Differential control of muscle mass in type 1 and type 2 diabetes mellitus

• Published in: Cellular and molecular life sciences : CMLS Vol. 72; no. 20; pp. 3803 - 3817
• Main Authors: Sala, David, Zorzano, Antonio
• Format: Journal Article
• Language: English
• Published: Basel Springer Basel 01.10.2015; Springer Nature B.V
• Subjects: Amino acids; Animal models; Animals; Atrophy; Autophagy; Biochemistry; Biomedical and Life Sciences; Biomedicine; Cell Biology; Diabetes; Diabetes Complications - metabolism; Diabetes Complications - pathology; Diabetes mellitus; Diabetes mellitus (insulin dependent); Diabetes mellitus (non-insulin dependent); Diabetes Mellitus - metabolism; Diabetes Mellitus - pathology; Disease Models, Animal; glucose; Glucose metabolism; Humans; Insulin; Insulin - metabolism; Insulin resistance; insulin-dependent diabetes mellitus; Life Sciences; Lipid metabolism; Lipids; metabolism; Mice; Models, Biological; Muscles; muscular atrophy; Muscular Atrophy - complications; Muscular Atrophy - metabolism; Muscular system; noninsulin-dependent diabetes mellitus; Proteases; Proteins - metabolism; Rats; Regulatory mechanisms (biology); Review; Muscle atrophy; Proteostasis; Autophagy; TP53INP2; Proteasome

Diabetes mellitus—whether driven by insulin deficiency or insulin resistance—causes major alterations in muscle metabolism. These alterations have an impact on nutrient handling, including the metabolism of glucose, lipids, and amino acids, and also on muscle mass and strength. However, the ways in...