Reinforcement versus fluidization in cytoskeletal mechanoresponsiveness

• Published in: PloS one Vol. 4; no. 5; p. e5486
• Main Authors: Krishnan, Ramaswamy, Park, Chan Young, Lin, Yu-Chun, Mead, Jere, Jaspers, Richard T, Trepat, Xavier, Lenormand, Guillaume, Tambe, Dhananjay, Smolensky, Alexander V, Knoll, Andrew H, Butler, James P, Fredberg, Jeffrey J
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 08.05.2009; Public Library of Science (PLoS)
• Subjects: Adaptation; Adaptations; Biomechanical Phenomena; Biophysics; Biophysics/Experimental Biophysical Methods; Bladder; Blood vessels; Cell Biology; Cell Biology/Cytoskeleton; Cells, Cultured; Cellular control mechanisms; Citosquelet; Colorectal cancer; Cytoskeletal proteins; Cytoskeleton; Cytoskeleton - physiology; Fluidization; Fluidizing; Fragility; Homeostasis; Humans; Lungs; Mechanics; Mechanotransduction, Cellular; Metabolism; Metastasis; Muscle contraction; Myocytes, Smooth Muscle - cytology; Nanotechnology; Physiology; Physiology/Respiratory Physiology; Polymerization; Proteïnes citosquelètiques; Public health; Regulació cel·lular; Reinforcement; Rheology; Science; Smooth muscle; Softness; Stress, Mechanical; Traction; Urinary bladder; United States > US; Massachusetts

Every adherent eukaryotic cell exerts appreciable traction forces upon its substrate. Moreover, every resident cell within the heart, great vessels, bladder, gut or lung routinely experiences large periodic stretches. As an acute response to such stretches the cytoskeleton can stiffen, increase trac...