm_2022_1013262 crossref_primary_10_3390_v13010109 crossref_primary_10_1007_s00011_020_01370_w crossref_primary_10_3389_fphar_2021_619524 crossref_primary_10_3390_v13030384 crossref_primary_10_1016_j_vph_2021_106829 crossref_primary_10_1038_s41392_021_00653_w crossref_primary_10_3389_fcimb_2020_575404 crossref_primary_10_1039_D3CP01723K crossref_primary_10_16899_jcm_839810 crossref_primary_10_1073_pnas_2007837117 crossref_primary_10_1124_jpet_120_000123 crossref_primary_10_3390_v12050571 crossref_primary_10_1038_s41598_023_39071_z crossref_primary_10_2174_1570178619666220622091801 crossref_primary_10_1371_journal_pone_0149651 crossref_primary_10_1002_med_21763 crossref_primary_10_3389_fchem_2023_1128859 crossref_primary_10_1038_s41392_022_01087_8 crossref_primary_10_3390_v12040404 crossref_primary_10_1093_cid_ciaa1517 crossref_primary_10_3390_ijms241310874 crossref_primary_10_3390_v14040827 crossref_primary_10_1371_journal_pone_0260187 crossref_primary_10_3389_fmicb_2020_01723 crossref_primary_10_3390_v13112157 crossref_primary_10_1039_D0RA05434H crossref_primary_10_1371_journal_pone_0179177 crossref_primary_10_2174_1872208315666210402112805 crossref_primary_10_1007_s40618_020_01383_6 crossref_primary_10_1038_s41467_020_19045_9 crossref_primary_10_3390_ijms21134675 crossref_primary_10_4062_biomolther_2021_048 crossref_primary_10_1038_s41591_020_0868_6 crossref_primary_10_1093_gerona_glaa149 crossref_primary_10_1016_j_isci_2020_101585 crossref_primary_10_1007_s40588_021_00157_9 crossref_primary_10_1128_JVI_00398_21 crossref_primary_10_1038_s41467_020_15562_9 crossref_primary_10_1128_JVI_01815_18 crossref_primary_10_1080_17460441_2023_2175812 crossref_primary_10_3390_v15041001 crossref_primary_10_1038_s41589_022_01059_7 crossref_primary_10_1093_cvr_cvaa097 crossref_primary_10_1016_j_coviro_2011_05_014 crossref_primary_10_1002_hep_27426 crossref_primary_10_3390_pathogens13020113 crossref_primary_10_1590_0001_3765202120200510 crossref_primary_10_1016_j_jaim_2021_05_003 crossref_primary_10_3389_fcimb_2024_1415885 crossref_primary_10_3390_ijerph192214955 crossref_primary_10_3390_nu14051000 crossref_primary_10_3390_cells13050432 crossref_primary_10_3390_v14122728 crossref_primary_10_3390_vision6030046 crossref_primary_10_1016_j_androl_2020_05_001 crossref_primary_10_3390_v9050114 crossref_primary_10_3390_vaccines8020335 crossref_primary_10_1128_msphere_00558_22 crossref_primary_10_1038_s41586_021_03491_6 crossref_primary_10_3390_antiox9080659 crossref_primary_10_1080_14756366_2021_1886093 crossref_primary_10_1007_s40203_021_00114_w crossref_primary_10_1016_j_clim_2020_108591 crossref_primary_10_3390_ijerph182212011 crossref_primary_10_1074_jbc_REV120_013930 crossref_primary_10_3389_frai_2022_910216 crossref_primary_10_3390_ijms22115817 crossref_primary_10_1016_j_jbc_2021_100902 crossref_primary_10_1080_07391102_2020_1798813 crossref_primary_10_1016_j_medntd_2020_100043 crossref_primary_10_3390_molecules25102271 crossref_primary_10_14336_AD_2020_1211 crossref_primary_10_1002_jmv_25985 crossref_primary_10_1016_j_amjms_2021_12_006 crossref_primary_10_1038_s41580_021_00418_x crossref_primary_10_2174_1381612826666201023143956 crossref_primary_10_1080_13813455_2020_1797105 crossref_primary_10_1016_j_imu_2020_100451 crossref_primary_10_1002_jev2_70061 crossref_primary_10_1016_j_celrep_2020_107915 crossref_primary_10_1371_journal_ppat_1003774 crossref_primary_10_1096_fj_202002512 crossref_primary_10_7759_cureus_43344 crossref_primary_10_3390_life14020163 crossref_primary_10_1042_BST20230324 crossref_primary_10_3390_ijms22031308 crossref_primary_10_1007_s00203_021_02727_3 crossref_primary_10_1080_19420862_2022_2057832 crossref_primary_10_14348_molcells_2021_0076 crossref_primary_10_1002_cbin_11623 crossref_primary_10_1097_FJC_0000000000000960 crossref_primary_10_3390_cancers13061250 crossref_primary_10_3390_v14092017 crossref_primary_10_1590_1678_4685_gmb_2020_0452 crossref_primary_10_1016_j_antiviral_2020_104792 crossref_primary_10_1080_14756366_2016_1193732 crossref_primary_10_1111_andr_13037 crossref_primary_10_1016_j_annonc_2020_04_479 crossref_primary_10_1007_s40265_017_0830_1 crossref_primary_10_1016_j_job_2025_100619 crossref_primary_10_1080_07391102_2021_1892529 crossref_primary_10_1136_jclinpath_2020_206867 crossref_primary_10_3390_biology11010022 crossref_primary_10_2478_jim_2020_0022 crossref_primary_10_1080_14728222_2021_1952985 crossref_primary_10_1016_j_slasd_2024_100178 crossref_primary_10_1038_s41598_022_11902_5 crossref_primary_10_1016_j_ijid_2020_12_041 crossref_primary_10_1080_0886022X_2020_1797791 crossref_primary_10_2174_0929867329666220627121416 crossref_primary_10_1016_j_virol_2011_11_031 crossref_primary_10_1016_j_virol_2021_11_012 crossref_primary_10_1017_S1049023X20000837 crossref_primary_10_14218_JERP_2021_00050 crossref_primary_10_7759_cureus_68303 crossref_primary_10_1128_jvi_00916_23 crossref_primary_10_1016_j_placenta_2020_05_012 crossref_primary_10_1128_JVI_05300_11 crossref_primary_10_1111_aji_13339 crossref_primary_10_3390_ijerph17103433 crossref_primary_10_1038_s42003_022_03766_2 crossref_primary_10_3389_fmed_2021_644678 crossref_primary_10_1186_s43556_020_00017_w crossref_primary_10_4103_aja202246 crossref_primary_10_1016_j_isci_2024_110387 crossref_primary_10_1016_j_vacune_2023_07_005 crossref_primary_10_1016_j_coviro_2017_03_018 crossref_primary_10_3390_microorganisms9010093 crossref_primary_10_3390_cells11010045 crossref_primary_10_1155_2020_2421689 crossref_primary_10_1186_s12985_023_01968_6 crossref_primary_10_1038_s41467_021_21972_0 crossref_primary_10_1128_mSphere_00159_21 crossref_primary_10_1161_HYPERTENSIONAHA_120_15082 crossref_primary_10_1002_advs_202100985 crossref_primary_10_1021_acs_jproteome_0c00422 crossref_primary_10_1186_s40246_021_00304_9 crossref_primary_10_2174_0929867328666210420103021 crossref_primary_10_3390_v12121465 crossref_primary_10_1016_j_imbio_2020_152027 crossref_primary_10_1016_j_virol_2014_01_002 crossref_primary_10_1371_journal_pbio_3001738 crossref_primary_10_2174_1568026620999200517043137 crossref_primary_10_1016_j_antiviral_2020_104742 crossref_primary_10_1016_j_meegid_2020_104669 crossref_primary_10_1126_sciadv_aav4580 crossref_primary_10_1016_j_imu_2020_100407 crossref_primary_10_5937_asn2081995B crossref_primary_10_3390_biomedicines9050525 crossref_primary_10_1128_mBio_02492_20 crossref_primary_10_1158_2159_8290_CD_20_0451 crossref_primary_10_1016_j_bioorg_2022_105985 crossref_primary_10_1016_j_virol_2024_110218 crossref_primary_10_1128_CMR_00102_14 crossref_primary_10_1016_j_virol_2017_07_033 crossref_primary_10_1002_jcp_29868 crossref_primary_10_3390_life12091408 crossref_primary_10_3390_cells9112528 crossref_primary_10_3390_ijms23158485 crossref_primary_10_4252_wjsc_v13_i9_1318 crossref_primary_10_3390_cancers12082186 crossref_primary_10_1097_HJH_0000000000002469 crossref_primary_10_1155_2021_2706789 crossref_primary_10_3390_ijms22063060 crossref_primary_10_1016_j_meegid_2020_104670 crossref_primary_10_1093_cvr_cvaa106 crossref_primary_10_1128_JVI_02415_20 crossref_primary_10_1186_s12985_023_02062_7 crossref_primary_10_1038_s41467_021_24342_y crossref_primary_10_3390_v13030435 crossref_primary_10_1016_j_cell_2021_02_029 crossref_primary_10_1016_j_isci_2022_104295 crossref_primary_10_1007_s00345_020_03284_y crossref_primary_10_1016_j_job_2022_04_004 crossref_primary_10_1128_JVI_01301_20 crossref_primary_10_1016_j_gendis_2022_11_016 crossref_primary_10_1128_JVI_00297_14 crossref_primary_10_3390_molecules26020448 crossref_primary_10_3389_fimmu_2020_552925 crossref_primary_10_1016_j_molstruc_2021_130534 crossref_primary_10_1016_j_virol_2020_01_004 crossref_primary_10_1128_JVI_01427_14 crossref_primary_10_1016_j_jaut_2020_102434 crossref_primary_10_1016_j_cell_2020_02_052 crossref_primary_10_1016_j_ijsu_2020_07_032 crossref_primary_10_1016_j_cell_2020_02_058 crossref_primary_10_1016_j_etap_2021_103657 crossref_primary_10_1080_22221751_2022_2114850 crossref_primary_10_3390_ijms23031351 crossref_primary_10_3897_rrpharmacology_6_53633 crossref_primary_10_1038_s41598_021_95308_9 crossref_primary_10_3343_alm_2021_41_2_129 crossref_primary_10_5888_pcd17_200247 crossref_primary_10_1038_s42003_022_03613_4 crossref_primary_10_3390_v14122682 crossref_primary_10_1016_j_bioorg_2020_104269 crossref_primary_10_1016_j_virusres_2024_199485 crossref_primary_10_1038_s41392_020_0195_x crossref_primary_10_1016_j_antiviral_2013_11_004 |
| Cites_doi | 10.1073/pnas.0503203102 10.1371/journal.pone.0007870 10.1038/nm1267 10.1074/jbc.M105044200 10.1128/JVI.00676-08 10.1128/JVI.00959-09 10.1128/JVI.01118-06 10.1128/JVI.01248-09 10.1128/JVI.78.11.5642-5650.2004 10.1056/NEJMoa030747 10.1016/j.bbrc.2004.07.060 10.2353/ajpath.2008.071060 10.1128/JVI.01697-07 10.1073/pnas.0306446101 10.1126/science.1110656 10.1002/path.1440 10.1073/pnas.0809524106 10.1002/path.1597 10.1080/10409230802058320 10.1016/j.molmed.2009.05.003 10.1038/nature02145 10.1128/JVI.02205-08 10.1074/jbc.M508381200 10.1128/JVI.80.8.4174-4178.2006 10.1111/j.1365-2613.2007.00567.x 10.1128/JVI.00442-06 10.1016/j.jsb.2006.03.019 10.1128/JVI.00253-07 10.1128/JVI.01412-08 10.1128/JVI.00415-08 10.7883/yoken.JJID.2008.157 10.1073/pnas.0505577102 10.1006/geno.1997.4845 10.7883/yoken.JJID.2005.88 |
| ContentType | Journal Article |
| Copyright | 2015 INIST-CNRS Copyright © 2010, American Society for Microbiology 2010 |
| Copyright_xml | – notice: 2015 INIST-CNRS – notice: Copyright © 2010, American Society for Microbiology 2010 |
| DBID | AAYXX CITATION IQODW CGR CUY CVF ECM EIF NPM 7X8 7U9 H94 5PM |
| DOI | 10.1128/JVI.01542-10 |
| DatabaseName | CrossRef Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic Virology and AIDS Abstracts AIDS and Cancer Research Abstracts PubMed Central (Full Participant titles) |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic AIDS and Cancer Research Abstracts Virology and AIDS Abstracts |
| DatabaseTitleList | AIDS and Cancer Research Abstracts MEDLINE AIDS and Cancer Research Abstracts CrossRef MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Biology |
| EISSN | 1098-5514 |
| EndPage | 12664 |
| ExternalDocumentID | PMC3004351 20926566 23530073 10_1128_JVI_01542_10 jvi_84_24_12658 |
| Genre | Research Support, Non-U.S. Gov't Journal Article |
| GroupedDBID | --- -~X 0R~ 18M 29L 2WC 39C 3O- 4.4 53G 5GY 5RE 5VS 85S AAFWJ AAGFI AAYXX ABPPZ ACGFO ACNCT ADBBV AENEX AGVNZ ALMA_UNASSIGNED_HOLDINGS AOIJS BAWUL BTFSW C1A CITATION CS3 DIK E3Z EBS EJD F5P FRP GX1 H13 HYE HZ~ IH2 KQ8 N9A O9- OK1 P2P RHI RNS RPM RSF TR2 UPT W2D W8F WH7 WOQ YQT ~02 ~KM .55 .GJ 41~ 6TJ AAYJJ ADXHL AFFNX AI. D0S IQODW MVM OHT VH1 X7M Y6R ZGI ZXP CGR CUY CVF ECM EIF NPM PKN RHF UCJ 7X8 7U9 H94 5PM |
| ID | FETCH-LOGICAL-c666t-280224e32e5f30f783da1b8741be91b4cf722e7d0c2284b8c81c607bd2ca4cff3 |
| ISSN | 0022-538X 1098-5514 |
| IngestDate | Thu Aug 21 13:44:58 EDT 2025 Fri Jul 11 15:51:41 EDT 2025 Fri Jul 11 06:00:32 EDT 2025 Fri Jul 11 06:22:58 EDT 2025 Wed Feb 19 02:30:56 EST 2025 Mon Jul 21 09:16:32 EDT 2025 Thu Apr 24 23:01:30 EDT 2025 Tue Jul 01 00:57:47 EDT 2025 Wed May 18 15:26:02 EDT 2016 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 24 |
| Keywords | Infection Virus Transmembrane protein Lung disease Coronavirus Respiratory disease Viral disease Severe acute respiratory syndrome Coronaviridae Nidovirales |
| Language | English |
| License | CC BY 4.0 |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c666t-280224e32e5f30f783da1b8741be91b4cf722e7d0c2284b8c81c607bd2ca4cff3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Article-2 ObjectType-Feature-1 |
| OpenAccessLink | https://www.ncbi.nlm.nih.gov/pmc/articles/3004351 |
| PMID | 20926566 |
| PQID | 812132780 |
| PQPubID | 23462 |
| PageCount | 7 |
| ParticipantIDs | proquest_miscellaneous_860376278 proquest_miscellaneous_812132780 crossref_primary_10_1128_JVI_01542_10 pubmedcentral_primary_oai_pubmedcentral_nih_gov_3004351 pubmed_primary_20926566 pascalfrancis_primary_23530073 highwire_asm_jvi_84_24_12658 proquest_miscellaneous_860374918 crossref_citationtrail_10_1128_JVI_01542_10 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2010-12-01 |
| PublicationDateYYYYMMDD | 2010-12-01 |
| PublicationDate_xml | – month: 12 year: 2010 text: 2010-12-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | Washington, DC |
| PublicationPlace_xml | – name: Washington, DC – name: United States |
| PublicationTitle | Journal of Virology |
| PublicationTitleAlternate | J Virol |
| PublicationYear | 2010 |
| Publisher | American Society for Microbiology American Society for Microbiology (ASM) |
| Publisher_xml | – name: American Society for Microbiology – name: American Society for Microbiology (ASM) |
| References | e_1_3_2_27_2 e_1_3_2_28_2 e_1_3_2_29_2 e_1_3_2_21_2 e_1_3_2_22_2 e_1_3_2_23_2 e_1_3_2_24_2 e_1_3_2_25_2 (e_1_3_2_2_2) 2008; 52 (e_1_3_2_20_2) 2008; 61 e_1_3_2_9_2 e_1_3_2_15_2 e_1_3_2_38_2 e_1_3_2_8_2 e_1_3_2_16_2 e_1_3_2_37_2 e_1_3_2_7_2 e_1_3_2_6_2 e_1_3_2_18_2 e_1_3_2_19_2 e_1_3_2_30_2 e_1_3_2_32_2 e_1_3_2_10_2 e_1_3_2_31_2 e_1_3_2_5_2 e_1_3_2_11_2 (e_1_3_2_26_2) 2005; 58 e_1_3_2_34_2 e_1_3_2_4_2 e_1_3_2_12_2 e_1_3_2_33_2 e_1_3_2_3_2 e_1_3_2_36_2 e_1_3_2_14_2 e_1_3_2_35_2 (e_1_3_2_17_2) 2008; 3 (e_1_3_2_13_2) 2004; 203 |
| References_xml | – volume: 203 start-page: 631 year: 2004 ident: e_1_3_2_13_2 publication-title: A first step in understanding SARS pathogenesis. J. Pathol. – ident: e_1_3_2_22_2 doi: 10.1073/pnas.0503203102 – ident: e_1_3_2_16_2 doi: 10.1371/journal.pone.0007870 – ident: e_1_3_2_18_2 doi: 10.1038/nm1267 – ident: e_1_3_2_10_2 doi: 10.1074/jbc.M105044200 – ident: e_1_3_2_30_2 doi: 10.1128/JVI.00676-08 – volume: 3 start-page: 167 year: 2008 ident: e_1_3_2_17_2 publication-title: J. Mol. Gen. Med. – ident: e_1_3_2_21_2 doi: 10.1128/JVI.00959-09 – ident: e_1_3_2_5_2 doi: 10.1128/JVI.01118-06 – ident: e_1_3_2_12_2 doi: 10.1128/JVI.01248-09 – ident: e_1_3_2_38_2 doi: 10.1128/JVI.78.11.5642-5650.2004 – ident: e_1_3_2_11_2 doi: 10.1056/NEJMoa030747 – ident: e_1_3_2_25_2 doi: 10.1016/j.bbrc.2004.07.060 – ident: e_1_3_2_23_2 doi: 10.2353/ajpath.2008.071060 – ident: e_1_3_2_35_2 doi: 10.1128/JVI.01697-07 – ident: e_1_3_2_32_2 doi: 10.1073/pnas.0306446101 – ident: e_1_3_2_7_2 doi: 10.1126/science.1110656 – ident: e_1_3_2_9_2 doi: 10.1002/path.1440 – ident: e_1_3_2_3_2 doi: 10.1073/pnas.0809524106 – ident: e_1_3_2_33_2 doi: 10.1002/path.1597 – ident: e_1_3_2_37_2 doi: 10.1080/10409230802058320 – ident: e_1_3_2_8_2 doi: 10.1016/j.molmed.2009.05.003 – ident: e_1_3_2_19_2 doi: 10.1038/nature02145 – ident: e_1_3_2_6_2 doi: 10.1128/JVI.02205-08 – ident: e_1_3_2_14_2 doi: 10.1074/jbc.M508381200 – ident: e_1_3_2_29_2 doi: 10.1128/JVI.80.8.4174-4178.2006 – ident: e_1_3_2_24_2 doi: 10.1111/j.1365-2613.2007.00567.x – ident: e_1_3_2_28_2 doi: 10.1128/JVI.00442-06 – ident: e_1_3_2_34_2 doi: 10.1016/j.jsb.2006.03.019 – volume: 52 start-page: 118 year: 2008 ident: e_1_3_2_2_2 publication-title: Microbiol. Immunol. – ident: e_1_3_2_15_2 doi: 10.1128/JVI.00253-07 – ident: e_1_3_2_36_2 doi: 10.1128/JVI.01412-08 – ident: e_1_3_2_4_2 doi: 10.1128/JVI.00415-08 – volume: 61 start-page: 157 year: 2008 ident: e_1_3_2_20_2 publication-title: Jpn. J. Infect. Dis. doi: 10.7883/yoken.JJID.2008.157 – ident: e_1_3_2_31_2 doi: 10.1073/pnas.0505577102 – ident: e_1_3_2_27_2 doi: 10.1006/geno.1997.4845 – volume: 58 start-page: 88 year: 2005 ident: e_1_3_2_26_2 publication-title: Jpn. J. Infect. Dis. doi: 10.7883/yoken.JJID.2005.88 |
| SSID | ssj0014464 |
| Score | 2.5453784 |
| Snippet | Article Usage Stats
Services
JVI
Citing Articles
Google Scholar
PubMed
Related Content
Social Bookmarking
CiteULike
Delicious
Digg
Facebook
Google+
Mendeley... The distribution of the severe acute respiratory syndrome coronavirus (SARS-CoV) receptor, an angiotensin-converting enzyme 2 (ACE2), does not strictly... |
| SourceID | pubmedcentral proquest pubmed pascalfrancis crossref highwire |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 12658 |
| SubjectTerms | Animals Biological and medical sciences Blotting, Western Chlorocebus aethiops Fluorescent Antibody Technique Fundamental and applied biological sciences. Psychology Giant Cells - metabolism Giant Cells - pathology Giant Cells - virology Humans Influenza A virus Lung - cytology Lung - metabolism Lung - virology Macaca fascicularis Male Membrane Glycoproteins - metabolism Microbiology Miscellaneous Peptidyl-Dipeptidase A - metabolism SARS coronavirus SARS Virus - pathogenicity Serine Endopeptidases - metabolism Severe Acute Respiratory Syndrome - metabolism Severe Acute Respiratory Syndrome - pathology Severe Acute Respiratory Syndrome - virology Spike Glycoprotein, Coronavirus Vero Cells Viral Envelope Proteins - metabolism Virion - physiology Virology Virus Internalization Virus Replication Virus-Cell Interactions |
| Title | Efficient Activation of the Severe Acute Respiratory Syndrome Coronavirus Spike Protein by the Transmembrane Protease TMPRSS2 |
| URI | http://jvi.asm.org/content/84/24/12658.abstract https://www.ncbi.nlm.nih.gov/pubmed/20926566 https://www.proquest.com/docview/812132780 https://www.proquest.com/docview/860374918 https://www.proquest.com/docview/860376278 https://pubmed.ncbi.nlm.nih.gov/PMC3004351 |
| Volume | 84 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1bT9swFLYqpkl7mXZfN4b8sD2hsNZJE_cRISaGFIRImXiLYtcZoWuL2oapSPun-zE7x5fUHbALL1FrO87lfPE5ts_5DiHvlYwiVcQsCHnZgwnKMAy4EnFQxJHkvaGSid6KSY_ig9Po8Kx31mr99LyW6oXYkde3xpXcR6pQBnLFKNn_kGzTKRTAb5AvHEHCcPwnGe9r_gfczd-VLk2Z2_TPFDyOggp0BDjxNtQzy1EAQ8EMzPCralbPt7PLaqQwagCTX2qTFHP-oB4bqzFMqCe2EnTe9iA9PskydodZi3Fz_kp9Wizm9bIYayM1O68X01HdrEAXXwtjvR5NZ9Vy2iz3nOubNd4e13B2oxaK74XJBJlWy3pU-WsWN_0_3GaU75maVh7zFFjXu1nqFkNWcQcwPJ8ZzWWGa2RDRZvPH89NyjmLWxZ5o3OXxYYn3qp6-G8o1G_qEYaxEYdfPu-gjckC43rrQepyrDHFOn2GFvFKmzY-jsfpHrKZhRjf_4DBJCZ0a0l2jwsm4pHjssfncmEZjH_0L4x01fYq67aT47NGd95iDl90aVKx3DZX-t3l17OhBk_IY4sSumuQ_JS01OQZeWjSoS6fkx8NnukKz3RaUgAjNXimGs_UwzN1eKYenqnGM7V4pmKpu1jDM3V4phbPL8jpp_3B3kFg04MEEubci4BhlHikQqZ6ZdgpEx4Oi67gYCIL1e-KSJYJYyoZdiQDG0xwybsy7iRiyGQBlWX4kmxMphP1mlApeQeJFKXod7FKCAZFPTGMkrKE3ttk2734XFrufEzh8i3Xc2jGc5BYriUGJW3yoWl9aThj7mi36WSYF_NxfnFV5TzKWZRroLbJ1ppcm75Y2Atxh71NqBN0DkoBd_rg9U3rec6RqJElvPOHJjEyT_W7_C9NYuimTV4Z9KxuwSKyTZI1XDUNkLV-vWZSnWv2evtRvLn3mW_Jo9WYskk2FrNavYOZwUJs6Q_sF0slFPE |
| linkProvider | National Library of Medicine |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Efficient+Activation+of+the+Severe+Acute+Respiratory+Syndrome+Coronavirus+Spike+Protein+by+the+Transmembrane+Protease+TMPRSS2&rft.jtitle=Journal+of+virology&rft.au=Matsuyama%2C+Shutoku&rft.au=Nagata%2C+Noriyo&rft.au=Shirato%2C+Kazuya&rft.au=Kawase%2C+Miyuki&rft.date=2010-12-01&rft.pub=American+Society+for+Microbiology+%28ASM%29&rft.issn=0022-538X&rft.eissn=1098-5514&rft.volume=84&rft.issue=24&rft.spage=12658&rft.epage=12664&rft_id=info:doi/10.1128%2FJVI.01542-10&rft_id=info%3Apmid%2F20926566&rft.externalDocID=PMC3004351 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0022-538X&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0022-538X&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0022-538X&client=summon |