Large-scale mutagenesis of the mouse to understand the genetic bases of nervous system structure and function

N-ethyl- N-nitrosourea (ENU) mutagenesis is presented as a powerful approach to developing models for human disease. The efforts of three NIH Mutagenesis Centers established for the detection of neuroscience-related phenotypes are described. Each center has developed an extensive panel of phenotype...

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Published in	Brain research. Molecular brain research. Vol. 132; no. 2; pp. 105 - 115
Main Authors	Goldowitz, Dan, Frankel, Wayne N., Takahashi, Joseph S., Holtz-Vitaterna, Martha, Bult, Carol, Kibbe, Warren A., Snoddy, Jay, Li, Yanxia, Pretel, Stephanie, Yates, Jeana, Swanson, Douglas J.
Format	Journal Article Conference Proceeding
Language	English
Published	Amsterdam Elsevier B.V 20.12.2004 Elsevier
Subjects	Alkylating Agents Animals Biological and medical sciences Ethylnitrosourea Functional genomics Fundamental and applied biological sciences. Psychology Mice Mouse mutants behavioral phenotype Mutagenesis N-ethyl- N-nitrosourea (ENU) Nervous System Diseases - genetics Nervous System Physiological Phenomena Neurogenetics Vertebrates: nervous system and sense organs N-ethyl- N-nitrosourea (ENU) Mouse mutants behavioral phenotype Neurogenetics Neural basis of behavior Functional genomics Vertebrata Mammalia N-ethyl-N-nitrosourea (ENU) Mouse Animal Rodentia Nervous system Behavior Mutation
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ISSN	0169-328X 1872-6941
DOI	10.1016/j.molbrainres.2004.09.016

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Abstract	N-ethyl- N-nitrosourea (ENU) mutagenesis is presented as a powerful approach to developing models for human disease. The efforts of three NIH Mutagenesis Centers established for the detection of neuroscience-related phenotypes are described. Each center has developed an extensive panel of phenotype screens that assess nervous system structure and function. In particular, these screens focus on complex behavioral traits from drug and alcohol responses to circadian rhythms to epilepsy. Each of these centers has developed a bioinformatics infrastructure to track the extensive number of transactions that are inherent in these large-scale projects. Over 100 new mouse mutant lines have been defined through the efforts of these three mutagenesis centers and are presented to the research community via the centralized Web presence of the Neuromice.org consortium ( http://www.neuromice.org). This community resource provides visitors with the ability to search for specific mutant phenotypes, to view the genetic and phenotypic details of mutant mouse lines, and to order these mice for use in their own research program.
AbstractList	N-ethyl-N-nitrosourea (ENU) mutagenesis is presented as a powerful approach to developing models for human disease. The efforts of three NIH Mutagenesis Centers established for the detection of neuroscience-related phenotypes are described. Each center has developed an extensive panel of phenotype screens that assess nervous system structure and function. In particular, these screens focus on complex behavioral traits from drug and alcohol responses to circadian rhythms to epilepsy. Each of these centers has developed a bioinformatics infrastructure to track the extensive number of transactions that are inherent in these large-scale projects. Over 100 new mouse mutant lines have been defined through the efforts of these three mutagenesis centers and are presented to the research community via the centralized Web presence of the Neuromice.org consortium ( http://www.neuromice.org ). This community resource provides visitors with the ability to search for specific mutant phenotypes, to view the genetic and phenotypic details of mutant mouse lines, and to order these mice for use in their own research program. N-ethyl-N-nitrosourea (ENU) mutagenesis is presented as a powerful approach to developing models for human disease. The efforts of three NIH Mutagenesis Centers established for the detection of neuroscience-related phenotypes are described. Each center has developed an extensive panel of phenotype screens that assess nervous system structure and function. In particular, these screens focus on complex behavioral traits from drug and alcohol responses to circadian rhythms to epilepsy. Each of these centers has developed a bioinformatics infrastructure to track the extensive number of transactions that are inherent in these large-scale projects. Over 100 new mouse mutant lines have been defined through the efforts of these three mutagenesis centers and are presented to the research community via the centralized Web presence of the Neuromice.org consortium (http://www.neuromice.org). This community resource provides visitors with the ability to search for specific mutant phenotypes, to view the genetic and phenotypic details of mutant mouse lines, and to order these mice for use in their own research program.N-ethyl-N-nitrosourea (ENU) mutagenesis is presented as a powerful approach to developing models for human disease. The efforts of three NIH Mutagenesis Centers established for the detection of neuroscience-related phenotypes are described. Each center has developed an extensive panel of phenotype screens that assess nervous system structure and function. In particular, these screens focus on complex behavioral traits from drug and alcohol responses to circadian rhythms to epilepsy. Each of these centers has developed a bioinformatics infrastructure to track the extensive number of transactions that are inherent in these large-scale projects. Over 100 new mouse mutant lines have been defined through the efforts of these three mutagenesis centers and are presented to the research community via the centralized Web presence of the Neuromice.org consortium (http://www.neuromice.org). This community resource provides visitors with the ability to search for specific mutant phenotypes, to view the genetic and phenotypic details of mutant mouse lines, and to order these mice for use in their own research program. N-ethyl- N-nitrosourea (ENU) mutagenesis is presented as a powerful approach to developing models for human disease. The efforts of three NIH Mutagenesis Centers established for the detection of neuroscience-related phenotypes are described. Each center has developed an extensive panel of phenotype screens that assess nervous system structure and function. In particular, these screens focus on complex behavioral traits from drug and alcohol responses to circadian rhythms to epilepsy. Each of these centers has developed a bioinformatics infrastructure to track the extensive number of transactions that are inherent in these large-scale projects. Over 100 new mouse mutant lines have been defined through the efforts of these three mutagenesis centers and are presented to the research community via the centralized Web presence of the Neuromice.org consortium ( http://www.neuromice.org). This community resource provides visitors with the ability to search for specific mutant phenotypes, to view the genetic and phenotypic details of mutant mouse lines, and to order these mice for use in their own research program. N-ethyl-N-nitrosourea (ENU) mutagenesis is presented as a powerful approach to developing models for human disease. The efforts of three NIH Mutagenesis Centers established for the detection of neuroscience-related phenotypes are described. Each center has developed an extensive panel of phenotype screens that assess nervous system structure and function. In particular, these screens focus on complex behavioral traits from drug and alcohol responses to circadian rhythms to epilepsy. Each of these centers has developed a bioinformatics infrastructure to track the extensive number of transactions that are inherent in these large-scale projects. Over 100 new mouse mutant lines have been defined through the efforts of these three mutagenesis centers and are presented to the research community via the centralized Web presence of the Neuromice.org consortium (http://www.neuromice.org). This community resource provides visitors with the ability to search for specific mutant phenotypes, to view the genetic and phenotypic details of mutant mouse lines, and to order these mice for use in their own research program.
Author	Snoddy, Jay Frankel, Wayne N. Takahashi, Joseph S. Holtz-Vitaterna, Martha Pretel, Stephanie Swanson, Douglas J. Bult, Carol Yates, Jeana Goldowitz, Dan Kibbe, Warren A. Li, Yanxia
AuthorAffiliation	d Oak Ridge National Laboratory, United States b The Jackson Laboratory, United States c Northwestern University, United States a Dept. Anatomy and Neurobiology, University of Tennessee Health Science Center, 855 Monroe Ave., Memphis, TN 38163, United States
AuthorAffiliation_xml	– name: c Northwestern University, United States – name: d Oak Ridge National Laboratory, United States – name: b The Jackson Laboratory, United States – name: a Dept. Anatomy and Neurobiology, University of Tennessee Health Science Center, 855 Monroe Ave., Memphis, TN 38163, United States
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Keywords	N-ethyl- N-nitrosourea (ENU) Mouse mutants behavioral phenotype Neurogenetics Neural basis of behavior Functional genomics Vertebrata Mammalia N-ethyl-N-nitrosourea (ENU) Mouse Animal Rodentia Nervous system Behavior Mutation
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Snippet	N-ethyl- N-nitrosourea (ENU) mutagenesis is presented as a powerful approach to developing models for human disease. The efforts of three NIH Mutagenesis... N-ethyl-N-nitrosourea (ENU) mutagenesis is presented as a powerful approach to developing models for human disease. The efforts of three NIH Mutagenesis...
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SubjectTerms	Alkylating Agents Animals Biological and medical sciences Ethylnitrosourea Functional genomics Fundamental and applied biological sciences. Psychology Mice Mouse mutants behavioral phenotype Mutagenesis N-ethyl- N-nitrosourea (ENU) Nervous System Diseases - genetics Nervous System Physiological Phenomena Neurogenetics Vertebrates: nervous system and sense organs
Title	Large-scale mutagenesis of the mouse to understand the genetic bases of nervous system structure and function
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