Transcriptional profiling and therapeutic targeting of oxidative stress in neuroinflammation

• Published in: Nature immunology Vol. 21; no. 5; pp. 513 - 524
• Main Authors: Mendiola, Andrew S., Ryu, Jae Kyu, Bardehle, Sophia, Meyer-Franke, Anke, Ang, Kenny Kean-Hooi, Wilson, Chris, Baeten, Kim M., Hanspers, Kristina, Merlini, Mario, Thomas, Sean, Petersen, Mark A., Williams, Alexander, Thomas, Reuben, Rafalski, Victoria A., Meza-Acevedo, Rosa, Tognatta, Reshmi, Yan, Zhaoqi, Pfaff, Samuel J., Machado, Michael R., Bedard, Catherine, Rios Coronado, Pamela E., Jiang, Xiqian, Wang, Jin, Pleiss, Michael A., Green, Ari J., Zamvil, Scott S., Pico, Alexander R., Bruneau, Benoit G., Arkin, Michelle R., Akassoglou, Katerina
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.05.2020; Nature Publishing Group
• Subjects: 631/250/2504/342/1952; 631/250/371; Animals; Antioxidants - therapeutic use; Biomedical and Life Sciences; Biomedicine; Care and treatment; Central nervous system; Central nervous system diseases; Coagulation; Degeneration; Development and progression; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental - drug therapy; Encephalomyelitis, Autoimmune, Experimental - genetics; Female; Gene Expression Profiling - methods; Gene Regulatory Networks; Genes; Genetic aspects; Genetic transcription; Glutathione; Health aspects; High-Throughput Screening Assays; Humans; Immunity, Innate; Immunology; Infectious Diseases; Inflammation; Isoxazoles - therapeutic use; Macrophages; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Microglia; Microglia - physiology; Multiple sclerosis; Multiple Sclerosis - drug therapy; Multiple Sclerosis - genetics; Nervous system; Neurodegeneration; Neurogenic Inflammation - drug therapy; Neurogenic Inflammation - genetics; Neuroprotection; Neurotoxicity; Oxidation; Oxidative Stress; Ribonucleic acid; RNA; Sequence Analysis, RNA; Single-Cell Analysis; Therapeutic targets; Transcription; Transcriptomics; United States

Oxidative stress is a central part of innate immune-induced neurodegeneration. However, the transcriptomic landscape of central nervous system (CNS) innate immune cells contributing to oxidative stress is unknown, and therapies to target their neurotoxic functions are not widely available. Here, we...