TAD-like single-cell domain structures exist on both active and inactive X chromosomes and persist under epigenetic perturbations

• Published in: Genome Biology Vol. 22; no. 1; p. 309
• Main Authors: Cheng, Yubao, Liu, Miao, Hu, Mengwei, Wang, Siyuan
• Format: Journal Article
• Language: English
• Published: England BioMed Central 08.11.2021; BMC
• Subjects: Binding sites; Cell lines; Chromatin; Chromatin - chemistry; Chromatin folding; Chromosomes, Human, X - chemistry; Cohesin; Computer applications; domain; Epigenesis, Genetic; Epigenetics; Female; females; genome; Genomes; Genomics; Humans; Hybridization; Population; Probability; Single-cell domain; TAD-like structure; Topologically associating domain (TAD); Transcription; Transcription, Genetic; X chromosome; X chromosomes; X inactivation; Chromatin folding; Single-cell domain; Image-based spatial genomics; Multiplexed sequential fluorescence in situ hybridization (FISH); TAD-like structure; Chromatin compaction; X chromosome; 3D genomics; X inactivation; Topologically associating domain (TAD); Chromatin tracing

Topologically associating domains (TADs) are important building blocks of three-dimensional genome architectures. The formation of TADs has been shown to depend on cohesin in a loop-extrusion mechanism. Recently, advances in an image-based spatial genomics technique known as chromatin tracing lead t...