Adipose tissue gene expression is differentially regulated with different rates of weight loss in overweight and obese humans

• Published in: International Journal of Obesity Vol. 41; no. 2; pp. 309 - 316
• Main Authors: Vink, R G, Roumans, N J, Fazelzadeh, P, Tareen, S H K, Boekschoten, M V, van Baak, M A, Mariman, E C
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.02.2017; Nature Publishing Group
• Subjects: 38/61; 631/250; 631/443/319/333; Adipocytes - metabolism; Adipogenesis; Adipose tissue; Adipose tissues; Analysis; Angiogenesis; Biology; Biopsy; Biosynthesis; Body fat; Body mass index; Body size; Body weight; Body weight loss; Caloric Restriction; Calories; Chair Nutrition Metabolism and Genomics; Development and progression; Diet; Diet, Reducing; DNA microarrays; Energy; Epidemiology; Extracellular Matrix - metabolism; Female; Gene expression; Gene Expression Regulation; Genes; Genetic aspects; Genomics; Health aspects; Health Promotion and Disease Prevention; Health risks; HNE Nutrition, Metabolism and Genomics; HNE Voeding, Metabolisme en Genomics; Humans; Hypocaloric diet; Internal Medicine; Male; Medical research; Medicine; Medicine & Public Health; Medicine, Experimental; Metabolic Diseases; Metabolism; Middle Aged; Mitochondria; Nutrient deficiency; Nutrition research; Nutrition, Metabolism and Genomics; Obesity; Obesity - genetics; Obesity - physiopathology; original-article; Overweight; Overweight - genetics; Overweight - physiopathology; Public Health; Risk factors; Subcutaneous Fat, Abdominal - metabolism; Tissue Array Analysis; Transcriptomes; VLAG; Voeding, Metabolisme en Genomica; Weight control; Weight loss; Weight Loss - genetics; Weight Loss - physiology; Netherlands

Background/Objectives: Moderate weight loss (WL) can ameliorate adverse health effects associated with obesity, reflected by an improved adipose tissue (AT) gene expression profile. However, the effect of rate of WL on the AT transcriptome is unknown. We investigated the global AT gene expression pr...