Time-dependent effect of 1,6-hexanediol on biomolecular condensates and 3D chromatin organization

• Published in: Genome Biology Vol. 22; no. 1; p. 230
• Main Authors: Liu, Xinyi, Jiang, Shaoshuai, Ma, Lin, Qu, Jiale, Zhao, Longying, Zhu, Xing, Ding, Junjun
• Format: Journal Article
• Language: English
• Published: England BioMed Central 17.08.2021; BMC
• Subjects: 1,6-Hexanediol; 3D chromatin organization; acute exposure; Apoptosis; Biomolecular condensates; Biomolecular Condensates - chemistry; Biomolecular Condensates - drug effects; Cell Physiological Phenomena; Cell viability; Chromatin; chronic exposure; Condensates; Gene loci; genome; Glycols - chemistry; Glycols - pharmacology; HeLa Cells; Humans; Imaging, Three-Dimensional; Phase transitions; Proteins; RNA polymerase; Stem cells; 1,6-Hexanediol; Biomolecular condensates; 3D chromatin organization

Biomolecular condensates have been implicated in multiple cellular processes. However, the global role played by condensates in 3D chromatin organization remains unclear. At present, 1,6-hexanediol (1,6-HD) is the only available tool to globally disrupt condensates, yet the conditions of 1,6-HD vary...