Interspecies Comparison of Human and Murine Scleroderma Reveals IL-13 and CCL2 as Disease Subset-Specific Targets - Greenblatt, Matthew B.; Sargent, Jennifer L.; Farina, Giuseppina; Tsang, Kelly; Lafyatis, Robert; Glimcher, Laurie H.; Whitfield, Michael L.; Aliprantis, Antonios O. (The American journal of pathology, 2012)
Keywords: Animals; Biological and medical sciences; Chemokine CCL2 - antagonists & inhibitors; Chemokine CCL2 - genetics; Disease Models, Animal; Fibroblasts - metabolism; Gene Expression; Gene Expression Profiling; Graft vs Host Disease - genetics; Humans; Interleukin-13 - genetics; Investigative techniques, diagnostic techniques (general aspects); Macrophages - metabolism; Medical sciences; Mice; Mice, Inbred BALB C; Pathology; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques; Receptors, Interleukin-13 - metabolism; Receptors, Interleukin-4 - metabolism; Regular; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis; Scleroderma, Systemic - genetics; Signal Transduction; T-Lymphocytes - metabolism; Up-Regulation; Human; Immunopathology; Connective tissue disease; Skin disease; Targeting; Cytokine; Rodentia; Autoimmune disease; Interleukin 13; Vertebrata; Anatomic pathology; Mammalia; Mouse; Animal; Systemic disease; Scleroderma; Comparative study; Monocyte chemoattractant protein 1