The immune factors driving DNA methylation variation in human blood

• Published in: Nature communications Vol. 13; no. 1; pp. 5895 - 20
• Main Authors: Bergstedt, Jacob, Azzou, Sadoune Ait Kaci, Tsuo, Kristin, Jaquaniello, Anthony, Urrutia, Alejandra, Rotival, Maxime, Lin, David T. S., MacIsaac, Julia L., Kobor, Michael S., Albert, Matthew L., Duffy, Darragh, Patin, Etienne, Quintana-Murci, Lluís
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 06.10.2022; Nature Publishing Group; Nature Portfolio
• Subjects: 45; 45/22; 45/43; 49; 49/61; 631/208/176/1988; 631/208/177; 631/250/2502/2170; Adult; Adults; Aging; Aging - genetics; Blood; Composition; Cytomegalovirus; Deoxyribonucleic acid; DNA; DNA Methylation; Epigenesis, Genetic; Epigenetics; Epigenomics - methods; Gene sequencing; Humanities and Social Sciences; Humans; Immunologic Factors; Immunological memory; Immunology; Leukocytes; Life Sciences; Lymphocytes; Lymphocytes T; Medicin och hälsovetenskap; Memory cells; multidisciplinary; Nucleotide sequence; Science; Science (multidisciplinary); Variation

Epigenetic changes are required for normal development, yet the nature and respective contribution of factors that drive epigenetic variation in humans remain to be fully characterized. Here, we assessed how the blood DNA methylome of 884 adults is affected by DNA sequence variation, age, sex and 13...