Interspecies Comparison of Human and Murine Scleroderma Reveals IL-13 and CCL2 as Disease Subset-Specific Targets

• Published in: The American journal of pathology Vol. 180; no. 3; pp. 1080 - 1094
• Main Authors: Greenblatt, Matthew B., Sargent, Jennifer L., Farina, Giuseppina, Tsang, Kelly, Lafyatis, Robert, Glimcher, Laurie H., Whitfield, Michael L., Aliprantis, Antonios O.
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Elsevier Inc 01.03.2012; American Society for Investigative Pathology
• Subjects: Animals; Biological and medical sciences; Chemokine CCL2 - antagonists & inhibitors; Chemokine CCL2 - genetics; Disease Models, Animal; Fibroblasts - metabolism; Gene Expression; Gene Expression Profiling; Graft vs Host Disease - genetics; Humans; Interleukin-13 - genetics; Investigative techniques, diagnostic techniques (general aspects); Macrophages - metabolism; Medical sciences; Mice; Mice, Inbred BALB C; Pathology; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques; Receptors, Interleukin-13 - metabolism; Receptors, Interleukin-4 - metabolism; Regular; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis; Scleroderma, Systemic - genetics; Signal Transduction; T-Lymphocytes - metabolism; Up-Regulation; Human; Immunopathology; Connective tissue disease; Skin disease; Targeting; Cytokine; Rodentia; Autoimmune disease; Interleukin 13; Vertebrata; Anatomic pathology; Mammalia; Mouse; Animal; Systemic disease; Scleroderma; Comparative study; Monocyte chemoattractant protein 1

Development of personalized treatment regimens is hampered by lack of insight into how individual animal models reflect subsets of human disease, and autoimmune and inflammatory conditions have proven resistant to such efforts. Scleroderma is a lethal autoimmune disease characterized by fibrosis, wi...