Integration of metabolomics, genomics, and immune phenotypes reveals the causal roles of metabolites in disease

Recent studies highlight the role of metabolites in immune diseases, but it remains unknown how much of this effect is driven by genetic and non-genetic host factors. We systematically investigate circulating metabolites in a cohort of 500 healthy subjects (500FG) in whom immune function and activit...

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Published inGenome Biology Vol. 22; no. 1; p. 198
Main Authors Chu, Xiaojing, Jaeger, Martin, Beumer, Joep, Bakker, Olivier B., Aguirre-Gamboa, Raul, Oosting, Marije, Smeekens, Sanne P., Moorlag, Simone, Mourits, Vera P., Koeken, Valerie A. C. M., de Bree, Charlotte, Jansen, Trees, Mathews, Ian T., Dao, Khoi, Najhawan, Mahan, Watrous, Jeramie D., Joosten, Irma, Sharma, Sonia, Koenen, Hans J. P. M., Withoff, Sebo, Jonkers, Iris H., Netea-Maier, Romana T., Xavier, Ramnik J., Franke, Lude, Xu, Cheng-Jian, Joosten, Leo A. B., Sanna, Serena, Jain, Mohit, Kumar, Vinod, Clevers, Hans, Wijmenga, Cisca, Netea, Mihai G., Li, Yang
Format Journal Article
LanguageEnglish
Published England BioMed Central 06.07.2021
BMC
Subjects
Adolescent
Adult
Age
Aged
Alanine
Alanine - blood
Alanine - immunology
Arachidonic acid
Arachidonic Acid - blood
Arachidonic Acid - immunology
Association analysis
blood
Body mass index
Chromatography
Cohort Studies
Correlation analysis
Crohn's disease
Cytokines
Disease
Female
Gender
Genetic factors
genome
Genome-Wide Association Study
Genomics
Genomics - methods
glutamic acid
Glutamic Acid - blood
Glutamic Acid - immunology
Healthy Volunteers
Humans
Immune phenotypes
Immune response
Immune system
Immunity, Innate - genetics
Immunoglobulins
Immunological diseases
Integration
Integrative analysis
loci
Male
Mass spectrometry
Metabolic Networks and Pathways - genetics
Metabolic Networks and Pathways - immunology
Metabolic pathways
Metabolism
Metabolites
metabolome
Metabolomics
Metabolomics - methods
Middle Aged
NMR
Nuclear magnetic resonance
Phenotype
Phenotypes
Quantitative Trait Loci
Roles
Scientific imaging
Therapeutic targets
therapeutics
Integrative analysis
Metabolomics
Genomics
Immune phenotypes
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Abstract Recent studies highlight the role of metabolites in immune diseases, but it remains unknown how much of this effect is driven by genetic and non-genetic host factors. We systematically investigate circulating metabolites in a cohort of 500 healthy subjects (500FG) in whom immune function and activity are deeply measured and whose genetics are profiled. Our data reveal that several major metabolic pathways, including the alanine/glutamate pathway and the arachidonic acid pathway, have a strong impact on cytokine production in response to ex vivo stimulation. We also examine the genetic regulation of metabolites associated with immune phenotypes through genome-wide association analysis and identify 29 significant loci, including eight novel independent loci. Of these, one locus (rs174584-FADS2) associated with arachidonic acid metabolism is causally associated with Crohn's disease, suggesting it is a potential therapeutic target. This study provides a comprehensive map of the integration between the blood metabolome and immune phenotypes, reveals novel genetic factors that regulate blood metabolite concentrations, and proposes an integrative approach for identifying new disease treatment targets.
AbstractList BACKGROUND: Recent studies highlight the role of metabolites in immune diseases, but it remains unknown how much of this effect is driven by genetic and non-genetic host factors. RESULT: We systematically investigate circulating metabolites in a cohort of 500 healthy subjects (500FG) in whom immune function and activity are deeply measured and whose genetics are profiled. Our data reveal that several major metabolic pathways, including the alanine/glutamate pathway and the arachidonic acid pathway, have a strong impact on cytokine production in response to ex vivo stimulation. We also examine the genetic regulation of metabolites associated with immune phenotypes through genome-wide association analysis and identify 29 significant loci, including eight novel independent loci. Of these, one locus (rs174584-FADS2) associated with arachidonic acid metabolism is causally associated with Crohn’s disease, suggesting it is a potential therapeutic target. CONCLUSION: This study provides a comprehensive map of the integration between the blood metabolome and immune phenotypes, reveals novel genetic factors that regulate blood metabolite concentrations, and proposes an integrative approach for identifying new disease treatment targets.
Abstract Background Recent studies highlight the role of metabolites in immune diseases, but it remains unknown how much of this effect is driven by genetic and non-genetic host factors. Result We systematically investigate circulating metabolites in a cohort of 500 healthy subjects (500FG) in whom immune function and activity are deeply measured and whose genetics are profiled. Our data reveal that several major metabolic pathways, including the alanine/glutamate pathway and the arachidonic acid pathway, have a strong impact on cytokine production in response to ex vivo stimulation. We also examine the genetic regulation of metabolites associated with immune phenotypes through genome-wide association analysis and identify 29 significant loci, including eight novel independent loci. Of these, one locus (rs174584-FADS2) associated with arachidonic acid metabolism is causally associated with Crohn’s disease, suggesting it is a potential therapeutic target. Conclusion This study provides a comprehensive map of the integration between the blood metabolome and immune phenotypes, reveals novel genetic factors that regulate blood metabolite concentrations, and proposes an integrative approach for identifying new disease treatment targets.
Recent studies highlight the role of metabolites in immune diseases, but it remains unknown how much of this effect is driven by genetic and non-genetic host factors.BACKGROUNDRecent studies highlight the role of metabolites in immune diseases, but it remains unknown how much of this effect is driven by genetic and non-genetic host factors.We systematically investigate circulating metabolites in a cohort of 500 healthy subjects (500FG) in whom immune function and activity are deeply measured and whose genetics are profiled. Our data reveal that several major metabolic pathways, including the alanine/glutamate pathway and the arachidonic acid pathway, have a strong impact on cytokine production in response to ex vivo stimulation. We also examine the genetic regulation of metabolites associated with immune phenotypes through genome-wide association analysis and identify 29 significant loci, including eight novel independent loci. Of these, one locus (rs174584-FADS2) associated with arachidonic acid metabolism is causally associated with Crohn's disease, suggesting it is a potential therapeutic target.RESULTWe systematically investigate circulating metabolites in a cohort of 500 healthy subjects (500FG) in whom immune function and activity are deeply measured and whose genetics are profiled. Our data reveal that several major metabolic pathways, including the alanine/glutamate pathway and the arachidonic acid pathway, have a strong impact on cytokine production in response to ex vivo stimulation. We also examine the genetic regulation of metabolites associated with immune phenotypes through genome-wide association analysis and identify 29 significant loci, including eight novel independent loci. Of these, one locus (rs174584-FADS2) associated with arachidonic acid metabolism is causally associated with Crohn's disease, suggesting it is a potential therapeutic target.This study provides a comprehensive map of the integration between the blood metabolome and immune phenotypes, reveals novel genetic factors that regulate blood metabolite concentrations, and proposes an integrative approach for identifying new disease treatment targets.CONCLUSIONThis study provides a comprehensive map of the integration between the blood metabolome and immune phenotypes, reveals novel genetic factors that regulate blood metabolite concentrations, and proposes an integrative approach for identifying new disease treatment targets.
Recent studies highlight the role of metabolites in immune diseases, but it remains unknown how much of this effect is driven by genetic and non-genetic host factors. We systematically investigate circulating metabolites in a cohort of 500 healthy subjects (500FG) in whom immune function and activity are deeply measured and whose genetics are profiled. Our data reveal that several major metabolic pathways, including the alanine/glutamate pathway and the arachidonic acid pathway, have a strong impact on cytokine production in response to ex vivo stimulation. We also examine the genetic regulation of metabolites associated with immune phenotypes through genome-wide association analysis and identify 29 significant loci, including eight novel independent loci. Of these, one locus (rs174584-FADS2) associated with arachidonic acid metabolism is causally associated with Crohn's disease, suggesting it is a potential therapeutic target. This study provides a comprehensive map of the integration between the blood metabolome and immune phenotypes, reveals novel genetic factors that regulate blood metabolite concentrations, and proposes an integrative approach for identifying new disease treatment targets.
ArticleNumber 198
Author Wijmenga, Cisca
Jain, Mohit
Mourits, Vera P.
Clevers, Hans
Smeekens, Sanne P.
Franke, Lude
Withoff, Sebo
Koeken, Valerie A. C. M.
Joosten, Irma
de Bree, Charlotte
Watrous, Jeramie D.
Jaeger, Martin
Aguirre-Gamboa, Raul
Sanna, Serena
Bakker, Olivier B.
Moorlag, Simone
Mathews, Ian T.
Netea-Maier, Romana T.
Xu, Cheng-Jian
Najhawan, Mahan
Jonkers, Iris H.
Joosten, Leo A. B.
Chu, Xiaojing
Jansen, Trees
Kumar, Vinod
Netea, Mihai G.
Dao, Khoi
Koenen, Hans J. P. M.
Xavier, Ramnik J.
Sharma, Sonia
Oosting, Marije
Li, Yang
Beumer, Joep
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/34229738$$D View this record in MEDLINE/PubMed
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IsDoiOpenAccess true
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Issue 1
Keywords Integrative analysis
Metabolomics
Genomics
Immune phenotypes
Language English
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Snippet Recent studies highlight the role of metabolites in immune diseases, but it remains unknown how much of this effect is driven by genetic and non-genetic host...
Background Recent studies highlight the role of metabolites in immune diseases, but it remains unknown how much of this effect is driven by genetic and...
BACKGROUND: Recent studies highlight the role of metabolites in immune diseases, but it remains unknown how much of this effect is driven by genetic and...
Abstract Background Recent studies highlight the role of metabolites in immune diseases, but it remains unknown how much of this effect is driven by genetic...
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SubjectTerms Adolescent
Adult
Age
Aged
Alanine
Alanine - blood
Alanine - immunology
Arachidonic acid
Arachidonic Acid - blood
Arachidonic Acid - immunology
Association analysis
blood
Body mass index
Chromatography
Cohort Studies
Correlation analysis
Crohn's disease
Cytokines
Disease
Female
Gender
Genetic factors
genome
Genome-Wide Association Study
Genomics
Genomics - methods
glutamic acid
Glutamic Acid - blood
Glutamic Acid - immunology
Healthy Volunteers
Humans
Immune phenotypes
Immune response
Immune system
Immunity, Innate - genetics
Immunoglobulins
Immunological diseases
Integration
Integrative analysis
loci
Male
Mass spectrometry
Metabolic Networks and Pathways - genetics
Metabolic Networks and Pathways - immunology
Metabolic pathways
Metabolism
Metabolites
metabolome
Metabolomics
Metabolomics - methods
Middle Aged
NMR
Nuclear magnetic resonance
Phenotype
Phenotypes
Quantitative Trait Loci
Roles
Scientific imaging
Therapeutic targets
therapeutics
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Title Integration of metabolomics, genomics, and immune phenotypes reveals the causal roles of metabolites in disease
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https://www.proquest.com/docview/2553256414
https://www.proquest.com/docview/2549209255
https://www.proquest.com/docview/2661004726
https://pubmed.ncbi.nlm.nih.gov/PMC8259168
https://doaj.org/article/c356b25dd4854dcbb5ff8d2fda446129
Volume 22
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