Branched-chain amino acids in health and disease: metabolism, alterations in blood plasma, and as supplements

• Published in: Nutrition & metabolism Vol. 15; no. 1; p. 33
• Main Author: Holecek, Milan
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 03.05.2018; BioMed Central; BMC
• Subjects: adverse effects; alanine; amination; Ammonia; Blood plasma; Branched chain amino acids; Cachexia; Cirrhosis; Diabetes; essential amino acids; exercise; Glutamine; Health aspects; insulin-dependent diabetes mellitus; isoleucine; keto acids; leucine; liver cirrhosis; maple syrup urine disease; metabolism; muscles; neoplasms; Nutrition; obesity; oxidation; patients; renal failure; Review; sepsis (infection); skeletal muscle; starvation; therapeutics; urea cycle disorders; valine; Ammonia; Cirrhosis; Cachexia; Diabetes; Nutrition; Glutamine

Branched-chain amino acids (BCAAs; valine, leucine, and isoleucine) are essential amino acids with protein anabolic properties, which have been studied in a number of muscle wasting disorders for more than 50 years. However, until today, there is no consensus regarding their therapeutic effectivenes...