Characterization of accessory genes in coronavirus genomes

• Published in: Virology journal Vol. 17; no. 1; p. 131
• Main Authors: Michel, Christian Jean, Mayer, Claudine, Poch, Olivier, Thompson, Julie Dawn
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 27.08.2020; BioMed Central; BMC
• Subjects: Accessory genes; Analysis; Animals; Betacoronavirus - genetics; Biochemistry, Molecular Biology; Bioinformatics; Chiroptera; Codon; Computational Biology; Computer applications; Coronaviridae; Coronavirus; Coronaviruses; COVID-19; COVID-19 infection; drugs; Evolution, Molecular; Genes; Genes, Viral; Genetic research; Genome, Viral; Genomes; Genomics; Health aspects; hosts; Humans; Infection; Life Sciences; Middle East respiratory syndrome; Open Reading Frames; ORF prediction; pathogenesis; Pholidota (mammals); polyproteins; Proteins; SARS-CoV; SARS-CoV-2; Severe acute respiratory syndrome coronavirus 2; Severe acute respiratory syndrome-related coronavirus; Severe acute respiratory syndrome-related coronavirus - genetics; Spike Glycoprotein, Coronavirus - chemistry; Spike Glycoprotein, Coronavirus - genetics; Spike protein; Structural proteins; Therapeutic targets; Viral Matrix Proteins - genetics; Viral Proteins - chemistry; Viral Proteins - genetics; Viral Regulatory and Accessory Proteins - chemistry; Viral Regulatory and Accessory Proteins - genetics; virus replication; Viruses; Viverridae; COVID-19; Accessory genes; SARS-CoV-2; Coronavirus; ORF prediction; SARS-CoV; Circular code motifs

The Covid19 infection is caused by the SARS-CoV-2 virus, a novel member of the coronavirus (CoV) family. CoV genomes code for a ORF1a / ORF1ab polyprotein and four structural proteins widely studied as major drug targets. The genomes also contain a variable number of open reading frames (ORFs) codin...