Identification of ACSL4 as a biomarker and contributor of ferroptosis

• Published in: Biochemical and biophysical research communications Vol. 478; no. 3; pp. 1338 - 1343
• Main Authors: Yuan, Hua, Li, Xuemei, Zhang, Xiuying, Kang, Rui, Tang, Daolin
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 23.09.2016
• Subjects: ACSL; Apoptosis - drug effects; Biomarker; biomarkers; Biomarkers, Tumor - metabolism; cell death; Cell Line, Tumor; Coenzyme A Ligases - metabolism; Ferroptosis; Gene Knockdown Techniques; gene overexpression; genes; Humans; Hydroxyeicosatetraenoic acid; Hydroxyeicosatetraenoic Acids - biosynthesis; Lipid metabolism; lipid peroxidation; long-chain-fatty-acid-CoA ligase; neoplasms; Piperazines - pharmacology; transfection; AA; Biomarker; ACSL; CISD1; Q-PCR; Ferroptosis; MDA; COX; HETE; Fe2; LOX; Hydroxyeicosatetraenoic acid; CCK-8; Lipid metabolism

Ferroptosis, a recently identified form of non-apoptotic cell death, is involved in several physiological and pathological processes. Although lipid peroxidation plays a central role in triggering ferroptosis, the essential regulator of lipid metabolism in ferroptosis remains poorly defined. Here, w...