AMP-Activated Protein Kinase Directly Phosphorylates and Destabilizes Hedgehog Pathway Transcription Factor GLI1 in Medulloblastoma

• Published in: Cell reports (Cambridge) Vol. 12; no. 4; pp. 599 - 609
• Main Authors: Li, Yen-Hsing, Luo, Jia, Mosley, Yung-Yi C., Hedrick, Victoria E., Paul, Lake N., Chang, Julia, Zhang, GuangJun, Wang, Yu-Kuo, Banko, Max R., Brunet, Anne, Kuang, Shihuan, Wu, Jen-Leih, Chang, Chun-Ju, Scott, Matthew P., Yang, Jer-Yen
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 28.07.2015; Elsevier
• Subjects: 3T3 Cells; Amino Acid Sequence; AMP-Activated Protein Kinases - metabolism; Animals; Cell Line, Tumor; HEK293 Cells; Humans; Medulloblastoma - metabolism; Mice; Molecular Sequence Data; Phosphorylation; Protein Processing, Post-Translational; Protein Stability; Transcription Factors - chemistry; Transcription Factors - metabolism; Zebrafish; Zinc Finger Protein GLI1

The Hedgehog (Hh) pathway regulates cell differentiation and proliferation during development by controlling the Gli transcription factors. Cell fate decisions and progression toward organ and tissue maturity must be coordinated, and how an energy sensor regulates the Hh pathway is not clear. AMP-ac...